Wareed Ahmed
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View article: The tyrosine kinase inhibitor GNF-7 targets senescent cells through allosteric activation of GCN2
The tyrosine kinase inhibitor GNF-7 targets senescent cells through allosteric activation of GCN2 Open
Summary The one-two-punch approach refers to the sequential administration of two different chemotherapies, the second of which targets cancer cells that resisted the initial treatment. To find such a second punch, we performed a chemical …
View article: Natural flavonoid apigenin and xanthoangelol E are potent antivirals against human metapneumovirus: an in-silico study
Natural flavonoid apigenin and xanthoangelol E are potent antivirals against human metapneumovirus: an in-silico study Open
Human metapneumovirus (hMPV) is one of the potential pandemic pathogens, and it is a concern for elderly subjects and immunocompromised patients. There is no vaccine or specific antiviral available for hMPV. We conducted an in-silico study…
View article: Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops
Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops Open
Telomeres are the nucleoprotein structures at chromosome ends. Telomeres are particularly sensitive to oxidative stress, which can induce telomere damage, shortening, and premature cellular senescence. How oxidative damage influences telom…
View article: Comparison of different diagnostic modalities for isolation of Mycobacterium Tuberculosis among suspected tuberculous lymphadenitis patients
Comparison of different diagnostic modalities for isolation of Mycobacterium Tuberculosis among suspected tuberculous lymphadenitis patients Open
Tuberculosis is a communicable disease with high morbidity and mortality rates in developing countries. The study's primary objective is to compare conventional methods such as acid-fast bacillus (AFB) culture and microscopy with rapid dia…
View article: SMCHD1 Promotes ATM-dependent DNA Damage Signaling and Repair of Uncapped Telomeres
SMCHD1 Promotes ATM-dependent DNA Damage Signaling and Repair of Uncapped Telomeres Open
SMCHD1 (structural maintenance of chromosomes flexible hinge domain containing protein 1) has been implicated in X-chromosome inactivation, imprinting and DNA damage repair. Mutations in SMCHD1 can also cause facioscapulohumoral muscular d…
View article: Physical and functional interaction between nucleoid‐associated proteins HU and Lsr2 of <i>Mycobacterium tuberculosis</i>: altered DNA binding and gene regulation
Physical and functional interaction between nucleoid‐associated proteins HU and Lsr2 of <i>Mycobacterium tuberculosis</i>: altered DNA binding and gene regulation Open
Summary Nucleoid‐associated proteins (NAPs) in bacteria contribute to key activities such as DNA compaction, chromosome organization and regulation of gene expression. HU and Lsr2 are two principal NAPs in Mycobacterium tuberculosis ( Mtb …
View article: Figure 4_ATM pS9181 IF
Figure 4_ATM pS9181 IF Open
HeLaS2=EVHeLaSg2_30=SMCHD1 KO1HeLaSg3_35=SMCHD1 KO2
View article: Figure 3_53BP1_IF-FISH
Figure 3_53BP1_IF-FISH Open
The data included here is used to report the finding that loss of SMCHD1 in shTRF2 depleted HeLa cells affects the DNA damage signalling. The data is part of figure 3B of the following manuscript https://www.biorxiv.org/content/10.1101/669…
View article: Figure 2B
Figure 2B Open
The data included here is used to report the finding that loss of SMCHD1 in shTRF2 depleted HeLa cells affects the telomere fusion frequency. The data is part of figure 2B of the following manuscript https://www.biorxiv.org/content/10.1101…
View article: Figure 1B and C
Figure 1B and C Open
The data included here is used to report the finding that loss of SMCHD1 in shTRF2 depleted HeLa cells affects the telomere fusion frequency. The data is part of figure 1B and C of the following manuscript https://www.biorxiv.org/content/1…
View article: Figure 3_gH2AX IF-FISH
Figure 3_gH2AX IF-FISH Open
The data included here is used to report the finding that loss of SMCHD1 in shTRF2 depleted HeLa cells affects the tnumber of gH2AX foci at telomere. The data is part of figure 1B and C of the following manuscript https://www.biorxiv.org/c…
View article: Figure 3_ATMpS9181_IF-FISH
Figure 3_ATMpS9181_IF-FISH Open
The data included here is used to report the finding that loss of SMCHD1 in shTRF2 depleted HeLa cells affects the number of ATMpS1981 foci. The data is part of figure 3 of the following manuscript https://www.biorxiv.org/content/10.1101/6…
View article: PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase
PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase Open
Telomerase counteracts telomere shortening and cellular senescence in germ, stem, and cancer cells by adding repetitive DNA sequences to the ends of chromosomes. Telomeres are susceptible to damage by reactive oxygen species (ROS), but the…
View article: Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase
Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase Open
Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accu…