Wariya Sanrattana
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View article: Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants
Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants Open
We provide a functional classification of SERPING1 gene variants suggesting that different SERPING1 variants drive the pathogenicity through different and in some cases overlapping molecular disease mechanisms. For a subset of gene variant…
View article: A reactive center loop–based prediction platform to enhance the design of therapeutic SERPINs
A reactive center loop–based prediction platform to enhance the design of therapeutic SERPINs Open
Significance Serine protease inhibitors (SERPINs) regulate vital physiological processes. Considerable research effort has gone into the development of SERPINs as therapeutic agents. One of the development goals is SERPIN modification for …
View article: Targeted SERPIN (TaSER): A dual‐action antithrombotic agent that targets platelets for SERPIN delivery
Targeted SERPIN (TaSER): A dual‐action antithrombotic agent that targets platelets for SERPIN delivery Open
The synergy between the individual properties of TaSER makes it a highly effective antithrombotic agent with possible clinical implications.
View article: Design and characterization of α1-antitrypsin variants for treatment of contact system–driven thromboinflammation
Design and characterization of α1-antitrypsin variants for treatment of contact system–driven thromboinflammation Open
Targeting natural anticoagulant proteins as a means to rebalance the hemostatic system is an emerging trend in the development of innovative therapeutic strategies for hemophilia. These 2 articles develop these concepts in the areas of hem…
View article: Antioxidant Properties of Unripe<i>Carica papaya</i>Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress
Antioxidant Properties of Unripe<i>Carica papaya</i>Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress Open
It has been proven that high consumption of fruit and vegetable lowers the risks of cardiovascular and other oxidative stress-related diseases. Here we evaluated the effects of a tropical fruit, unripe Carica papaya (UCP), on endothelial p…
View article: SERPINs—From Trap to Treatment
SERPINs—From Trap to Treatment Open
Excessive enzyme activity often has pathological consequences. This for example is the case in thrombosis and hereditary angioedema, where serine proteases of the coagulation system and kallikrein-kinin system are excessively active. Serin…