Fang Wu
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View article: Paradoxical regulation of IGF2 in promoting lipid metabolism in adipose tissues
Paradoxical regulation of IGF2 in promoting lipid metabolism in adipose tissues Open
Metabolic diseases such as diabetes, obesity, and dyslipidemia pose major public health challenges globally. While the insulin-like growth factor 2 (IGF2) gene is known to be involved in various physiological processes, its precise role in…
View article: PMN-MDSC: A Culprit Behind Immunosenescence and Increased Susceptibility to Clostridioides difficile Infection During Aging
PMN-MDSC: A Culprit Behind Immunosenescence and Increased Susceptibility to Clostridioides difficile Infection During Aging Open
Susceptibility to pathogens in the elderly is heightened with age, largely because of immunosenescence. As an immune regulatory organ, bone marrow creates immune cells that move to other organs and tissues through the blood. Despite the si…
View article: Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis
Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis Open
Plant-derived exosome-like nanoparticles (ELNs) have been proposed as a novel therapeutic tool for preventing human diseases. However, the number of well-verified plant ELNs remains limited. In this study, the microRNAs in ELNs derived fro…
View article: Bacillamide F, Extracted from Marine Bacillus atrophaeus C89, Preliminary Effects on Leukemia Cell Lines
Bacillamide F, Extracted from Marine Bacillus atrophaeus C89, Preliminary Effects on Leukemia Cell Lines Open
Developing new treatments for leukemia is essential since current therapies often suffer from drug resistance and toxicity. Bacillamides are very promising, naturally occurring compounds with various bioactivities. In the present study, we…
View article: Retrospective analysis of the 18F-FDG PET/CT cutoff value for metabolic parameters was performed as a prediction model to evaluate risk factors for endometrial cancer.
Retrospective analysis of the 18F-FDG PET/CT cutoff value for metabolic parameters was performed as a prediction model to evaluate risk factors for endometrial cancer. Open
Purpose The study retrospectively analyzed the accuracy and predictive ability of preoperative integrated whole-body 18 F-FDG PET/CT for the assessment of high-risk factors in patients with endometrial carcinoma (EC). Materials and methods…
View article: IGF2 deficiency causes mitochondrial defects in skeletal muscle
IGF2 deficiency causes mitochondrial defects in skeletal muscle Open
Exercise training improves muscle fitness in many aspects, including induction of mitochondrial biogenesis and maintenance of mitochondrial dynamics. The insulin-like growth factors were recently proposed as key regulators of myogenic fact…
View article: High-throughput tandem-microwell assay for ammonia repositions FDA-Approved drugs to <i>Helicobacter pylori</i> infection
High-throughput tandem-microwell assay for ammonia repositions FDA-Approved drugs to <i>Helicobacter pylori</i> infection Open
To date, little attempt has been made to develop new treatments for Helicobacter pylori ( H. pylori ), although the community is aware of the shortage of treatments for H. pylori . In this study, we developed a 192-tandem-microwell-based h…
View article: Comparative Analysis of Two Methods of Natural Gas Demand Forecasting
Comparative Analysis of Two Methods of Natural Gas Demand Forecasting Open
Based on the monthly dataset of natural gas demand and meteorological factors in heating season (November to next March) of Beijing from 2002 to 2013, an analysis of meteorological condition of natural gas fluctuation is done, which used b…
View article: LncRNA PVT1 Mediated by ZFP36L2 Regulates Myocardial Ischemia/Reperfusion Injury and Attenuates Mitochondrial Fusion and Fission via Activating miR-21-5p/MARCH5 Axis
LncRNA PVT1 Mediated by ZFP36L2 Regulates Myocardial Ischemia/Reperfusion Injury and Attenuates Mitochondrial Fusion and Fission via Activating miR-21-5p/MARCH5 Axis Open
BackgroundAmong several leading cardiovascular disorders, ischemia-reperfusion (I/R) injury causes severe manifestations including acute heart failure, inflammation, and systemic dysfunction. Recently, there has been increasing evidence su…
View article: Tnni1b-ECR183-d2, an 87 bp cardiac enhancer of zebrafish
Tnni1b-ECR183-d2, an 87 bp cardiac enhancer of zebrafish Open
Background Several heart malformations are associated with mutations in the regulatory regions of cardiac genes. Troponin I type 1b (tnni1b) is important for the formation of the atrioventricular canal in zebrafish hearts; however, the reg…
View article: Aberrant expression of miR‐29b‐3p influences heart development and cardiomyocyte proliferation by targeting NOTCH2
Aberrant expression of miR‐29b‐3p influences heart development and cardiomyocyte proliferation by targeting NOTCH2 Open
Objectives microRNA‐29 (miR‐29) family have shown different expression patterns in cardiovascular diseases. Our study aims to explore the effect and mechanism of miR‐29 family on cardiac development. Materials and methods A total of 13 pat…
