Mark McLaughlin
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View article: Cover Feature: Five‐Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade (Chem. Eur. J. 62/2020)
Cover Feature: Five‐Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade (Chem. Eur. J. 62/2020) Open
A ball-and-stick Houk-style view of islatravir, the target of the total synthesis described in this work, is depicted in the cover image. Islatravir is on top of a “caged” Human Immunodeficiency Virus to indicate that the molecule is an HI…
View article: Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin
Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin Open
A highly efficient asymmetric synthesis of the key tetrahydropyranol intermediate of DPP-4 inhibitor omarigliptin (1) is described. The successful development of a protecting-group- and precious-metal-free synthesis was achieved via the di…
View article: CCDC 1499865: Experimental Crystal Structure Determination
CCDC 1499865: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1499851: Experimental Crystal Structure Determination
CCDC 1499851: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1444069: Experimental Crystal Structure Determination
CCDC 1444069: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Some Items of Interest to Process R&D Chemists and Engineers
Some Items of Interest to Process R&D Chemists and Engineers Open
ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersMark McLaughlin, Robert Ely, Antonio Ramirez, Paul Richardson, Joseck Muhuhi, Andrei Zlot…
View article: CCDC 1419649: Experimental Crystal Structure Determination
CCDC 1419649: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …