Wasfi Alrawashdeh
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View article: Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver
Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver Open
Our spatial multi-omics approach suggests cell type-specific mechanisms of fibrogenesis involving sphingolipid metabolism. Importantly, sphingolipid metabolic pathways are modifiable targets, which may have potential as an anti-fibrotic th…
View article: Pharmacological manipulation of liver fibrosis progression using novel <scp>HDAC</scp>6 inhibitors
Pharmacological manipulation of liver fibrosis progression using novel <span>HDAC</span>6 inhibitors Open
Chronic liver injury characterized by unresolved hepatitis leads to fibrosis, potentially progressing to cirrhosis and hepatocellular carcinoma. Effective treatments for halting or reversing liver fibrosis are currently lacking. This study…
View article: 184 Experience of Hypothermic Oxygenated Machine Perfusion for Liver Transplantation and Ex-vivo Liver Resection-largest reported single centre experience in the UK
184 Experience of Hypothermic Oxygenated Machine Perfusion for Liver Transplantation and Ex-vivo Liver Resection-largest reported single centre experience in the UK Open
Background Hypothermic oxygenated machine perfusion (HOPE) is being increasingly utilised in deceased donor liver transplantation to recondition expanded-criteria livers prior to transplantation as well as reducing night time liver transpl…
View article: UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis
UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis Open
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in most types of chronic liver disease. At the cellular level, liver fibrosis is associated with the activation of hepatic stellate cells (HSCs) whic…
View article: Supplementary Figure 3 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 3 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Diagnostic performance of urine biomarkers in discriminating pancreatic adenocarcinoma all stages (A-C) and stage I-II (D-F) from chronic pancreatitis patients. A, ROC curves of PDAC (n=143) versus CP (n=62) patients for individual urine b…
View article: Supplementary Figure 4 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 4 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Exploratory comparison of plasma CA19.9 and the urine biomarker panel in discriminating early pancreatic adenocarcinoma from chronic pancreatitis patients. A, ROC curves of the biomarker panel with corresponding plasma CA19.9 alone and in …
View article: Supplementary Figure 6 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 6 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Expression of the protein biomarkers in pancreatic cancer tissues. A, Immunohistochemical analysis of REG1A: i) REG1A in poorly differentiated PDAC, ii) luminal REG1A in malignant glands. B, TFF1: i) heterogenous expression in cancer,, ii)…
View article: Supplementary Figure 1 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 1 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Urine proteome analysis. A, schematic outline of the study. B, classification of total identified proteins according to sub-cellular localisation and C, functional activity determined by Ingenuity Pathway Analysis. H: healthy, CP: chronic …
View article: Supplementary Figure 2 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 2 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Correlation of the three urinary biomarkers and plasma CA19.9 (CA19.9p). A, Correlation plots (Navy blue: Healthy; Turquoise: chronic pancreatitis (CP); Purple: pancreatic adenocarcinoma (PDAC). B, Pearson correlation coefficients and corr…
View article: Supplementary Figure 3 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 3 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Diagnostic performance of urine biomarkers in discriminating pancreatic adenocarcinoma all stages (A-C) and stage I-II (D-F) from chronic pancreatitis patients. A, ROC curves of PDAC (n=143) versus CP (n=62) patients for individual urine b…
View article: Supplementary Table 1 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Table 1 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Expression of non-redundant proteins identified by GeLC-MS/MS from males and females in healthy controls, chronic pancreatitis and pancreatic adenocarcinoma patients.
