Marian Warsame
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View article: Efficacy and Safety of Artemether-Lumefantrine Against Uncomplicated Falciparum Malaria Infection in Tanzania, 2022: A Single-Arm Clinical Trial
Efficacy and Safety of Artemether-Lumefantrine Against Uncomplicated Falciparum Malaria Infection in Tanzania, 2022: A Single-Arm Clinical Trial Open
Background Artemether-lumefantrine (AL) is the first-line antimalarial drug for the treatment of uncomplicated malaria in Tanzania. The World Health Organization (WHO) recommends regular efficacy monitoring of antimalarial drugs to inform …
View article: Evidence of artemisinin partial resistance in northwestern Tanzania: clinical and molecular markers of resistance
Evidence of artemisinin partial resistance in northwestern Tanzania: clinical and molecular markers of resistance Open
View article: Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2019
Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2019 Open
View article: Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2018
Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2018 Open
View article: Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021
Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021 Open
View article: Microsatellites reveal high polymorphism and high potential for use in anti-malarial efficacy studies in areas with different transmission intensities in mainland Tanzania
Microsatellites reveal high polymorphism and high potential for use in anti-malarial efficacy studies in areas with different transmission intensities in mainland Tanzania Open
Background Tanzania is currently implementing therapeutic efficacy studies (TES) in areas of varying malaria transmission intensities as per the World Health Organization (WHO) recommendations. In TES, distinguishing reinfection from recru…
View article: Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021
Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021 Open
Background Therapeutic efficacy studies (TESs) and detection of molecular markers of drug resistance are recommended by the World Health Organization (WHO) to monitor the efficacy of artemisinin-based combination therapy (ACT). This study …
View article: Evidence of artemisinin partial resistance in North-western Tanzania: clinical and drug resistance markers study
Evidence of artemisinin partial resistance in North-western Tanzania: clinical and drug resistance markers study Open
Background Artemisinin-based combination therapies (ACTs) are the recommended antimalarial drugs for the treatment of uncomplicated malaria. The recent emergence of artemisinin partial resistance (ART-R) in Rwanda, Uganda and Eritrea is of…
View article: Trends of<i>Plasmodium falciparum</i>molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021
Trends of<i>Plasmodium falciparum</i>molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021 Open
Background Therapeutic efficacy studies (TESs) and detection of molecular markers of drug resistance are recommended by the World Health Organization (WHO) to monitor the efficacy of artemis inin combination therapy (ACT). This study asses…
View article: Efficacy and Safety of Artemether-lumefantrine for the Treatment of Uncomplicated Falciparum Malaria in Mainland Tanzania, 2019
Efficacy and Safety of Artemether-lumefantrine for the Treatment of Uncomplicated Falciparum Malaria in Mainland Tanzania, 2019 Open
Background Artemisinin-based combination therapies (ACTs) have been a major contributor to the substantial reductions in global malaria morbidity and mortality over the last decade. In Tanzania, artemether-lumefantrine (AL) was introduced …
View article: Evidence of Artemisinin Partial Resistance in North-Western Tanzania: Clinical and Drug Resistance Markers Study
Evidence of Artemisinin Partial Resistance in North-Western Tanzania: Clinical and Drug Resistance Markers Study Open
View article: Promoting research for the fragile Somali health system –
Promoting research for the fragile Somali health system – Open
A 3-day conference was held in Garowe from the 30th of January to the 1st of February 2022 under the leadership of the Somali National Institute of Health to strengthen the foundation of health research in the country by promoting strategi…
View article: Microsatellites reveal high polymorphism and high potential for use in antimalarial efficacy studies in areas with different transmission intensities in mainland Tanzania
Microsatellites reveal high polymorphism and high potential for use in antimalarial efficacy studies in areas with different transmission intensities in mainland Tanzania Open
Background Tanzania is currently implementing therapeutic efficacy studies (TES) in areas of varying malaria transmission intensities as per the World Health Organization’s (WHO) recommendations. In TES, distinguishing reinfection from rec…
View article: Health research prioritization in Somalia: setting the agenda for context specific knowledge to advance universal health coverage
Health research prioritization in Somalia: setting the agenda for context specific knowledge to advance universal health coverage Open
Introduction Despite recognition that health research is an imperative to progress toward universal health coverage, resources for health research are limited. Yet, especially in sub-Saharan Africa, more than 85% of the resources available…
