Wasif Ali Khan
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View article: Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis
Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis Open
Background The antirelapse efficacy of primaquine is related to the total dose administered, whereas the risks of haemolysis and gastrointestinal intolerance are associated with the daily dose administered. National Malaria Control Program…
View article: Association of Timing and Duration of Moderate-to-Vigorous Physical Activity with Cognitive Function and Brain Aging: A Population-Based Study Using the UK Biobank
Association of Timing and Duration of Moderate-to-Vigorous Physical Activity with Cognitive Function and Brain Aging: A Population-Based Study Using the UK Biobank Open
Physical activity is a modifiable lifestyle factor with potential to support cognitive resilience. However, the association of moderate-to-vigorous physical activity (MVPA) intensity, and timing, with cognitive function and region-specific…
View article: Enterovirus 71 seropositivity among children and adolescents in Bangladesh
Enterovirus 71 seropositivity among children and adolescents in Bangladesh Open
View article: Assessment of Complications Associated with Metallic Plate Removal in Maxillofacial Surgical Patients
Assessment of Complications Associated with Metallic Plate Removal in Maxillofacial Surgical Patients Open
Background: Metallic hardware is widely used in oral and maxillofacial surgery for skeletal stabilization, yet its long-term retention can lead to complications such as infection, discomfort, and plate exposure. Despite the clinical signif…
View article: Awareness of Tuberculosis Among General Population of Riyadh, Kingdom of Saudi Arabia: A Cross-Sectional Study
Awareness of Tuberculosis Among General Population of Riyadh, Kingdom of Saudi Arabia: A Cross-Sectional Study Open
Among the 392 participants, 94.6% had heard of tuberculosis, with 85.2% aware that tuberculosis affects the lungs. However, knowledge about tuberculosis transmission and its bacterial cause was lacking in 14.5% and 31.1% of respondents, re…
View article: Clinical validation of peripheral blood mononuclear cell DNA methylation markers for accurate early detection of hepatocellular carcinoma in Asian patients
Clinical validation of peripheral blood mononuclear cell DNA methylation markers for accurate early detection of hepatocellular carcinoma in Asian patients Open
Our study confirms that combining gene methylation profiles with established diagnostic markers substantially improves the sensitivity of detecting early-stage HCC. This integrated diagnostic approach holds promise for advancing non-invasi…
View article: POPULIST POLITICS IN PAKISTAN: A CASE STUDY OF PAKISTAN THREEK -E- INSAF (PTI) FROM 2018-2023
POPULIST POLITICS IN PAKISTAN: A CASE STUDY OF PAKISTAN THREEK -E- INSAF (PTI) FROM 2018-2023 Open
Populism, although not a new political ideology, has witnessed a significant resurgence since the late 20th century. Emerging initially among Southern sharecroppers and tenant farmers in the United States during the 1880s, populism has sin…
View article: The Impact of Economic Fluctuations on Project Management Practices in Large-Scale Construction Projects
The Impact of Economic Fluctuations on Project Management Practices in Large-Scale Construction Projects Open
This study investigates the influence of economic changes on management practices in Pakistan, focusing on key areas, including budgeting, cost management, monitoring, project planning, resource allocation, procurement, and risk management…
View article: Safety and efficacy of primaquine in patients with <i>Plasmodium vivax</i> malaria from South Asia: a systematic review and individual patient data meta-analysis
Safety and efficacy of primaquine in patients with <i>Plasmodium vivax</i> malaria from South Asia: a systematic review and individual patient data meta-analysis Open
Background The optimal dosing of primaquine to prevent relapsing Plasmodium vivax malaria in South Asia remains unclear. We investigated the efficacy and safety of different primaquine regimens to prevent P. vivax relapse. Methods A system…
View article: Adherence to Anti-Malarial Treatment in Malaria Endemic Areas of Bangladesh
Adherence to Anti-Malarial Treatment in Malaria Endemic Areas of Bangladesh Open
Ensuring adherence to antimalarial treatment is crucial for achieving a radical cure and elimination of malaria, especially in hard-to-reach areas. We conducted this study to assess the current scenario of drug adherence in four endemic su…
View article: Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis Open
Background Imperfect adherence is a major barrier to effective primaquine radical cure of Plasmodium vivax . This study investigated the effect of reduced adherence on the risk of P. vivax recurrence. Methods Efficacy studies of patients w…
View article: Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis
Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis Open
Australian National Health and Medical Research Council, Bill & Melinda Gates Foundation, and Medicines for Malaria Venture.