View article: Supplementary Figure 5 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 5 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Urine biomarker concentrations in different tumours. Scatter dot plots of urine LYVE1, REG1A and plasma CA19.9 in different hepatobiliary pathologies and early stages of pancreatic adenocarcinoma (I-IIA, n=16) and I-II (n=71). The level of…
View article: Supplementary Figure Legends from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure Legends from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Supplementary Figure Legends from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
View article: Data from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Data from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Purpose: Noninvasive biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC) are currently not available. Here, we aimed to identify a set of urine proteins able to distinguish patients with early-stage PDAC from h…
View article: Supplementary Figure 5 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 5 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Urine biomarker concentrations in different tumours. Scatter dot plots of urine LYVE1, REG1A and plasma CA19.9 in different hepatobiliary pathologies and early stages of pancreatic adenocarcinoma (I-IIA, n=16) and I-II (n=71). The level of…
View article: Supplementary Figure 1 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 1 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Urine proteome analysis. A, schematic outline of the study. B, classification of total identified proteins according to sub-cellular localisation and C, functional activity determined by Ingenuity Pathway Analysis. H: healthy, CP: chronic …
View article: Data from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Data from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Purpose: Noninvasive biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC) are currently not available. Here, we aimed to identify a set of urine proteins able to distinguish patients with early-stage PDAC from h…
View article: Supplementary Figure Legends from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure Legends from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Supplementary Figure Legends from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
View article: Supplementary Figure 4 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 4 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Exploratory comparison of plasma CA19.9 and the urine biomarker panel in discriminating early pancreatic adenocarcinoma from chronic pancreatitis patients. A, ROC curves of the biomarker panel with corresponding plasma CA19.9 alone and in …
View article: Supplementary Figure 2 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 2 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Correlation of the three urinary biomarkers and plasma CA19.9 (CA19.9p). A, Correlation plots (Navy blue: Healthy; Turquoise: chronic pancreatitis (CP); Purple: pancreatic adenocarcinoma (PDAC). B, Pearson correlation coefficients and corr…
View article: Supplementary Figure 6 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Figure 6 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Expression of the protein biomarkers in pancreatic cancer tissues. A, Immunohistochemical analysis of REG1A: i) REG1A in poorly differentiated PDAC, ii) luminal REG1A in malignant glands. B, TFF1: i) heterogenous expression in cancer,, ii)…
View article: Supplementary Table 1 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma
Supplementary Table 1 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma Open
Expression of non-redundant proteins identified by GeLC-MS/MS from males and females in healthy controls, chronic pancreatitis and pancreatic adenocarcinoma patients.
View article: T2a gallbladder cancers have better overall survival and lower recurrence than T2b: a systematic review and meta-analysis
T2a gallbladder cancers have better overall survival and lower recurrence than T2b: a systematic review and meta-analysis Open
View article: Future directions in preclinical and translational cancer neuroscience research
Future directions in preclinical and translational cancer neuroscience research Open
View article: Development and Validation of a Comprehensive Model to Estimate Early Allograft Failure Among Patients Requiring Early Liver Retransplant
Development and Validation of a Comprehensive Model to Estimate Early Allograft Failure Among Patients Requiring Early Liver Retransplant Open
This study found that the developed EASE score reliably estimated EAF risk. Knowledge of contributing factors may help clinicians to mitigate risk factors and guide them through the challenging clinical decision to allocate patients to ear…
View article: Clinically Actionable Strategies for Studying Neural Influences in Cancer
Clinically Actionable Strategies for Studying Neural Influences in Cancer Open
View article: A systematic review and network meta-analysis of phase III randomised controlled trials for adjuvant therapy following resection of pancreatic ductal adenocarcinoma (PDAC)
A systematic review and network meta-analysis of phase III randomised controlled trials for adjuvant therapy following resection of pancreatic ductal adenocarcinoma (PDAC) Open
View article: Perineural invasion in pancreatic cancer: proteomic analysis and <i>in vitro</i> modelling
Perineural invasion in pancreatic cancer: proteomic analysis and <i>in vitro</i> modelling Open
Perineural invasion ( PNI ) is a common and characteristic feature of pancreatic ductal adenocarcinoma ( PDAC ) that is associated with poor prognosis, tumor recurrence, and generation of pain. However, the molecular alterations in cancer …
View article: ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation
ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation Open
View article: Use of short-term steroids in the prophylaxis of atrial fibrillation after cardiac surgery
Use of short-term steroids in the prophylaxis of atrial fibrillation after cardiac surgery Open
Prophylactic short-term use of steroids both intraoperatively and postoperatively proved to be safe and effective in reducing the incidence of postoperative AF in patients undergoing CABG alone or combined with valve surgery.