Wei Ge
YOU?
Author Swipe
View article: Targeting Cend1-Atp5f1b interaction rescues mitochondrial dysfunction and ameliorates ischemic brain injury
Targeting Cend1-Atp5f1b interaction rescues mitochondrial dysfunction and ameliorates ischemic brain injury Open
Mitochondrial dysfunction is a critical contributor to neuronal damage in acute ischemic stroke (AIS), and targeting mitochondrial function represents a promising therapeutic strategy. This study unveils the pivotal role of Cend1 protein i…
View article: Optimized federated learning framework with RegNetZ and Swin-Transformer for multimodal pancreatic cancer detection1
Optimized federated learning framework with RegNetZ and Swin-Transformer for multimodal pancreatic cancer detection1 Open
Pancreatic cancer is among the most lethal malignancies, marked by aggressive progression, late diagnosis, and limited screening methods, resulting in a five-year survival rate of less than 10%. Early-stage tumors are especially challengin…
View article: PHF19 drives the formation of PRC2 clusters to enhance motility in TNBC cells
PHF19 drives the formation of PRC2 clusters to enhance motility in TNBC cells Open
Polycomb repressive complex 2 (PRC2) is a key regulator of transcriptional repression and chromatin organization, essential in development and disease. While its enzymatic activity is well characterized, the factors governing PRC2 subnucle…
View article: Ace2 mutation disrupts amino acid absorption, impairs growth, and alters microbiota dynamics in zebrafish
Ace2 mutation disrupts amino acid absorption, impairs growth, and alters microbiota dynamics in zebrafish Open
Angiotensin-converting enzyme 2 (Ace2) is a well-studied enzyme with important physiological functions in mammals. However, its roles in non-mammalian animals remain largely unexplored. This study investigates the function of Ace2 in zebra…
View article: Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation Open
Background Thyroid hormone (TH) signaling drives cardiomyocyte (CM) maturation in endothermic animals. Elevated TH levels, coupled with increased basal metabolism, promote CM cell cycle exit and polyploidization, thus limiting heart regene…
View article: Reconfigurable robust microrobot collectives with large force output enabled by gradient magnetic fields
Reconfigurable robust microrobot collectives with large force output enabled by gradient magnetic fields Open
Robot collectives offer a promising solution for complex assignments that are nearly impossible for individual robots to execute. In microscopic scenarios, organizing microrobot collectives is now governed by agent-agent physical interacti…
View article: A Novel High-Precision Imaging Radar for Quality Inspection of Building Insulation Layers
A Novel High-Precision Imaging Radar for Quality Inspection of Building Insulation Layers Open
In recent years, the building insulation layer peeling caused by quality problems has brought about safety hazards to human life. Existing means of non-destructive testing of building insulation layers, including laser scanning, infrared t…
View article: Evaluating the Effects of Neburon Exposure on Ovarian Folliculogenesis Using Zebrafish and Mouse Granulosa Cell Line
Evaluating the Effects of Neburon Exposure on Ovarian Folliculogenesis Using Zebrafish and Mouse Granulosa Cell Line Open
In zebrafish, AMH was identified as a critical target for reproductive disorders following neburon exposure. Despite the short half-lives of currently used pesticides, their metabolites might still have significant toxicological risks. Thi…
View article: DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis
DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis Open
Vascular development is a precisely controlled process, yet how it is spatiotemporally orchestrated remains enigmatic. We previously identified DEAD-box RNA helicase 24 (DDX24) as a pathogenic gene for multiorgan vascular anomalies. Here, …
View article: Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish
Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish Open
Climate-driven warming affects the reproduction of oviparous ectotherms. However, whether oviparous ectotherms possess a protection mechanism against heat stress for oocyte development, which is essential for maintaining the continuity of …
View article: PHF19 drives PRC2 sub-nuclear compartmentalization to promote motility in TNBC cells
PHF19 drives PRC2 sub-nuclear compartmentalization to promote motility in TNBC cells Open
Polycomb Repressive Complex 2 (PRC2) is a key regulator of chromatin architecture and transcriptional repression, playing essential roles in development and disease. While its enzymatic activity is well characterized, the molecular factors…
View article: Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis
Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis Open
Sex determination and differentiation in zebrafish involve a complex interaction of male and female-promoting factors. While Dmrt1 has been established as a critical male-promoting factor, the roles of Anti-Müllerian hormone (Amh) and andr…
View article: Outcomes of peripherally inserted central catheter vs conventional central venous catheters in hematological cancer patients: a systematic review and meta-analysis
Outcomes of peripherally inserted central catheter vs conventional central venous catheters in hematological cancer patients: a systematic review and meta-analysis Open