View article: Is this pill an antibiotic or a painkiller? Improving the identification of oral antibiotics for better use
Is this pill an antibiotic or a painkiller? Improving the identification of oral antibiotics for better use Open
In this Viewpoint, we discuss how the identification of oral antibiotics and their distinction from other commonly used medicines can be challenging for consumers, suppliers, and health-care professionals. There is a large variation in the…
View article: A high-throughput test enables specific detection of hepatocellular carcinoma
A high-throughput test enables specific detection of hepatocellular carcinoma Open
View article: Composition of Anopheles species and bionomic characteristics over the peak malaria transmission season in Bandarban, Bangladesh
Composition of Anopheles species and bionomic characteristics over the peak malaria transmission season in Bandarban, Bangladesh Open
View article: Supplementary Table 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Table 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 71KB, Supplementary Table S2. A list of kinases whose phosphorylation was examined in SkHep1 liver cancer cells after RASAL2, NENF or combined RASAL2 and NENF depletion. The level of phosphorylation is expressed as a percentage …
View article: Data from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Data from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
Purpose: We utilized whole-genome mapping of promoters that are activated by DNA hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel targets for anticancer therapeutics. We provide a proof of princi…
View article: Supplementary Figure 8 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 8 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 685KB, Supplementary Figure S8. Expression of different RASAL2 transcript variants in liver cancer cells and normal hepatocytes. (A,B) Expression of RASAL2 as measured by QPCR using primers specific to transcript variant 1 and s…
View article: Supplementary Materials and Methods, Figure Legends, Table Legends from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Materials and Methods, Figure Legends, Table Legends from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 116KB
View article: Supplementary Materials and Methods, Figure Legends, Table Legends from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Materials and Methods, Figure Legends, Table Legends from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 116KB
View article: Supplementary Figure 4 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 4 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 651KB, Supplementary Figure S4. Expression of RASAL2 and NENF on the protein level as determined by western blot using anti-RASAL2 (Bethyl Laboratories Inc., A302-109A) or anti-NENF (Abcam, ab74474) antibody at 1:1000 and 1:500 …
View article: Supplementary Figure 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 492KB, Supplementary Figure S2. (A) Effect of 5-azaCdR at 1.0 microM concentration on non-transformed NorHep cell growth throughout 20 day-treatment. NorHep cells were seeded at a density of 3 x 105 per a 10-cm tissue culture di…
View article: Supplementary Figure 4 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 4 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 651KB, Supplementary Figure S4. Expression of RASAL2 and NENF on the protein level as determined by western blot using anti-RASAL2 (Bethyl Laboratories Inc., A302-109A) or anti-NENF (Abcam, ab74474) antibody at 1:1000 and 1:500 …
View article: Data from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Data from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
Purpose: We utilized whole-genome mapping of promoters that are activated by DNA hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel targets for anticancer therapeutics. We provide a proof of princi…
View article: Supplementary Figure 1 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 1 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 961KB, Supplementary Figure S1. (A,B) Extensive methylation analysis of RASAL2 (A) and NENF (B) promoters in cells treated with 5-azaCdR, different cell lines and patients. Average methylation state of CpG sites was determined b…
View article: Supplementary Table 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Table 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 71KB, Supplementary Table S2. A list of kinases whose phosphorylation was examined in SkHep1 liver cancer cells after RASAL2, NENF or combined RASAL2 and NENF depletion. The level of phosphorylation is expressed as a percentage …
View article: Supplementary Figure 6 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 6 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 701KB, Supplementary Figure S6. (A) 1) Expression of the depleted genes, RASAL2 and NENF, quantified by QPCR after first (I) and second (II) transfection of Hep3B HCC cell line with scrambled siRNA (siCtrl) and siRNA directed to…
View article: Supplementary Figure 1 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 1 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 961KB, Supplementary Figure S1. (A,B) Extensive methylation analysis of RASAL2 (A) and NENF (B) promoters in cells treated with 5-azaCdR, different cell lines and patients. Average methylation state of CpG sites was determined b…
View article: Supplementary Figure 7 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 7 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 690KB, Supplementary Figure S7. Impact of RASAL2 and NENF depletion on on expression of genes of DNA methylation machinery, DNMT1, MBD2, DNMT3A, and DNMT3B. DNMT1 (A), MBD2 (B), DNMT3A (C), and DNMT3B (D) expression levels quant…
View article: Supplementary Figure 3 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Supplementary Figure 3 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets Open
PDF file - 774KB, Supplementary Figure S3. RASAL2 and NENF are overexpressed in different types of human cancers. RASAL2 or NENF depletion decreases cancer cell growth and invasive capacities in liver cancer. Changes defined using differen…