Wanqian Li
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View article: Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults
Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults Open
Background Brominated flame retardants (BFRs), widely applied in fire prevention, are persistent environmental pollutants. Accumulating evidence indicates that BFRs can trigger inflammatory responses in humans, potentially contributing to …
View article: Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation
Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation Open
View article: Body temperature drives azole tolerance in <i>Candida albicans</i> by hindering the autophagic degradation of Erg11
Body temperature drives azole tolerance in <i>Candida albicans</i> by hindering the autophagic degradation of Erg11 Open
Human body temperature has been shown to limit the antifungal efficacy of azoles; however, the precise mechanisms underlying this limitation remain insufficiently understood. In this study, we observed that brief exposure (24 h) to human b…
View article: Galactose Inhibits the Translation of Erg1 that Enhances the Antifungal Activities of Azoles Against Candida albicans
Galactose Inhibits the Translation of Erg1 that Enhances the Antifungal Activities of Azoles Against Candida albicans Open
Background/Objectives: The diminished efficacy of azoles in treating fungal infections is attributed to the emergence of resistance among pathogenic fungi. Employing a synergistic approach with other compounds to enhance the antifungal act…
View article: Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities
Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities Open
Azole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. We find that the amino acids V234, F235 an…
View article: Stimulation of Soluble Guanylyl Cyclase (sGC) by Cinaciguat Attenuates Sepsisinduced Cardiac Injury
Stimulation of Soluble Guanylyl Cyclase (sGC) by Cinaciguat Attenuates Sepsisinduced Cardiac Injury Open
Background: Cinaciguat is a soluble Guanylyl Cyclase (sGC) activator that plays a crucial role in cardiovascular diseases. Previous research has shown that cinaciguat is involved in the progression of cardiomyopathy, which encompasses card…
View article: <i>Plasmodium</i> Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells
<i>Plasmodium</i> Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells Open
The integration of RNA- and DNA-based assays enables the investigation of disease dynamics, specifically assessing the role of asymptomatic or subclinical infections in malaria transmission. Circular RNAs (circRNAs), a distinct category of…
View article: Thermosensitive Hydrogel Integrated with Bimetallic Nano‐Enzymes for Modulating the Microenvironment in Diabetic Wound Beds
Thermosensitive Hydrogel Integrated with Bimetallic Nano‐Enzymes for Modulating the Microenvironment in Diabetic Wound Beds Open
Effective regulation and reconstruction of the microenvironment are critical for the regeneration of chronic wounds. Diabetic wounds, in particular, pose a significant clinical challenge due to increased oxidative stress and dysfunctional …
View article: PIMCOMP: An End-to-End DNN Compiler for Processing-In-Memory Accelerators
PIMCOMP: An End-to-End DNN Compiler for Processing-In-Memory Accelerators Open
Various processing-in-memory (PIM) accelerators based on various devices, micro-architectures, and interfaces have been proposed to accelerate deep neural networks (DNNs). How to deploy DNNs onto PIM-based accelerators is the key to explor…
View article: m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells
m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells Open
Retinal neovascularization (RNV) disease is one of the leading causes of blindness, yet the molecular underpinnings of this condition are not well understood. To delve into the critical aspects of cell-mediated angiogenesis, we analyzed ou…
View article: Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype
Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype Open
Uveitis is a vision-threatening disease primarily driven by a dysregulated immune response, with retinal microglia playing a pivotal role in its progression. Although the transcription factor EGR2 is known to be closely associated with uve…
View article: A 3D radially aligned nanofiber scaffold co-loaded with LL37 mimetic peptide and PDGF-BB for the management of infected chronic wounds
A 3D radially aligned nanofiber scaffold co-loaded with LL37 mimetic peptide and PDGF-BB for the management of infected chronic wounds Open
Diabetic foot ulcers, pressure ulcers, and bedsores can easily develop into chronic wounds with bacterial infections, complicating wound healing. This work reports a two-step strategy for treating infected chronic wounds. Firstly, LL37 mim…
View article: A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis Open
Background Vascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple diseases. Increased glycolytic rates and lactate accumulation are associated with pathological a…
View article: Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species
Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species Open
Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it. Consequently, con…
View article: YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes (Adv. Sci. 19/2024)
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes (Adv. Sci. 19/2024) Open
YY1 Lactylation Activated microglia in the retina are essential for the development of autoimmune uveitis. The center of this image presents YY1 lactylation (lactylation at 183 lysine of YY1), which stands between the normal microglia (res…
View article: YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes Open
Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune‐mediated diseases. Here, an increased YY…
View article: PIMSYN: Synthesizing Processing-in-memory CNN Accelerators
PIMSYN: Synthesizing Processing-in-memory CNN Accelerators Open
Processing-in-memory architectures have been regarded as a promising solution for CNN acceleration. Existing PIM accelerator designs rely heavily on the experience of experts and require significant manual design overhead. Manual design ca…
View article: OR11H1 Missense Variant Confers the Susceptibility to Vogt‒Koyanagi‒Harada Disease by Mediating Gadd45g Expression
OR11H1 Missense Variant Confers the Susceptibility to Vogt‒Koyanagi‒Harada Disease by Mediating Gadd45g Expression Open
Vogt‒Koyanagi‒Harada (VKH) disease is a severe autoimmune disease. Herein, whole‐exome sequencing (WES) study are performed on 2,573 controls and 229 VKH patients with follow‐up next‐generation sequencing (NGS) in a collection of 2,380 con…
View article: Wood-Derived Continuously Oriented Channels Coupled with Tunable Built-In Electric Fields for Efficient Oxygen Evolution
Wood-Derived Continuously Oriented Channels Coupled with Tunable Built-In Electric Fields for Efficient Oxygen Evolution Open
View article: Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity
Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity Open
Candida albicans filamentation plays a significant role in developing both mucosal and invasive candidiasis, making it a crucial virulence factor. Consequently, exploring and identifying inhibitors that impede fungal hyphal formation prese…
View article: Mathematical Framework for Optimizing Crossbar Allocation for ReRAM-based CNN Accelerators
Mathematical Framework for Optimizing Crossbar Allocation for ReRAM-based CNN Accelerators Open
The resistive random-access memory (ReRAM) has widely been used to accelerate convolutional neural networks (CNNs) thanks to its analog in-memory computing capability. ReRAM crossbars not only store layers’ weights, but also perform in-sit…
View article: Global lactylome reveals lactylation-dependent mechanisms underlying T <sub>H</sub> 17 differentiation in experimental autoimmune uveitis
Global lactylome reveals lactylation-dependent mechanisms underlying T <sub>H</sub> 17 differentiation in experimental autoimmune uveitis Open
Dysregulation of CD4 + T cell differentiation is linked to autoimmune diseases. Metabolic reprogramming from oxidative phosphorylation to glycolysis and accumulation of lactate are involved in this process. However, the underlying mechanis…
View article: A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing
A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing Open
Vogt–Koyanagi–Harada (VKH) disease is a leading cause of blindness in young and middle-aged people. However, the etiology of VKH disease remains unclear. Here, we performed the first trio-based whole-exome sequencing study, which enrolled …
View article: PIMCOMP: A Universal Compilation Framework for Crossbar-based PIM DNN Accelerators
PIMCOMP: A Universal Compilation Framework for Crossbar-based PIM DNN Accelerators Open
Crossbar-based PIM DNN accelerators can provide massively parallel in-situ operations. A specifically designed compiler is important to achieve high performance for a wide variety of DNN workloads. However, some key compilation issues such…
View article: Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization Open
Apigenin can ameliorate retinal inflammation in IRBP induced autoimmune uveitis through inhibiting microglia M1 pro-inflammatory polarization via TLR4/MyD88 pathway.
View article: YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2
YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2 Open
View article: Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice
Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice Open
Fibroblast growth factor-18 (FGF18) has diverse organ development and damage repair roles. However, its role in cardiac homeostasis following hypertrophic stimulation remains unknown. Here we investigate the regulation and function of the …
View article: SOX2‐positive retinal stem cells are identified in adult human pars plicata by single‐cell transcriptomic analyses
SOX2‐positive retinal stem cells are identified in adult human pars plicata by single‐cell transcriptomic analyses Open
Stem cell therapy is a promising strategy to rescue visual impairment caused by retinal degeneration. Previous studies have proposed controversial theories about whether in situ retinal stem cells (RSCs) are present in adult human eye tiss…
View article: A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols
A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols Open
Fluconazole (FLC) tolerance increases the frequency of acquired FLC resistance, and a high FLC tolerance level is associated with persistent candidemia. Multiple functional proteins, such as calcineurin, heat shock protein 90 (Hsp90), and …
View article: FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis
FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis Open
Uveitis, a vision-threatening inflammatory disease worldwide, is closely related to resident microglia. Retinal microglia are the main immune effector cells with strong plasticity, but their role in uveitis remains unclear. N6-methyladenos…