Wanjun Yu
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View article: CircFOXK2 induces non-small cell lung cancer tumorigenesis through the miR-328-5p/PKP3 axis
CircFOXK2 induces non-small cell lung cancer tumorigenesis through the miR-328-5p/PKP3 axis Open
Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) implicated in the onset and advancement of various human cancers. Among these, circFOXK2 has been linked to non-small cell lung cancer (NSCLC); however, its precise functions and underl…
View article: Association between anti-nuclear antibody (ANA) positivity and autoimmune thyroid disease markers in a general examination population
Association between anti-nuclear antibody (ANA) positivity and autoimmune thyroid disease markers in a general examination population Open
Elevated thyroid autoantibodies (TPOAb, TgAb) are strongly associated with increased ANA positivity risk, suggesting a link between thyroid-specific and systemic autoimmunity. Thyroid hormone levels showed minimal association. Patients wit…
View article: Managing severe dermatitis and grade 4 pneumonitis in a patient with non‑small‑cell lung cancer following pembrolizumab treatment: A case report
Managing severe dermatitis and grade 4 pneumonitis in a patient with non‑small‑cell lung cancer following pembrolizumab treatment: A case report Open
Inhibitors of the programmed death receptor 1 (PD-1) or its ligand PD-L1 are widely used in cancer treatment. Despite their efficacy, these immunotherapies can induce adverse effects, particularly dermatitis and pneumonitis. However, the p…
View article: Combined Systemic Immune-Inflammation Index-Prognostic Nutritional Index Score in Evaluating the Prognosis of Patients with Severe Community-Acquired Pneumonia
Combined Systemic Immune-Inflammation Index-Prognostic Nutritional Index Score in Evaluating the Prognosis of Patients with Severe Community-Acquired Pneumonia Open
Our results indicate that a higher SII-PNI score at admission was linked to poor prognosis in SCAP patients. The combined SII-PNI score can effectively help clinicians assess disease progression and optimize risk assessment and clinical ma…
View article: Safety and efficacy of inhalable ambroxol hydrochloride aerosol for adult patients with respiratory diseases: an open-label, single-arm, multicentre study
Safety and efficacy of inhalable ambroxol hydrochloride aerosol for adult patients with respiratory diseases: an open-label, single-arm, multicentre study Open
Background Airway mucus hypersecretion is a key pathophysiological feature in many respiratory diseases and could lead to airway obstruction and repeated infections, consequently accelerating disease progression, which impacts on pulmonary…
View article: Corynoxine suppresses lung adenocarcinoma proliferation and metastasis via inhibiting PI3K/AKT pathway and suppressing Cyclooxygenase-2 expression
Corynoxine suppresses lung adenocarcinoma proliferation and metastasis via inhibiting PI3K/AKT pathway and suppressing Cyclooxygenase-2 expression Open
Background Lung adenocarcinoma (LUAD) is the most common lung cancer subtype, and the prognosis of affected patients is generally poor. The traditional Chinese medicine Uncaria rhychophaylla has been reported to exhibit anti-lung cancer pr…
View article: Corrigendum: Exosomal CD44 transmits lymph node metastatic capacity between gastric cancer cells via YAP-CPT1A-mediated FAO reprogramming
Corrigendum: Exosomal CD44 transmits lymph node metastatic capacity between gastric cancer cells via YAP-CPT1A-mediated FAO reprogramming Open
[This corrects the article DOI: 10.3389/fonc.2022.860175.].
View article: Circular RNA circEZH2 Promotes Lung Adenocarcinoma Progression by Regulating microRNA-495-3p/Tumor Protein D52 Axis and Activating Nuclear Factor-Kappa B Pathway
Circular RNA circEZH2 Promotes Lung Adenocarcinoma Progression by Regulating microRNA-495-3p/Tumor Protein D52 Axis and Activating Nuclear Factor-Kappa B Pathway Open
These findings indicate that circEZH2 may function as a competitive endogenous RNA (ceRNA), driving the progression of LUAD by manipulating the miR-495-3p/TPD52 axis and activating the NF-κB pathway.
