Explanipedia

Naganishia albidus Causing Perioral Cutaneous Infection: A Rare Case Easily Misdiagnosed Open

Kaisu Pan, Dong-Hui Lu, Weixuan Wu, Ping Luo, Liuwei Liao , et al. · 2025

Cutaneous cryptococcosis is rarely caused by Naganishia albidus, especially in immunocompetent individuals. We report a unique case of perioral cutaneous infection in a 37-year-old male with scattered erythematous, pruritic, and sca…

The kinase Bud32 regulates iron homeostasis in fungal pathogen Cryptococcus neoformans Open

Yuanyuan Ma, Bo Pan, Wenzhi Lei, Wenjie Fang, Weihua Pan , et al. · 2025

Introduction The ability to acquire iron and maintain iron homeostasis is crucial for the virulence of the human pathogenic fungus Cryptococcus neoformans . This study investigates the role of Bud32, a core virulence kinase and component o…

A six-year retrospective study on the causative agents of onychomycosis in China: the emergence of dematiaceous fungi Open

Xin Ye, Jun Tian, Wanqing Liao, Weihua Pan, Zhe Liu , et al. · 2025

Introduction Onychomycosis, a common nail disease, is caused by a diverse range of pathogens worldwide. However, the epidemiology and pathogen profile of onychomycosis in China remain insufficiently characterized. This study aimed to inves…

Global, Regional, and National Burden of Pulmonary Fungal Infections 1990–2021 Open

Ying Xia, Weiwei Jiang, Xinlin Zhu, Bo Pan, Tianyang Chen , et al. · 2025

Rationale: The lungs are the most prevalent site for invasive fungal infections, and the diagnosis and treatment of pulmonary fungal infections (PFIs) pose significant challenges, accompanied by a substantial disease burden. Global …

Profiling Drug Susceptibility and Species Identification of Aspergillus Isolates From Patients With Superficial Infection Open

Yahui Feng, Zhichao Zhang, Wenjie Fang, Sisi Wang, Jianfeng Zhang , et al. · 2025

Background Aspergillus infections pose significant challenges in clinical management due to rising resistance rates and limited diagnostic accuracy. Superficial infections, particularly in immunocompetent individuals, are often understudie…

A human skin microbiome reference catalog and the skin microbial landscape of plateau adults Open

Yi Liu, Zhiming Li, Chao Zhang, Bo Li, Weiwei Jiang , et al. · 2025

Comprehensive reference genomes are needed for the classification and functional characterization of the human skin microbiota. Here, we established human skin microbiome genome (HSMG) and protein (HSMP) catalogs by integrating 739 newly s…

Corrigendum: Ribosomal protein L40e fused with a ubiquitin moiety is essential for the vegetative growth, morphological homeostasis, cell cycle progression, and pathogenicity of Cryptococcus neoformans Open

Jingyu Zhao, Yali Yang, Yibin Fan, Jiu Yi, Chao Zhang , et al. · 2025

[This corrects the article DOI: 10.3389/fmicb.2020.570269.].

Trem2 acts as a non‐classical receptor of interleukin‐4 to promote diabetic wound healing Open

Xinlin Zhu, Chao Zhang, Weiwei Jiang, Zhaoxiang Zeng, Keming Zhang , et al. · 2024

Background The immunoglobulin superfamily protein Trem2 (triggering receptor expressed on myeloid cells 2) is primarily expressed on myeloid cells where it functions to regulate macrophage‐related immune response induction. While macrophag…

A single gene mutation underpins metabolic adaptation and acquisition of filamentous competence in the emerging fungal pathogen Candida auris Open

Yuchen Deng, Ming Xu, Shuaihu Li, Jian Bing, Qiushi Zheng , et al. · 2024

Filamentous cell growth is a vital property of fungal pathogens. The mechanisms of filamentation in the emerging multidrug-resistant fungal pathogen Candida auris are poorly understood. Here, we show that exposure of C . auris to glycerol …