View article: Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2018
Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2018 Open
Background : Use of artemisinin combination therapy (ACT) is recommended by the World Health Organization (WHO) for the treatment of uncomplicated falciparum malaria. Artemether-lumefantrine (AL) is the most widely adopted first-line ACT f…
View article: Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea
Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea Open
The emergence and spread of P. falciparum lineages with both Pfkelch13-mediated partial resistance to artemisinin and deletions in hrp2 and hrp3 in Eritrea threaten to compromise regional malaria control and eli…
View article: Antimalarial drug efficacy and resistance in malaria‐endemic countries in <scp>HANMAT‐PIAM_net</scp> countries of the Eastern Mediterranean Region 2016–2020: Clinical and genetic studies
Antimalarial drug efficacy and resistance in malaria‐endemic countries in <span>HANMAT‐PIAM_net</span> countries of the Eastern Mediterranean Region 2016–2020: Clinical and genetic studies Open
Introduction The World Health Organization recommends regular monitoring of the efficacy of nationally recommended antimalarial drugs. We present the results of studies on the efficacy of recommended antimalarials and molecular markers of …
View article: Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Chad: clinical and genetic surveillance
Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Chad: clinical and genetic surveillance Open
View article: Stopping prereferral rectal artesunate — a grave error
Stopping prereferral rectal artesunate — a grave error Open
View article: Survey and Analysis of Chemoprophylaxis Policies for Domestic Travel in Malaria-Endemic Countries
Survey and Analysis of Chemoprophylaxis Policies for Domestic Travel in Malaria-Endemic Countries Open
The prevention of malaria in travelers with the use of antimalarials often occurs in connection with international travel to areas of significant risk of infection. Although these travelers sometimes cause outbreaks in their malaria-free h…
View article: Artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers
Artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers Open
View article: Additional file 1 of Artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers
Additional file 1 of Artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers Open
Additional file 1. Liberia genotyping raw data.
View article: Current guidelines for malaria treatment in Somalia: evidence-based recommendations
Current guidelines for malaria treatment in Somalia: evidence-based recommendations Open
Case management – rapid diagnosis and prompt administration of artemisinin-based combination therapy (ACT) – is a fundamental pillar of recommended malaria interventions in Somalia. Unfortunately, the emergence and spread of drug resistant…
View article: Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness Open
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13- propeller genotyping confirms the emergence of the…
View article: Author response: Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
Author response: Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The emergence of mutant K13-mediated artem…
View article: Therapeutic efficacy of artesunate-amodiaquine and artemether-lumefantrine and polymorphism in Plasmodium falciparum kelch13-propeller gene in Equatorial Guinea
Therapeutic efficacy of artesunate-amodiaquine and artemether-lumefantrine and polymorphism in Plasmodium falciparum kelch13-propeller gene in Equatorial Guinea Open
View article: Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda
Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda Open
View article: <i>P. falciparum</i>K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites
<i>P. falciparum</i>K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites Open
The emergence of artemisinin (ART) resistance in Plasmodium falciparum parasites, driven by K13 mutations, has led to widespread antimalarial treatment failure in Southeast Asia. In Africa, our genotyping of 3,299 isolates confirms the eme…
View article: <i>Plasmodium falciparum</i> K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites
<i>Plasmodium falciparum</i> K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites Open
The emergence of artemisinin (ART) resistance in Plasmodium falciparum parasites has led to increasing rates of treatment failure with first-line ART-based combination therapies (ACTs) in Southeast Asia. In this region, select mutations in…
View article: Describing the current status of <i>Plasmodium falciparum</i> population structure and drug resistance within mainland Tanzania using molecular inversion probes
Describing the current status of <i>Plasmodium falciparum</i> population structure and drug resistance within mainland Tanzania using molecular inversion probes Open
High‐throughput Plasmodium genomic data is increasingly useful in assessing prevalence of clinically important mutations and malaria transmission patterns. Understanding parasite diversity is important for identification of specific human …