Wei Han
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View article: Simple Spray Preparation of Multifunctional Organic–Inorganic Hybrid Coatings for Surface Strengthening of Flat Thin-Sheet Materials
Simple Spray Preparation of Multifunctional Organic–Inorganic Hybrid Coatings for Surface Strengthening of Flat Thin-Sheet Materials Open
To enhance the mechanical performance and surface hydrophobicity of flat thin-sheet materials, we have developed a facile, environmentally benign, and low-cost synthesis strategy for fabricating a robust waterborne superhydrophobic coating…
View article: Triglyceride-glucose index and mortality in congestive heart failure with diabetes: a machine learning predictive model
Triglyceride-glucose index and mortality in congestive heart failure with diabetes: a machine learning predictive model Open
Background The triglyceride-glucose (TyG) index serves as a marker for insulin resistance. Research exploring the link between the TyG index and adverse outcomes among patients suffering from congestive heart failure (CHF) and diabetes mel…
View article: Phonon-mediated synergistic coupling induced superconductivity in 2D Mn3B5: A first-principles prediction
Phonon-mediated synergistic coupling induced superconductivity in 2D Mn3B5: A first-principles prediction Open
Two-dimensional (2D) superconductors have garnered significant attention due to their critical roles in electronics, energy applications, and advanced technologies, making the exploration of novel 2D superconducting materials a research fr…
View article: A Hybrid UA–CG Force Field for Aggregation Simulation of Amyloidogenic Peptide via Liquid-like Intermediates
A Hybrid UA–CG Force Field for Aggregation Simulation of Amyloidogenic Peptide via Liquid-like Intermediates Open
Elucidating amyloid formation inside biomolecular condensates requires models that resolve (i) local, chemistry specific contacts controlling β registry and (ii) mesoscale phase behavior and cluster coalescence on microsecond timescales—ca…
View article: Asymmetric Total Synthesis of Leptosphin C
Asymmetric Total Synthesis of Leptosphin C Open
A concise enantioselective total synthesis of leptosphine C (1) has been achieved. Our synthetic strategy features an unprecedented diastereo-/enantioselective Hajos-Parrish-Eder-Sauer-Wiechert (HPESW) reaction for construction of the AB r…
View article: Diffusion of Alkaline Metals in Two-Dimensional β1-ScSi2N4 and β2-ScSi2N4 Materials: A First-Principles Investigation
Diffusion of Alkaline Metals in Two-Dimensional β1-ScSi2N4 and β2-ScSi2N4 Materials: A First-Principles Investigation Open
The MA2Z4 family represents a class of two-dimensional materials renowned for their outstanding mechanical properties and excellent environmental stability. By means of elemental substitution, we designed two novel phases of ScSi2N4, namel…
View article: Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe feline chronic kidney disease
Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe feline chronic kidney disease Open
A 10-year-old neutered male Ragdoll cat presented with symptoms of anorexia, nausea, vomiting, lethargy, and progressive weight loss. Laboratory parameters and clinical signs led to a diagnosis of International Renal Interest Society (IRIS…
View article: Expression of Alanine-Serine-Cysteine Transporter 2 (ASCT2) and L-type Amino Acid Transporter 1 (LAT1) in Low-Grade and High-Grade Gliomas: An Analysis of Open-Access Immunohistochemical Data
Expression of Alanine-Serine-Cysteine Transporter 2 (ASCT2) and L-type Amino Acid Transporter 1 (LAT1) in Low-Grade and High-Grade Gliomas: An Analysis of Open-Access Immunohistochemical Data Open
In our small study conducted with open-access data, ASCT2 and LAT1 did not appear to have prognostic value. However, both ASCT2 and LAT1 staining were increased at the endothelium compared to normal brain tissue. These amino acid transport…
View article: Half-Metallic 2D ScSi<sub>2</sub>N<sub>4</sub> Phases with Non-Metal-Induced Ferromagnetism and Tunable Electronic and Optical Properties
Half-Metallic 2D ScSi<sub>2</sub>N<sub>4</sub> Phases with Non-Metal-Induced Ferromagnetism and Tunable Electronic and Optical Properties Open
Two-dimensional (2D) intrinsic half-metal materials facilitate spin filtering, low-energy dissipation, and enhanced signal integrity, making them highly desirable for next-generation nanoelectronics and quantum technologies. In this work, …
View article: Luteolin Potentially Alleviates Methamphetamine Withdrawal-Induced Negative Emotions and Cognitive Deficits Through the AKT/FOXO1/HO-1 Signaling Pathway in the Prefrontal Cortex and Caudate Putamen
Luteolin Potentially Alleviates Methamphetamine Withdrawal-Induced Negative Emotions and Cognitive Deficits Through the AKT/FOXO1/HO-1 Signaling Pathway in the Prefrontal Cortex and Caudate Putamen Open
Methamphetamine (METH) misuse-induced affective and cognitive dysfunctions cause severe global health and economic burdens. However, the mechanisms underlying METH withdrawal-induced negative emotions and cognitive deficits, as well as the…
View article: Luteolin Potentially Alleviates Methamphetamine Withdrawal-Induced Negative Emotions and Cognitive Deficits Through the AKT/FOXO1/HO-1 Signaling Pathway in the Prefrontal Cortex and Caudate Putamen
Luteolin Potentially Alleviates Methamphetamine Withdrawal-Induced Negative Emotions and Cognitive Deficits Through the AKT/FOXO1/HO-1 Signaling Pathway in the Prefrontal Cortex and Caudate Putamen Open
Methamphetamine (METH) misuse-induced affective and cognitive dysfunctions cause severe global health and economic burdens. However, the mechanisms underlying METH withdrawal-induced negative emotions and cognitive deficits, as well as the…
View article: Divergent Total Syntheses of 7,20‐Epoxy, 3,20‐Epoxy, and 6,7‐<i>seco‐ent</i>‐Kaurane Diterpenoids