X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway Open

Mingwei Du, Xin-Lin Zhu, D Zhang, Xianzhen Chen, Lihua Yang , et al. · 2024

BACKGROUND Diabetic foot ulcers (DFU), as severe complications of diabetes mellitus (DM), significantly compromise patient health and carry risks of amputation and mortality. AIM To offer new insights into the occurrence and development of…

Galleria mellonella in vitro model for chromoblastomycosis shows large differences in virulence between isolates Open

Dongmei Shi, Zhiya Yang, Wanqing Liao, Chen Liu, Liang Zhao , et al. · 2024

Background Chromoblastomycosis is the World Health Organization (WHO)-recognized fungal implantation disease that eventually leads to severe mutilation. Cladophialophora carrionii ( C. carrionii ) is one of the agents. However, the pathoge…

Disseminated Cryptococcosis Involving Skin and Lung in an Immunocompromised Patient After Kidney Transplantation: A Case Report Open

Yuanyang Shi, Hua Zhang, Yinuo Liu, Wenjie Fang, Ying Xia , et al. · 2023

Cryptococcus neoformans can cause detrimental cryptococcosis and other severe complications, especially in immunocompromised populations. Disseminated cryptococcosis in organ transplantation patients is extremely rare and often involves lu…

Progress in the application of nanoparticles for the treatment of fungal infections: A review Open

Xinlin Zhu, You-Ming Chen, Dan Yu, Wenjie Fang, Wanqing Liao , et al. · 2023

The burden of fungal infections on human health is increasing worldwide. Aspergillus, Candida, and Cryptococcus are the top three human pathogenic fungi that are responsible for over 90% of infection-related deaths. Mo…

XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway Open

Xin-Lin Zhu, Dongying Hu, Zhaoxiang Zeng, Weiwei Jiang, Tianyang Chen , et al. · 2023

Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature death. Although some diabetic complications have decreased in the developed world, the major…

Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study Open

Junqi Wu, Chongwu Li, Peigen Gao, Chenhong Zhang, Pei Zhang , et al. · 2023

Phaeohyphomycosis caused by Corynespora cassiicola , a plant pathogen worldwide Open

Dongying Hu, Weiwei Jiang, Xinlin Zhu, Qing Hou, Chen Min , et al. · 2023

Although rare, trans-kingdom infection features an interesting infection biology concept, in which highly versatile pathogenic attributes allow successful infections in evolutionarily highly divergent species. Corynespora cassiicola…

Diagnosis of invasive fungal infections: challenges and recent developments Open

Wenjie Fang, Junqi Wu, Mingrong Cheng, Xinlin Zhu, Mingwei Du , et al. · 2023

Cryptococcus neoformans, a global threat to human health Open

Youbao Zhao, Leixin Ye, Fujie Zhao, Lanyue Zhang, Zhenguo Lü , et al. · 2023

Gut microbiota associated with cryptococcal meningitis and dysbiosis caused by anti-fungal treatment Open

Hang Li, Lei Zhang, Keming Zhang, Yue Huang, Yi Liu , et al. · 2023

The gut microbiota is a dynamic and highly diverse microbial ecosystem that affects many aspects of the host’s physiology. An improved understanding of the gut microbiota could lead to better strategies for the diagnosis and therapy of cry…

TREM2 as a Potential Immune-Related Biomarker of Prognosis in Patients with Skin Cutaneous Melanoma Microenvironment Open

Xinlin Zhu, Zhaoxiang Zeng, Min Chen, Xianzhen Chen, Dongying Hu , et al. · 2023

Background. The skin cutaneous melanoma (SKCM) is a devastating form of skin cancer triggered by genetic and environmental factors, and the incidence of SKCM has rapidly increased in recent years. Immune infiltration of the tumor microenvi…