View article: SARS‑CoV‑2 infection exacerbates diaphragmatic eventration: A case report
SARS‑CoV‑2 infection exacerbates diaphragmatic eventration: A case report Open
Adult congenital localized diaphragmatic eventration (DE) is an uncommon condition that, due to the absence of notable symptoms, is often ignored and is consequently not frequently treated following diagnosis. Furthermore, the progression …
View article: DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma Open
View article: Interleukin-17A Promotes Airway Remodeling in Chronic Obstructive Pulmonary Disease by Activating C-X-C Motif Chemokine Ligand 12 Secreted by Lung Fibroblasts
Interleukin-17A Promotes Airway Remodeling in Chronic Obstructive Pulmonary Disease by Activating C-X-C Motif Chemokine Ligand 12 Secreted by Lung Fibroblasts Open
This study showed that exposure of mice to CS and IL-17A stimulation upregulated CXCL12 expression and induced EMT by activating the ERK signaling pathway. These data offer a novel perspective regarding the molecular mechanism of CXCL12/CX…
View article: Additional file 1 of DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
Additional file 1 of DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma Open
Supplementary Material 1: Supplementary Table S1 Materials
View article: Preparation and in Vitro Property Research of Cholic Acid Nanoparticles with Dual Functions of Hemostasis and Antibacterial
Preparation and in Vitro Property Research of Cholic Acid Nanoparticles with Dual Functions of Hemostasis and Antibacterial Open
Background: Hemorrhage control and anti-infection play a crucial role in promoting wound healing in trauma-related injuries. Objectives: This study aimed to prepare nanoparticles with dual functions of hemostasis and antibacterial properti…
View article: The survival benefit from surgery on patients with large-cell neuroendocrine carcinoma in the lung: a propensity-score matching study
The survival benefit from surgery on patients with large-cell neuroendocrine carcinoma in the lung: a propensity-score matching study Open
Purpose This study aimed to investigate the prognostic significance of surgery in large-cell neuroendocrine carcinoma (LCNC) patients. Methods A total of 453 patients from the Surveillance, Epidemiology, and End Results database diagnosed …
View article: Reconsidering N component of cancer staging for T1-2N0-2M0 small-cell lung cancer: a retrospective study based on multicenter cohort
Reconsidering N component of cancer staging for T1-2N0-2M0 small-cell lung cancer: a retrospective study based on multicenter cohort Open
Background The current nodal (pN) classification still has limitations in stratifying the prognosis of small cell lung cancer (SCLC) patients with pathological classifications T1-2N0-2M0. Thus. This study aimed to develop and validate a mo…
View article: NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma Open
Background Lung cancer is the leading cause of cancer-related deaths worldwide, and despite recent advances in targeted therapies and immunotherapies, the clinical benefit remains limited. Therefore, there is an urgent need to further inve…
View article: A multidimensional pan‐cancer analysis of <scp>DCAF13</scp> and its protumorigenic effect in lung adenocarcinoma
A multidimensional pan‐cancer analysis of <span>DCAF13</span> and its protumorigenic effect in lung adenocarcinoma Open
DCAF13 is a substrate recognition protein in the ubiquitin‐proteasome system with oncogenic effects in several malignant tumors. However, it is unclear that the relationship between DCAF13 expression pattern and prognosis across different …
View article: Additional file 5 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
Additional file 5 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma Open
Additional file 5: Supplementary Table S2. A protein-protein interactionnetwork parameter based on NPM3.
View article: Additional file 7 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
Additional file 7 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma Open
Additional file 7: Supplementary Table S4. The KEGG enrichment pathway of genes positivelyassociated with NPM3 expression.
View article: Additional file 8 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
Additional file 8 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma Open
Additional file 8: Supplementary Table S5. The genes negatively associated with NPM3 expression.
