David J. Wasilko
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View article: Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20 Open
Chemokines are important protein-signaling molecules that regulate various immune responses by activating chemokine receptors which belong to the G protein-coupled receptor (GPCR) superfamily.Despite the substantial progression of our stru…
View article: Insights into the ubiquitin transfer cascade catalyzed by the Legionella effector SidC
Insights into the ubiquitin transfer cascade catalyzed by the Legionella effector SidC Open
The causative agent of Legionnaires’ disease, Legionella pneumophila, delivers more than 330 virulent effectors to its host to establish an intracellular membrane-bound organelle called the Legionella containing vacuole. Among the army of …
View article: Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome
Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome Open
The opportunistic intracellular pathogen Legionella pneumophila is the causative agent of Legionnaires' disease. L. pneumophila delivers nearly 300 effector proteins into host cells for the establishment of a replication-permissive compart…