Ward Ortmann
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View article: Cell-type specific cis-eQTLs in eight brain cell-types identifies novel risk genes for human brain disorders
Cell-type specific cis-eQTLs in eight brain cell-types identifies novel risk genes for human brain disorders Open
Most expression quantitative trait loci (eQTL) studies to date have been performed in heterogeneous brain tissues as opposed to specific cell types. To investigate the genetics of gene expression in adult human cell types from the central …
View article: Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus
Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus Open
Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence indicates a role for type I interferon (IFN) in SLE p…
View article: Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis
Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis Open
BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5 as a potential biomarker of clinic…
View article: Longitudinal analysis of mimic muscles in patients with Parkinson’s disease
Longitudinal analysis of mimic muscles in patients with Parkinson’s disease Open
Introduction Anne Heinzl et al. showed with the standardized sonography of mimic muscles of Parkinson's patients significantly reduced muscle cross-sectional areas (difference between contraction and resting value: ♂: 33.1 %, ♀: 36.7 %). T…
View article: The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression Open
An Aluring new autoantibody target Autoimmunity is the immune system's ultimate act of betrayal. Cells designed to protect against invading microbes suddenly target the host instead. In the autoimmune disease systemic lupus erythematosus, …
View article: Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in<i>PSEN1</i>With Familial Alzheimer Disease Among Caribbean Hispanics
Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in<i>PSEN1</i>With Familial Alzheimer Disease Among Caribbean Hispanics Open
Our 2-stage analysis revealed that SNX25, PDLIM3, and SORBS2 may serve as genetic modifiers of age at onset in both EOAD and LOAD.
View article: TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits
TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits Open
Despite the success of genome-wide association studies (GWAS) in detecting a large number of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of information on the causal genes leaves important challen…