Divergent Total Syntheses of 7,20‐Epoxy, 3,20‐Epoxy, and 6,7‐<i>seco‐ent</i>‐Kaurane Diterpenoids Open
The genus Isodon is a well‐known traditional medicinal herb that serves as a rich source of cytotoxic ent ‐kaurane diterpenoids, which bear the same tetracyclic core of ent ‐kaurane with different oxygenation, bond‐cleavage, and rearrangem…
View article: Enzyme mimics of bimetallic nanoclusters for detection of trypsin
Enzyme mimics of bimetallic nanoclusters for detection of trypsin Open
Detection of trypsin is very important for human health. In this work, bovine serum albumin protected OsAg nanoclusters (BSA-OsAg NCs) were prepared. The ratio of Ag element in the nanoclusters could be regulated by controlling the reagent…
View article: A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2 channels
A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2 channels Open
Mechanosensitive PIEZO channels are thought to open their pore through tension-induced flattening of large transmembrane arm domains. Yet, the structural basis of this activation remains unclear. Here, we uncover the conformational couplin…
View article: The Effect of the Pore Size of TiO2 Aerogel on the Photocatalytic Decomposition of Formaldehyde
The Effect of the Pore Size of TiO2 Aerogel on the Photocatalytic Decomposition of Formaldehyde Open
TiO2 aerogels have been employed for the degradation of formaldehyde (HCHO) via the photocatalytic generation of reactive oxygen species (ROS) (O2−, ·OH), and its pore size plays a crucial role in affecting the decomposition efficiency. Ho…
View article: Reposition pathways of GTP in <i>orthoflavivirus</i> NS5-methyltransferase revealed by enhanced molecular dynamics simulations
Reposition pathways of GTP in <i>orthoflavivirus</i> NS5-methyltransferase revealed by enhanced molecular dynamics simulations Open
Reposition pathways of GTP in orthoflavivirus NS5-methyltransferase (MTase) relevant to the N 7 -MTase reaction have been modelled by two-stage enhanced molecular dynamics simulations.
View article: Europium probe binding to serum albumin and α<sub>1</sub>-AGP, key importance of configuration, charge and size complementarity
Europium probe binding to serum albumin and α<sub>1</sub>-AGP, key importance of configuration, charge and size complementarity Open
Combined luminescence studies and stochastic molecular dynamics simulations demonstrate how cooperative hydrophobic binding and reversible metal ion coordination of Glu-188 in human serum albumin combine to enhance protein binding affinity.
View article: Observation of quantized vortex in an atomic Bose-Einstein condensate at Dirac point with emergent spin-orbit coupling
Observation of quantized vortex in an atomic Bose-Einstein condensate at Dirac point with emergent spin-orbit coupling Open
When two or more energy bands become degenerate at a singular point in the momentum space, such singularity, or ``Dirac points", gives rise to intriguing quantum phenomena as well as unusual material properties. Systems at the Dirac points…
View article: Selective Protonation of Catalytic Dyad for γ-Secretase-Mediated Hydrolysis Revealed by Multiscale Simulations
Selective Protonation of Catalytic Dyad for γ-Secretase-Mediated Hydrolysis Revealed by Multiscale Simulations Open
γ-Secretase plays a crucial role in producing disease-related amyloid-β proteins by cleaving the amyloid precursor protein (APP). The enzyme employs its catalytic dyad containing two aspartates (Asp257 and Asp385) to hydrolyze the substrat…
View article: Simulations of Functional Motions of Super Large Biomolecules with a Mixed-Resolution Model
Simulations of Functional Motions of Super Large Biomolecules with a Mixed-Resolution Model Open
Many large protein machines function through an interplay between large-scale movements and intricate conformational changes. Understanding functional motions of these proteins through simulations becomes challenging for both all-atom and …
View article: Identification of Potential Targets of Stress Cardiomyopathy by a Machine Learning Algorithm
Identification of Potential Targets of Stress Cardiomyopathy by a Machine Learning Algorithm Open
Background: Stress cardiomyopathy (SCM) is a reversible, self-limiting condition that manifests as left ventricular insufficiency. The incidence of stress cardiomyopathy has increased because of increasing mental and social stress, but the…
View article: Intramolecular CH⋯π attraction mediated conformational polymorphism of constrained helical peptides
Intramolecular CH⋯π attraction mediated conformational polymorphism of constrained helical peptides Open
In nature, biochemical processes depend on polymorphism, a phenomenon by which discrete biomolecules can adopt specific conformations based on their environment.
View article: RaftGP: Random Fast Graph Partitioning
RaftGP: Random Fast Graph Partitioning Open
Graph partitioning (GP), a.k.a. community detection, is a classic problem that divides the node set of a graph into densely-connected blocks. Following prior work on the IEEE HPEC Graph Challenge benchmark and recent advances in graph mach…
View article: Suppl Figures from Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes
Suppl Figures from Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes Open
Supplemental Figures 1-5.
View article: Table S4 from Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes
Table S4 from Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes Open
Differentially accessible regions
View article: Suppl Figures from Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes
Suppl Figures from Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes Open
Supplemental Figures 1-5.
View article: Table S1 from Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes
Table S1 from Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes Open
NGS data statistics