Warren P. Porter
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View article: Sex‐specific trade‐offs influence thermoregulation under climate change
Sex‐specific trade‐offs influence thermoregulation under climate change Open
Increasingly, climate change is pushing species to the limits of their thermal tolerance, with cascading effects across ecosystems. Animals use behavior to prevent these harmful physiological states, but their need and ability to do so var…
View article: Metabolic skinflint or spendthrift? Insights into ground sloth integument and thermophysiology revealed by biophysical modeling and clumped isotope paleothermometry
Metabolic skinflint or spendthrift? Insights into ground sloth integument and thermophysiology revealed by biophysical modeling and clumped isotope paleothermometry Open
Remains of megatheres have been known since the 18th -century and were among the first megafaunal vertebrates to be studied. While several examples of preserved integument show a thick coverage of fur for smaller ground sloths living in co…
View article: Synergized resmethrin and corticosterone alter the chicken's response to west nile virus
Synergized resmethrin and corticosterone alter the chicken's response to west nile virus Open
Debate concerning arbovirus control strategies remains contentious because concern regarding the relative risk of viral infection and environmental toxicant exposure is high but inadequately characterized. Taking this into account, mosquit…
View article: Looking to the Future in Managing a Dairy Production System: A Perspective
Looking to the Future in Managing a Dairy Production System: A Perspective Open
Future directions in the cattle industry will be driven by consumer demand for higher quality foods and production methods involving animal health and comfort in changing climates, diet quality, management practices and disease reduction
View article: Climate Spaces and Cliffs: A Novel Bovine Thermodynamic and Mass Balances Model
Climate Spaces and Cliffs: A Novel Bovine Thermodynamic and Mass Balances Model Open
The effects of climate change on animals are typically viewed in terms of survivability and wellbeing. In this study, we broaden that purview to include climate impacts on reproductive capability. There are not only climate spaces for dail…
View article: Data from Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue
Data from Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue Open
Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity, whereas single-cell imaging method…
View article: Blaesius_Manuscript_MCR_Aug26_2016_Supplemental tables and figures from Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue
Blaesius_Manuscript_MCR_Aug26_2016_Supplemental tables and figures from Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue Open
Cell sorting strategy, Pathway maps for differentially expressed genes, Differentially expressed surface markers, AXL gene set used in analysis. Figure S1: Staining and gating strategy of flow cytometry analysis. Figure S2: Sorting strateg…
View article: Blaesius_Manuscript_MCR_Aug26_2016_Supplemental tables and figures from Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue
Blaesius_Manuscript_MCR_Aug26_2016_Supplemental tables and figures from Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue Open
Cell sorting strategy, Pathway maps for differentially expressed genes, Differentially expressed surface markers, AXL gene set used in analysis. Figure S1: Staining and gating strategy of flow cytometry analysis. Figure S2: Sorting strateg…
View article: Data from Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue
Data from Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue Open
Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity, whereas single-cell imaging method…
View article: Mechanistic Thermal Modeling of Late Triassic Terrestrial Amniotes Predicts Biogeographic Distribution
Mechanistic Thermal Modeling of Late Triassic Terrestrial Amniotes Predicts Biogeographic Distribution Open
The biogeography of terrestrial amniotes is controlled by historical contingency interacting with paleoclimate, morphology and physiological constraints to dispersal. Thermal tolerance is the intersection between organismal requirements an…
View article: NicheMapR – an R package for biophysical modelling: the endotherm model
NicheMapR – an R package for biophysical modelling: the endotherm model Open
Endothermic organisms typically maintain high and relatively constant body temperatures in the face of environmental variation by regulating their metabolic and water loss rates in conjunction with behavioural and postural adjustments. A m…
View article: Meeting Paris agreement objectives will temper seabird winter distribution shifts in the North Atlantic Ocean
Meeting Paris agreement objectives will temper seabird winter distribution shifts in the North Atlantic Ocean Open
We explored the implications of reaching the Paris Agreement Objective of limiting global warming to <2°C for the future winter distribution of the North Atlantic seabird community. We predicted and quantified current and future winter hab…
View article: Predictions of Disease Risk in Space and Time Based on the Thermal Physiology of an Amphibian Host-Pathogen Interaction
Predictions of Disease Risk in Space and Time Based on the Thermal Physiology of an Amphibian Host-Pathogen Interaction Open
Emerging infectious diseases have been responsible for declines and extinctions in a growing number of species. Predicting disease variables like infection prevalence and mortality and how they vary in space and time will be critical to un…