Editorial: Immune interactions with pathogenic and commensal fungi Open

Wenjie Fang, Carolina Coelho, Cunwei Cao, Lei Zhang, Wanqing Liao · 2023

fungi interactions with the host immunity as well as new strategies and recent updates on antifungal 33 immunity. 34Neutrophils is an essential component of the host innate immunity against fungal infections. Besides 35 phagocytosis, degra…

Trem2 Promotes Diabetic Wound Healing Via Macrophage-Fibroblast Regulating Hierarchy in a Lif Dependent Way Open

Xinlin Zhu, Chao Zhang, Weiwei Jiang, Zhaoxiang Zeng, You-Ming Chen , et al. · 2023

Immune Interactions with Pathogenic and Commensal Fungi Open

Wanqing Liao, Cunwei Cao, Carolina Coelho, Wenjie Fang · 2023

EXPERIMENTAL INVESTIGATION ON MECHANICAL PROPERTIES OF GRADE 1670 STEEL WIRES AT AND AFTER ELEVATED TEMPERATURE Open

Liliang Wang, Hong Wei Liu, Dong Hua, X Liu High, Wenbin Wang , et al. · 2022

Grade 1670 steel wires were selected for elevated-temperature and post-elevated-temperature tensile tests. The test data were analyzed through comparison with the results in existing literatures. The elevated-temperature test results indic…

Comparison of mechanical behavior between longitudinal lap-welded joints and transverse fillet welded joints of high strength steel Open

Meng Zhang, Weihao Liu, Lei Zhu, Dongliang Wang, J Wang , et al. · 2022

Mechanical behavior of twenty-eight longitudinal lap-welded joints made of high strength steels (HSS) under tension load was investigated by experimental study. Weaknesses due to traditional deformation measurements for fillet welded joint…

Functionalization of Nanomaterials for Skin Cancer Theranostics Open

Chao Zhang, Xinlin Zhu, Shuming Hou, Weihua Pan, Wanqing Liao · 2022

Skin cancer has drawn attention for the increasing incident rates and high morbidity worldwide. Timely diagnosis and efficient treatment are of paramount importance for prompt and effective therapy. Thus, the development of novel skin canc…

Evolutionary Relationships, Phylogeographic Patterns, and a Hypothesis for Air- and Sea-driven Global Spread of Chromoblastomycosis by Etiological Fonsecaea Agents Open

huiWei Wang, Juan Hao, Liangqi Cai, Min Chen, Wenjie Fang , et al. · 2022

Fonsecaea spp. is the most common pathogen underlying chromoblastomycosis. However, many aspects of its evolutionary history are not fully understood, and a timescale for its diversification is lacking . Here, we propose, explain, and vali…

Genotyping and Drug Resistance Profile of Clinical Isolates of Candida albicans from Vulvovaginal Candidiasis in the Eastern China Open

Nan Hong, Lei Yan, Huan Chen, Xiaofei Chen, Clement K. M. Tsui , et al. · 2022

A total of 244 Candida albicans isolates recovered from vulvovaginal candidiasis (VVC) patients in Suzhou, Eastern China, were investigated. According to CLSI documents M27-A4 and M59-3ed/M60-2ed, the MIC geometric means of nine antifungal…

In Situ Detection of Extracellular Polymeric Substances and Metal Ions at the Microbe-Mineral Interface During Bioleaching of Chalcopyrite by Moderate Thermophiles Open

Weimin Zeng, Zhiru Liu, Wanqing Liao, Jinju Cheng, Xueling Wu , et al. · 2022

Phenotypic Switching and Filamentation in Candida haemulonii, an Emerging Opportunistic Pathogen of Humans Open

Yuchen Deng, Shuaihu Li, Jian Bing, Wanqing Liao, Tao Li · 2021

The capacity to switch between distinct cell types, known as phenotypic switching, is a common strategy adopted by Candida species to adapt to diverse environments. Despite considerable studies on phenotypic plasticity of various Candida s…

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