There is conflicting evidence on the risk of thrombosis between PICC and CVC when used for hematological cancer patients. There could be a tendency of higher risk of thrombosis with PICC which needs to be confirmed by further studies. Howe…
View article: The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity
The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity Open
Rotenone is a natural compound from plants. It is widely used in pesticides because of highly toxic to insects and fish. However, lots of research has reported that rotenone has neurotoxic effects in humans. It is confirmed there is a corr…
View article: Y box-binding protein 1 regulates zebrafish folliculogenesis partly through p21-mediated control of follicle cell proliferation
Y box-binding protein 1 regulates zebrafish folliculogenesis partly through p21-mediated control of follicle cell proliferation Open
Y box-binding protein 1 (Ybx1/ybx1) regulates gene expression through DNA/RNA binding. In zebrafish, Ybx1 is highly abundant in primary growth (PG) follicles in the ovary, but decreases precipitously as the follicles enter the secondary gr…
View article: Flavor compound geraniol induces inhibited nutrient utilization and developmental toxicity on embryonic–larval zebrafish
Flavor compound geraniol induces inhibited nutrient utilization and developmental toxicity on embryonic–larval zebrafish Open
Flavors are widely utilized in the food and oral pharmaceutical industry, particularly in products for children, to enhance palatability and promote ingestion willingness. The complex compositions of flavors potentially induce severer toxi…
View article: Aspirin reduces Ponatinib-induced cardiovascular toxic phenotypes and death in zebrafish
Aspirin reduces Ponatinib-induced cardiovascular toxic phenotypes and death in zebrafish Open
Our findings suggest that Aspirin exhibits the potential to reduce Ponatinib-induced cardiovascular toxicity.
View article: Mucosa‑associated lymphoid tissue lymphoma translocation protein 1 inhibitor, MI‑2, attenuates non‑small cell lung cancer cell proliferation, migration and invasion, and promotes apoptosis by suppressing the JNK/c‑JUN pathway
Mucosa‑associated lymphoid tissue lymphoma translocation protein 1 inhibitor, MI‑2, attenuates non‑small cell lung cancer cell proliferation, migration and invasion, and promotes apoptosis by suppressing the JNK/c‑JUN pathway Open
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitors are effective in attenuating the progression of several types of cancer. However, their role in lung cancer requires further investigation. Therefore, th…
View article: Transcriptomic Characterization of Key Factors and Signaling Pathways for the Regeneration of Partially Hepatectomized Liver in Zebrafish
Transcriptomic Characterization of Key Factors and Signaling Pathways for the Regeneration of Partially Hepatectomized Liver in Zebrafish Open
Liver regeneration induced by partial hepatectomy (PHx) has attracted intensive research interests due to the great significance for liver resection and transplantation. The zebrafish (Danio rerio) is an excellent model to study liver rege…
View article: Design and Characterization of a Dual‐Interval Elastic Force Sensor for Robot‐Assisted Microinjection
Design and Characterization of a Dual‐Interval Elastic Force Sensor for Robot‐Assisted Microinjection Open
Robot‐assisted microinjection has been widely implemented in the field of experimental biology research. Force perception is more accurate than visual feedback in determining the state of interaction between the micropipette and the biolog…
View article: Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts
Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts Open
A strong positive association has been observed between circulating anti-Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important because of the …
View article: Role of Y box-binding protein 1 (Ybx1/<i>ybx1</i>) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of cell cycle inhibitor p21 (<i>cdkn1a</i>)
Role of Y box-binding protein 1 (Ybx1/<i>ybx1</i>) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of cell cycle inhibitor p21 (<i>cdkn1a</i>) Open
Y box-binding protein 1 (YB-1; Ybx1/ ybx1 ) regulates transcription and translation of targeted genes through DNA/RNA-binding. Our research in zebrafish has revealed a high abundance of Ybx1 in the primary growth (PG) follicles in the ovar…
View article: Disruption of Thyroid Hormone Receptor Thrab Leads to Female Infertility in Zebrafish
Disruption of Thyroid Hormone Receptor Thrab Leads to Female Infertility in Zebrafish Open
Thyroid hormones (THs) T4 and T3 are vital for development, growth, and metabolism. Thyroid dysfunction can also cause problems in fertility, suggesting involvement of THs in reproduction. In zebrafish, there exist 2 forms of TH receptor a…
View article: Design of an automated robotic microinjection system for batch injection of zebrafish embryos and larvae
Design of an automated robotic microinjection system for batch injection of zebrafish embryos and larvae Open
This paper presents the design of a vision-based automated robotic microinjection system for batch injection of both zebrafish embryos and larvae. A novel visual recognition algorithm based on an automatic threshold and excessive dilatatio…
View article: Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis
Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis Open
As an oocyte-specific growth factor, bone morphogenetic protein 15 (BMP15) plays a critical role in controlling folliculogenesis. However, the mechanism of BMP15 action remains elusive. Using zebrafish as the model, we created a bmp15 muta…