View article: Identification of a 42‐bp heart‐specific enhancer of the <i>notch1b</i> gene in zebrafish embryos
Identification of a 42‐bp heart‐specific enhancer of the <i>notch1b</i> gene in zebrafish embryos Open
Background NOTCH1 plays a key role in the differentiation of ventricles, and mutations are strongly associated with both sporadic and familial bicuspid aortic valves. However, few heart‐specific enhancers have been identified to date. Resu…
View article: A new laminopathy caused by an Arg133/Leu mutation in <i>lamin A/C</i> and the effects thereof on adipocyte differentiation and the transcriptome
A new laminopathy caused by an Arg133/Leu mutation in <i>lamin A/C</i> and the effects thereof on adipocyte differentiation and the transcriptome Open
We report a new laminopathy that includes generalized lipoatrophy, insulin-resistant diabetes, micrognathia and biopsy-proven, focal segmental glomerulosclerosis in a female, caused by a de novo heterozygous mutation R133L in the lamin A/C…
View article: Combinatorial genetic replenishments in myocardial and outflow tract tissues restore heart function in <i>tnnt2</i> mutant zebrafish
Combinatorial genetic replenishments in myocardial and outflow tract tissues restore heart function in <i>tnnt2</i> mutant zebrafish Open
Cardiac muscle troponin T (Tnnt2) mediates muscle contraction in response to calcium ion dynamics, and Tnnt2 mutations are associated with multiple types of cardiomyopathy. Here, we employed a zebrafish model to investigate the genetic rep…
View article: Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase
Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase Open
We identify three submicromolar inhibitors with new chemical scaffolds for cystathionine γ-lyase (CSE) by a tandem-well-based high-throughput assay. NSC4056, the most potent inhibitor with an IC50 of 0.6 μM, which is also known as aurintri…
View article: Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor
Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor Open
Metabolic syndrome (MetS) is characterized by a cluster of metabolic disorders including obesity, dyslipidemia, hyperglycemia, and hypertension. Here, we report that 27 microRNAs were found to be expressed differently in serum and urine sa…
View article: A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis
A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis Open
Cystathionine β-synthase (CBS) is responsible for the first enzymatic reaction in the transsulfuration pathway of sulfur amino acids. The molecular function and mechanism of CBS as well as that of transsulfuration pathway remain ill-define…
View article: The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein
The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein Open
Mucin-type O-glycosylation is the most abundant type of O-glycosylation. It is initiated by the members of the polypeptide N-acetyl-α-galactosaminyltransferase (ppGalNAc-T) family and closely associated with both physiological and patholog…
View article: Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production
Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production Open
Recent evidence suggests involvement of biometal homeostasis in the pathological mechanisms in Alzheimer's disease (AD). For example, increased intracellular copper or zinc has been linked to a reduction in secreted levels of the AD-causin…
View article: Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells
Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells Open
Deregulation of the TAM (TYRO3, AXL, and MERTK) family of receptor tyrosine kinases (RTKs) has recently been demonstrated to predominately promote survival and chemoresistance of cancer cells. Intramembrane proteolysis mediated by presenil…
View article: The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat
The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat Open
LEPTIN (LEP) is a circulating hormone released primarily from white adipocytes and is crucial for regulating satiety and energy homeostasis in humans and animals. Using the CRISPR technology, we created a set of Lep mutant rats that carry …
View article: The essential role of matrix selection on the osteoblastic and chondrocytic differentiation of mesenchymal stem cell
The essential role of matrix selection on the osteoblastic and chondrocytic differentiation of mesenchymal stem cell Open
Event Abstract Back to Event The essential role of matrix selection on the osteoblastic and chondrocytic differentiation of mesenchymal stem cell Fang Wu1, Jing He1 and Bo Jiang1 1 Sichuan University, National Engineering Research Center f…
View article: The control of mesenchymal stem cell differentiation using matrix and induction media
The control of mesenchymal stem cell differentiation using matrix and induction media Open
Event Abstract Back to Event The control of mesenchymal stem cell differentiation using matrix and induction media Jing He1, Bo Jiang1, Ruijuan Yao1, Yao Wu1 and Fang Wu1 1 Sichuan University, National Engineering Research Center for Bioma…