Warren D. Reynolds
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View article: Quantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming
Quantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming Open
Hematopoietic stem and progenitor cell (HSPC) transplantation is an essential therapy for hematological conditions, but finer definitions of human HSPC subsets with associated function could enable better tuning of grafts and more routine,…
View article: IKAROS levels are associated with antigen escape in CD19- and CD22-targeted therapies for B-cell malignancies
IKAROS levels are associated with antigen escape in CD19- and CD22-targeted therapies for B-cell malignancies Open
View article: Author Correction: Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
Author Correction: Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas Open
View article: Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas Open
View article: IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell acute lymphoblastic leukemia
IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell acute lymphoblastic leukemia Open
Summary Relapse due to antigen escape is a major cause of treatment failure for patients with B-cell malignancies following targeted immunotherapies, including CD19- and CD22-directed chimeric antigen receptor T (CAR T) cells. To identify …
View article: CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study
CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study Open
View article: Sequential intravenous and intracerebroventricular GD2-CAR T-cell therapy for H3K27M-mutated diffuse midline gliomas
Sequential intravenous and intracerebroventricular GD2-CAR T-cell therapy for H3K27M-mutated diffuse midline gliomas Open
H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the GD2 disialoganglioside and chimeric antigen receptor modified T-cells targeting GD2 (GD2-CART) eradicate DMGs in preclinical models. Arm A of the Phase I trial NCT0419…
View article: DIPG-47. SEQUENTIAL INTRAVENOUS AND INTRACEREBROVENTRICULAR GD2-CAR T-CELL THERAPY FOR H3K27M-MUTATED DIFFUSE MIDLINE GLIOMAS
DIPG-47. SEQUENTIAL INTRAVENOUS AND INTRACEREBROVENTRICULAR GD2-CAR T-CELL THERAPY FOR H3K27M-MUTATED DIFFUSE MIDLINE GLIOMAS Open
BACKGROUND H3K27M-mutant diffuse midline gliomas (DMGs) express uniformly high levels of the GD2 disialoganglioside. In preclinical models, chimeric antigen receptor modified T-cells (CAR T-cells) targeting GD2 robustly regressed orthotopi…
View article: Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors
Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors Open
Summary Hematopoietic stem and progenitor cell (HSPC) transplantation is an essential therapy for hematological conditions, but finer definitions of human HSPC subsets with associated function could enable better tuning of grafts and more …
View article: ATACseq data, processed files and scripts associated with paper 'Quantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming'
ATACseq data, processed files and scripts associated with paper 'Quantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming' Open
These are zipped bam and bed files, processed bulkATAC and scATAC objects and scripts for analysis of ATAC seq data generated from erythrocyte/megakaryocyte progenitors (EMP) and Macrophage/Dendritic cell progenitor (MDP) populations isola…
View article: Fcs files used in "Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors"
Fcs files used in "Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors" Open
Mass cytometry data from the manuscript, "Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors". This repository contains singlet-gated, viable, CD45+, batch-corrected cells from t…
View article: Fcs files used in "Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors"
Fcs files used in "Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors" Open
Mass cytometry data from the manuscript, "Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors". This repository contains singlet-gated, viable, CD45+, batch-corrected cells from t…
View article: S230: CD22 CAR T CELL THERAPY IS SAFE AND EFFECTIVE IN PATIENTS WITH LARGE B CELL LYMPHOMA WHO HAVE RELAPSED AFTER CD19 CAR T CELL THERAPY.
S230: CD22 CAR T CELL THERAPY IS SAFE AND EFFECTIVE IN PATIENTS WITH LARGE B CELL LYMPHOMA WHO HAVE RELAPSED AFTER CD19 CAR T CELL THERAPY. Open
Background: Patients with relapsed/refractory large B-cell lymphoma (LBCL) who progress after CD19 CAR T-cell therapy (CAR19) have poor outcomes. CD22 is expressed on the majority of B-cell lymphomas. Here, we report on the evaluation of a…
View article: Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy
Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy Open
View article: DIPG-15. Major tumor regressions in H3K27M-mutated diffuse midline glioma (DMG) following sequential intravenous (IV) and intracerebroventricular (ICV) delivery of GD2-CAR T-cells
DIPG-15. Major tumor regressions in H3K27M-mutated diffuse midline glioma (DMG) following sequential intravenous (IV) and intracerebroventricular (ICV) delivery of GD2-CAR T-cells Open
BACKGROUND: H3K27M-mutated DMGs express high levels of the disialoganglioside GD2 and GD2-CAR T-cells (GD2-CART) regress DMG in preclinical models. METHODS: NCT04196413 is a 3 + 3 Phase I dose escalation trial testing GD2-CART in patients …
View article: Integrating transcription-factor abundance with chromatin accessibility in human erythroid lineage commitment
Integrating transcription-factor abundance with chromatin accessibility in human erythroid lineage commitment Open
Master transcription factors (TFs) directly regulate present and future cell states by binding DNA regulatory elements and driving gene-expression programs. Their abundance influences epigenetic priming to different cell fates at the chrom…
View article: GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas Open
Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system 1 . We have previously shown that the disialoganglioside GD2 is highly …
View article: Multi-Omic Single Cell Identification of Lin- CD34- Natural Killer Cell Progenitors in Human Hematopoiesis
Multi-Omic Single Cell Identification of Lin- CD34- Natural Killer Cell Progenitors in Human Hematopoiesis Open
View article: Chromatin accessibility associates with protein-RNA correlation in human cancer
Chromatin accessibility associates with protein-RNA correlation in human cancer Open
View article: CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial Open
Despite impressive progress, more than 50% of patients treated with CD19-targeting chimeric antigen receptor T cells (CAR19) experience progressive disease. Ten of 16 patients with large B cell lymphoma (LBCL) with progressive disease afte…
View article: Integrating transcription factor abundance with chromatin accessibility in human erythroid lineage commitment
Integrating transcription factor abundance with chromatin accessibility in human erythroid lineage commitment Open
We present InTAC-seq, a method for simultaneous quantification of genome-wide open chromatin and intracellular protein abundance in fixed cells. Using InTAC we directly observe variation in chromatin accessibility and transcription factor …
View article: CD22-directed CAR T-cell therapy induces complete remissions in CD19-directed CAR–refractory large B-cell lymphoma
CD22-directed CAR T-cell therapy induces complete remissions in CD19-directed CAR–refractory large B-cell lymphoma Open
The prognosis of patients with large B-cell lymphoma (LBCL) that progresses after treatment with chimeric antigen receptor (CAR) T-cell therapy targeting CD19 (CAR19) is poor. We report on the first 3 consecutive patients with autologous C…
View article: Characterization of the Human KCNQ1 Voltage Sensing Domain (VSD) in Lipodisq Nanoparticles for Electron Paramagnetic Resonance (EPR) Spectroscopic Studies of Membrane Proteins
Characterization of the Human KCNQ1 Voltage Sensing Domain (VSD) in Lipodisq Nanoparticles for Electron Paramagnetic Resonance (EPR) Spectroscopic Studies of Membrane Proteins Open
Membrane proteins are responsible for conducting essential biological functions that are necessary for the survival of living organisms. In spite of their physiological importance, limited structural information is currently available as a…
View article: Studying Conformation of the Voltage-Sensor Domain (VSD) of the Human KCNQ1 Potassium Ion Channel in Proteoliposomes using EPR Spectroscopy
Studying Conformation of the Voltage-Sensor Domain (VSD) of the Human KCNQ1 Potassium Ion Channel in Proteoliposomes using EPR Spectroscopy Open