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View article: A genetically engineered vertebrate animal model of <i>NAA15</i>-related heart disease uncovers myocardial growth, contractility, and mitochondrial defects
A genetically engineered vertebrate animal model of <i>NAA15</i>-related heart disease uncovers myocardial growth, contractility, and mitochondrial defects Open
Delineating the genetic and environmental instigators of congenital heart disease (CHD), affecting up to 1% of newborns, will improve preventative, diagnostic, and therapeutic efforts to mitigate the disease. Although mutations in the N-al…
View article: Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy
Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy Open
Cone rod dystrophy (CRD) is a macular degeneration disorder characterized by initial cone cell photoreceptor degeneration and subsequently of rod photoreceptors. Mutations in CDHR1, a photoreceptor specific cadherin have been found to be a…
View article: Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy
Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy Open
Cone rod dystrophy (CRD) is a macular degeneration disorder characterized by initial cone cell photoreceptor degeneration and subsequently of rod photoreceptors. Mutations in CDHR1, a photoreceptor specific cadherin have been found to be a…
View article: Author response: Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy
Author response: Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy Open
View article: Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy
Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy Open
Cone rod dystrophy (CRD) is a macular degeneration disorder characterized by initial cone cell photoreceptor degeneration and subsequently of rod photoreceptors. Mutations in CDHR1, a photoreceptor specific cadherin have been found to be a…
View article: E3 ubiquitin ligase-mediated regulation of vertebrate ocular development; new insights into the function of SIAH enzymes
E3 ubiquitin ligase-mediated regulation of vertebrate ocular development; new insights into the function of SIAH enzymes Open
Developmental regulation of the vertebrate visual system has been a focus of investigation for generations as understanding this critical time period has direct implications on our understanding of congenital blinding disease. The majority…
View article: SIAH-MEDIATED UREGULATION OF THE DEVELOPMENT OF THE VISUAL SYSTEM IN ZEBRAFISH (DANIO RERIO)
SIAH-MEDIATED UREGULATION OF THE DEVELOPMENT OF THE VISUAL SYSTEM IN ZEBRAFISH (DANIO RERIO) Open
The eye is a complex organ responsible for vision that which formation depends on several intricate developmental steps. Vision for humans is responsible for the majority of its sensory interactions with the environment. Eye development ca…
View article: Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish
Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish Open
Congenital retinal dystrophies are a major cause of unpreventable and incurable blindness worldwide. Mutations in CDHR1, a retina specific cadherin, are associated with cone-rod dystrophy. The ubiquitin proteasome system (UPS) is responsib…
View article: Hyaloid vasculature and mmp2 activity play a role during optic fissure fusion in zebrafish
Hyaloid vasculature and mmp2 activity play a role during optic fissure fusion in zebrafish Open
View article: Proteasome-mediated regulation of Cdhr1a by Siah1 modulates photoreceptor development and survival in zebrafish
Proteasome-mediated regulation of Cdhr1a by Siah1 modulates photoreceptor development and survival in zebrafish Open
Congenital retinal dystrophies are a major cause of unpreventable and incurable blindness worldwide. Mutations in CDHR1, a retina specific cadherin, are associated with cone-rod dystrophy. The ubiquitin proteasome system (UPS) is responsib…
View article: Pax2a regulates angiogenesis to facilitate mmp2-dependent basement membrane remodeling of the optic fissure
Pax2a regulates angiogenesis to facilitate mmp2-dependent basement membrane remodeling of the optic fissure Open
Vertebrate retinal development requires timely and precise fusion of the optic fissure (OF). Recent studies have suggested hyaloid vasculature to be involved in optic fissure fusion. In order to examine this link, we analyzed OF fusion and…
View article: Ubiquitin-mediated proteasome degradation regulates optic fissure fusion
Ubiquitin-mediated proteasome degradation regulates optic fissure fusion Open
Optic fissure fusion is a critical event during retinal development. Failure of fusion leads to coloboma, a potentially blinding congenital disorder. Pax2a is an essential regulator of optic fissure fusion and the target of numerous morpho…
View article: Siah E3 ubiquitin ligase indirectly regulates Pax2 expression by targeting Nlz2 for proteosomal degradation during retinal morphogenesis.
Siah E3 ubiquitin ligase indirectly regulates Pax2 expression by targeting Nlz2 for proteosomal degradation during retinal morphogenesis. Open
View article: Nitric oxide synthase inhibition impairs muscle regrowth following immobilization
Nitric oxide synthase inhibition impairs muscle regrowth following immobilization Open
View article: Aerobic training attenuates nicotinic acethylcholine receptor changes in the diaphragm muscle during heart failure.
Aerobic training attenuates nicotinic acethylcholine receptor changes in the diaphragm muscle during heart failure. Open
HF alters the mRNA expression of nAChR subunits and the structural characteristics of diaphragm NMJs. In addition, aerobic training did not alter NMJs morphology but attenuated the alterations in heart structure and function and in nAChR s…