View article: The postoperative prognosis of skip-N2 metastasis is favorable in small-cell lung carcinoma patients with pathological N2 classification: a propensity-score-adjusted retrospective multicenter study
The postoperative prognosis of skip-N2 metastasis is favorable in small-cell lung carcinoma patients with pathological N2 classification: a propensity-score-adjusted retrospective multicenter study Open
Background: The study on skip-N2 metastasis in small-cell lung cancer (SCLC) is lacking. Therefore, this study aimed to explore the prognostic significance of skip-N2 metastasis based on a multicenter cohort. Methods: We collected 176 SCLC…
View article: Additional file 4 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
Additional file 4 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma Open
Additional file 4: Supplementary Table S1. Primer sequences.
View article: Additional file 6 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
Additional file 6 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma Open
Additional file 6: Supplementary Table S3. The genes positively associated with NPM3 expression.
View article: Additional file 9 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
Additional file 9 of NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma Open
Additional file 9: Supplementary Table S6. The KEGG enrichment pathway of genes negativelyassociated with NPM3 expression.
View article: Serum transfer <scp>RNA</scp>‐derived fragment <scp>tRF‐31‐79MP9P9NH57SD</scp> acts as a novel diagnostic biomarker for non‐small cell lung cancer
Serum transfer <span>RNA</span>‐derived fragment <span>tRF‐31‐79MP9P9NH57SD</span> acts as a novel diagnostic biomarker for non‐small cell lung cancer Open
Background tRNA‐derived fragments (tRFs) have been found to have a crucial function in the pathophysiology of cancers. However, the function of tRFs in non‐small cell lung cancer (NSCLC) is yet unknown. The goal of this study was to assess…
View article: Exosomal CD44 Transmits Lymph Node Metastatic Capacity Between Gastric Cancer Cells via YAP-CPT1A-Mediated FAO Reprogramming
Exosomal CD44 Transmits Lymph Node Metastatic Capacity Between Gastric Cancer Cells via YAP-CPT1A-Mediated FAO Reprogramming Open
Background Lymph node metastasis (LNM) commonly occurs in gastric cancer (GC) and is tightly associated with poor prognosis. Exosome-mediated lymphangiogenesis has been considered an important driver of LNM. Whether exosomes directly trans…
View article: Decreased Incidence of Influenza During the COVID-19 Pandemic
Decreased Incidence of Influenza During the COVID-19 Pandemic Open
Yong Lu,1 Yiping Wang,1 Can Shen,1 Jianping Luo,1 Wanjun Yu2 1Laboratory Medicine Center, The Affiliated People’s Hospital of Ningbo University, Ningbo, 315040, People’s Republic of China; 2Department of Respiration, The Affiliated People’…
View article: Surgery and Surgery Approach Affect Survival of Patients With Stage I-IIA Small-Cell Lung Cancer: A Study Based SEER Database by Propensity Score Matching Analysis
Surgery and Surgery Approach Affect Survival of Patients With Stage I-IIA Small-Cell Lung Cancer: A Study Based SEER Database by Propensity Score Matching Analysis Open
Purpose The purpose of this study was to observe the significance of surgery and its approach in stage I-IIA (according to 8th American Joint Committee on Cancer Staging Manual) small-cell lung cancer (SCLC) using the Surveillance, Epidemi…
View article: Leukemia inhibitory factor is involved in the pathogenesis of NSCLC through activation of the STAT3 signaling pathway
Leukemia inhibitory factor is involved in the pathogenesis of NSCLC through activation of the STAT3 signaling pathway Open
Leukemia inhibitory factor (LIF) is a tumor promoter in several cancer types. However, the role of LIF in non-small cell lung cancer (NSCLC) remains to be explored. The present study explored the hypothesis that LIF is important for NSCLC …
View article: COVID-19 or treatment associated immunosuppression may trigger hepatitis B virus reactivation: A case report
COVID-19 or treatment associated immunosuppression may trigger hepatitis B virus reactivation: A case report Open
COVID-19 or treatment associated immunosuppression may trigger HBV reactivation.