View article: Infrared thermography cannot be used to approximate core body temperature in wild primates
Infrared thermography cannot be used to approximate core body temperature in wild primates Open
Understanding the physiological processes that underpin primate performance is key if we are to assess how a primate might respond when navigating new and changing environments. Given the connection between an animal’s ability to thermoreg…
View article: Future winters present a complex energetic landscape of decreased costs and reduced risk for a freeze‐tolerant amphibian, the Wood Frog (<i>Lithobates sylvaticus</i>)
Future winters present a complex energetic landscape of decreased costs and reduced risk for a freeze‐tolerant amphibian, the Wood Frog (<i>Lithobates sylvaticus</i>) Open
Winter climate warming is rapidly leading to changes in snow depth and soil temperatures across mid‐ and high‐latitude ecosystems, with important implications for survival and distribution of species that overwinter beneath the snow. Amphi…
View article: Modeling Dragons: Using linked mechanistic physiological and microclimate models to explore environmental, physiological, and morphological constraints on the early evolution of dinosaurs
Modeling Dragons: Using linked mechanistic physiological and microclimate models to explore environmental, physiological, and morphological constraints on the early evolution of dinosaurs Open
We employed the widely-tested biophysiological modeling software, Niche Mapper™ to investigate the metabolic function of the Late Triassic dinosaurs Plateosaurus and Coelophysis during global greenhouse conditions. We tested a variety of a…
View article: Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue
Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue Open
Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment (TME). Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity while single cell imaging met…
View article: Supporting data: Infrared thermography cannot be used to approximate core body temperature in wild primates
Supporting data: Infrared thermography cannot be used to approximate core body temperature in wild primates Open
Core body and surface temperatures of wild vervet monkeys
View article: Climate change could overturn bird migration: Transarctic flights and high-latitude residency in a sea ice free Arctic
Climate change could overturn bird migration: Transarctic flights and high-latitude residency in a sea ice free Arctic Open
Climate models predict that by 2050 the Arctic Ocean will be sea ice free each summer. Removing this barrier between the Atlantic and the Pacific will modify a wide range of ecological processes, including bird migration. Using published i…
View article: NicheMapR – an R package for biophysical modelling: the ectotherm and Dynamic Energy Budget models
NicheMapR – an R package for biophysical modelling: the ectotherm and Dynamic Energy Budget models Open
Mechanistic niche models characterise the fundamental niche of an organism by determining thermodynamic constraints on its heat, water and nutritional budget, and the consequences of this for growth, development and reproduction. They can …
View article: Modeling Dragons: Using linked mechanistic physiological and microclimate models to explore environmental, physiological, and morphological constraints on the early evolution of dinosaurs
Modeling Dragons: Using linked mechanistic physiological and microclimate models to explore environmental, physiological, and morphological constraints on the early evolution of dinosaurs Open
We employed the widely-tested biophysiological modeling software, Niche Mapper™ to investigate the metabolic function of Late Triassic dinosaurs Plateosaurus and Coelophysis during global greenhouse conditions. We tested them under a varie…
View article: Abstract 4710: Surface protein marker and single cell gene expression profiling of individual tumor cells dissociated from small cell lung cancer pdx mouse models can be correlated with<i>in vivo</i>sensitivity to the p70S6K/AKT1/3 inhibitor M2698
Abstract 4710: Surface protein marker and single cell gene expression profiling of individual tumor cells dissociated from small cell lung cancer pdx mouse models can be correlated with<i>in vivo</i>sensitivity to the p70S6K/AKT1/3 inhibitor M2698 Open
Small Cell Lung Cancer (SCLC) is characterized by rapid tumor growth and currently, there are few therapeutic options or predictive biomarkers. Patient derived xenograft (PDX) models are capable of recapitulating solid tumor growth includi…
View article: Modeling the distribution of niche space and risk for a freeze‐tolerant ectotherm, <i>Lithobates sylvaticus</i>
Modeling the distribution of niche space and risk for a freeze‐tolerant ectotherm, <i>Lithobates sylvaticus</i> Open
Many animals depend on stable below‐the‐snow (subnivium) conditions to survive winter in seasonally cold regions. Freeze‐tolerant ectotherms may experience increased ice content and/or energy expenditure in suboptimal subnivium conditions,…
View article: Shifts in metabolic fuel use coincide with maximal rates of ventilation and body surface rewarming in an arousing hibernator
Shifts in metabolic fuel use coincide with maximal rates of ventilation and body surface rewarming in an arousing hibernator Open
It is well established that hibernating mammals rely predominantly on lipid stores to fuel metabolism throughout the hibernation season. However, it is unclear if other endogenous fuels contribute to the rapid, ~400-fold increase in metabo…
View article: Issue Information
Issue Information Open
Douglas-fi r tree seedling that established in a controlled-environment experiment