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View article: OTHR-02. Engineered “of the shelf” allogeneic cellular therapies for metastatic brain tumors
OTHR-02. Engineered “of the shelf” allogeneic cellular therapies for metastatic brain tumors Open
Brain metastatic patients have multiple metastatic lesions or diagnostically challenging asymptomatic lesions, making surgery an inadequate therapeutic option. Given the challenges related to systemic delivery of a majority of therapeutic …
View article: Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers
Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers Open
This study presents a mechanism-based receptor-targeted cellular therapy approach to treat breast to brain metastasis.
View article: STEM-02. DEVELOPING BRAIN METASTATIC TUMOR MODELS FOR TARGETED STEM CELL THERAPY
STEM-02. DEVELOPING BRAIN METASTATIC TUMOR MODELS FOR TARGETED STEM CELL THERAPY Open
Metastatic brain tumors are the most commonly observed intracranial tumors, and 10–20% of adults with cancer develop brain metastasis. Characterizing clinically relevant brain metastasis models and exploring different delivery options to d…
View article: CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors
CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors Open
CRISPR-engineered receptor-specific self-targeted tumor cells demonstrate antitumor efficacy in vitro and in vivo.
View article: SCDT-26. STEM CELL LOADED ONCOLYTIC VIRUSES TRACK AND KILL METASTATIC BRAIN TUMORS
SCDT-26. STEM CELL LOADED ONCOLYTIC VIRUSES TRACK AND KILL METASTATIC BRAIN TUMORS Open
Brain metastatic patients have multiple metastatic lesions or diagnostically challenging asymptomatic lesions, making surgery an inadequate therapeutic option. Oncolytic viruses (OV) that selectively replicate in tumor cells are an emergin…
View article: Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas
Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas Open
Significance This study provides an insight into stem cell-based oncolytic virus therapies for advanced melanoma tumors that have metastasized into the brain by developing clinically relevant mouse tumor models and testing the fate and eff…