Wasifa Naushad
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View article: Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation
Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation Open
The persistence of HIV latent reservoir is the major challenge to HIV cure because latent viruses serve as sources for viral rebound upon ART cessation. Mechanisms regulating viral persistence are not well understood; thus, there is a comp…
View article: Non-Vesicular Extracellular Particle (NVEP) Proteomes from Diverse Biological Sources Reveal Specific Marker Composition with Varying Enrichment Levels
Non-Vesicular Extracellular Particle (NVEP) Proteomes from Diverse Biological Sources Reveal Specific Marker Composition with Varying Enrichment Levels Open
Extracellular particles (EPs), an umbrella term encompassing membrane-enclosed extracellular vesicles (EVs) and non-vesicular extracellular particles ([NVEPs], previously described as extracellular condensates [ECs]) contain a complex carg…
View article: Lipidomic and proteomic insights from extracellular vesicles in the postmortem dorsolateral prefrontal cortex reveal substance use disorder-induced brain changes
Lipidomic and proteomic insights from extracellular vesicles in the postmortem dorsolateral prefrontal cortex reveal substance use disorder-induced brain changes Open
Substance use disorder (SUD) significantly increases the risk of neurotoxicity, inflammation, oxidative stress, and impaired neuroplasticity. The activation of inflammatory pathways by substances may lead to reactive astrogliosis and chron…
View article: Identification of HIV Tat and NF-κB binding proteins associated with semen-derived extracellular vesicles
Identification of HIV Tat and NF-κB binding proteins associated with semen-derived extracellular vesicles Open
Semen-derived extracellular vesicles (SEVs) have been shown to inhibit transactivation of the long terminal repeat (LTR) in human immunodeficiency virus type 1 (HIV-1, or HIV) and, hence, viral replication by blocking the interaction of th…
View article: Rigorous Process for Isolation of Gut-Derived Extracellular Vesicles (EVs) and the Effect on Latent HIV
Rigorous Process for Isolation of Gut-Derived Extracellular Vesicles (EVs) and the Effect on Latent HIV Open
The human gastrointestinal (GI) track host trillions of microorganisms that secrete molecules, including extracellular vesicles (EVs) and extracellular condensates (ECs) that may affect physiological and patho-physiological activities in t…
View article: Rigorous process for isolation of gut-derived extracellular vesicles and the effect on latent HIV
Rigorous process for isolation of gut-derived extracellular vesicles and the effect on latent HIV Open
Aim Extracellular particles (EPs) are produced/secreted by cells from all domains of life and are present in all body fluids, brain, and gut. EPs consist of extracellular vesicles (EVs) made up of exosomes, microvesicles, and other membran…
View article: Berberine: A dual anti-HIV and anti- cervical cancer compound
Berberine: A dual anti-HIV and anti- cervical cancer compound Open
View article: Berberine: A dual anti-HIV and anti- cervical cancer compound
Berberine: A dual anti-HIV and anti- cervical cancer compound Open
We report the effects of berberine (BBR), a benzylisoquinoline alkaloid small molecule on inhibition of HIV infection of cervical cancer cells. We used HeLa cell-derived TZM-bl cell line as a model of cervical cancer and HIV infection. BBR…
View article: Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation
Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation Open
Persistence of human immunodeficiency virus (HIV) latent reservoir is the major challenge to HIV cure because the latent reservoir is not eliminated by antiretroviral therapy (ART), and they serve as sources for viral rebound upon cessatio…
View article: Lipidomic and Proteomic Insights from Extracellular Vesicles in Postmortem Dorsolateral Prefrontal Cortex Reveal Substance Use Disorder-Induced Brain Changes
Lipidomic and Proteomic Insights from Extracellular Vesicles in Postmortem Dorsolateral Prefrontal Cortex Reveal Substance Use Disorder-Induced Brain Changes Open
Substance use disorder (SUD) significantly increases the risk of neurotoxicity, inflammation, oxidative stress, and impaired neuroplasticity. The activation of inflammatory pathways by substances may lead to glial activation and chronic ne…
View article: Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks
Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks Open
Summary Currently, obesity has achieved epidemic levels in reproductive‐aged women with a myriad of consequences. Obesity is susceptible to several reproductive complications that eventually affect fertility rates. These complications orig…
View article: SIV Infection Regulates Compartmentalization of Circulating Blood Plasma miRNAs within Extracellular Vesicles (EVs) and Extracellular Condensates (ECs) and Decreases EV-Associated miRNA-128
SIV Infection Regulates Compartmentalization of Circulating Blood Plasma miRNAs within Extracellular Vesicles (EVs) and Extracellular Condensates (ECs) and Decreases EV-Associated miRNA-128 Open
Background: This is Manuscript 1 of a two-part Manuscript of the same series. Here, we present findings from our first set of studies on the abundance and compartmentalization of blood plasma extracellular microRNAs (exmiRNAs) into extrace…
View article: Alterations in Abundance and Compartmentalization of miRNAs in Blood Plasma Extracellular Vesicles and Extracellular Condensates during HIV/SIV Infection and Its Modulation by Antiretroviral Therapy (ART) and Delta-9-Tetrahydrocannabinol (Δ9-THC)
Alterations in Abundance and Compartmentalization of miRNAs in Blood Plasma Extracellular Vesicles and Extracellular Condensates during HIV/SIV Infection and Its Modulation by Antiretroviral Therapy (ART) and Delta-9-Tetrahydrocannabinol (Δ9-THC) Open
In this follow-up study, we investigated the abundance and compartmentalization of blood plasma extracellular miRNA (exmiRNA) into lipid-based carriers—blood plasma extracellular vesicles (EVs) and non-lipid-based carriers—extracellular co…
View article: Epidemiological characteristics and genetic diversity of clinically isolated dengue vector in Khyber Pakhtunkhwa, Pakistan
Epidemiological characteristics and genetic diversity of clinically isolated dengue vector in Khyber Pakhtunkhwa, Pakistan Open
View article: SARS-CoV-2: big seroprevalence data from Pakistan—is herd immunity at hand?
SARS-CoV-2: big seroprevalence data from Pakistan—is herd immunity at hand? Open
View article: BST-2 promotes survival in circulation and pulmonary metastatic seeding of breast cancer cells
BST-2 promotes survival in circulation and pulmonary metastatic seeding of breast cancer cells Open
Bone marrow stromal antigen 2 (BST-2) mediates various facets of cancer progression and metastasis. Here, we show that BST-2 is linked to poor survival in invasive breast cancer patients as its expression positively correlates with disease…
View article: Structural determinant of BST-2-mediated regulation of breast cancer cell motility: a role for cytoplasmic tail tyrosine residues
Structural determinant of BST-2-mediated regulation of breast cancer cell motility: a role for cytoplasmic tail tyrosine residues Open
There is now irrefutable evidence that overexpression of the innate immunity protein-BST-2, in breast cancer cells is implicated in tumor growth and progression. The cellular mechanisms that control BST-2-mediated effect in tumor progressi…
View article: 96P MMTV and breast cancer: Integration sites of MMTV in breast cancer patients and their potential role in cancer progression
96P MMTV and breast cancer: Integration sites of MMTV in breast cancer patients and their potential role in cancer progression Open