Wanping Geng
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View article: Distribution patterns and determinants of the lens thickness-to-anterior chamber depth ratio in cataract patients
Distribution patterns and determinants of the lens thickness-to-anterior chamber depth ratio in cataract patients Open
Background The lens thickness-to-anterior chamber depth (LT/ACD) ratio remains underexplored, despite its significance in optimizing cataract surgical outcomes and stratifying the risk of potential complications in aging populations. Aim T…
View article: Distribution and determinants of lens biometrics in cataract patients: Insights from biometrics and implications for surgical precision
Distribution and determinants of lens biometrics in cataract patients: Insights from biometrics and implications for surgical precision Open
Distributions of lens-specific biometrics varied with sex, age, and AL, and the lens-specific biometrics were correlated to similar but also distinct determinants in bilateral eyes. Our study provides a better understanding of the signific…
View article: 763 Initial results from phase I dose escalation trial of CAN1012 in patients with solid tumor malignancies
763 Initial results from phase I dose escalation trial of CAN1012 in patients with solid tumor malignancies Open
Background CAN1012 is a selective Toll-like receptor 7 (TLR7) agonist whose receptor locates in intracellular endosomes of plasmacytoid dendritic cells (pDC). Upon binding to TLR7 agonist, pDC secret high levels of type I interferons and o…
View article: 1171 CAN1012: a selective and potent TLR7 agonist with strong antitumoral properties mediated by localized innate immune activation
1171 CAN1012: a selective and potent TLR7 agonist with strong antitumoral properties mediated by localized innate immune activation Open
Background Toll-like receptors (TLRs) are commonly expressed on innate immune cells such as macrophages and dendritic cells (DC), and they play crucial roles in 1) mediating the first-line innate immune response against a wide variety of p…