Explanipedia

Challenges and coping mechanisms among caregivers of children with orofacial cleft in a Nigerian teaching hospital: photovoice approach Open

Oluwafemi Adeagbo, Oluwaseun Badru, Bolaji Akala, Abimbola Oladayo, Adegbayi Adeola Adekunle , et al. · 2025

Introduction Children with Orofacial cleft (OFC) require specific support that can be challenging for their caregivers due to the various challenges associated with OFC. The use of photovoice in cleft research is scant. Thus, we used the p…

Effects of piezoelectric versus rotary handpiece on postoperative sequelae following surgical removal of impacted mandibular third molars; A comparative study Open

Ochuko Ebrorhie, Michael O. Adeyemi, Olawale Adamson, Emmanuel Onyebuchi Onuoha, Wasiu Lanre Adeyemo · 2025

Background: Bone removal is a key step in surgically extracting the impacted mandibular third molar and is chiefly responsible for the postoperative sequelae. The piezoelectric drill was introduced to help lessen the severity of these sequ…

The journey to institutionalising Antimicrobial Stewardship (AMS) in a resource-constrained tertiary healthcare facility in Lagos, Nigeria Open

Oyinlola O. Oduyebo, Iretiola Fajolu, C. A. Oluwarotimi, Adetola Toye, Olubusola A. Olugbake , et al. · 2025

Background: Antimicrobial stewardship (AMS) is one of the main strategies to stem the global tide of antimicrobial resistance (AMR). While developed nations have successfully implemented antimicrobial stewardship programmes, such initiativ…

Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy Open

Kelsey Robinson, Sunil Kumar Singh, Rachel B Walkup, Dorelle V. Fawwal, Wasiu Lanre Adeyemo , et al. · 2025

Van der Woude syndrome (VWS) is an autosomal dominant disorder characterized by lower lip pits and orofacial clefts (OFCs). With a prevalence of approximately 1 in 35,000 live births, it is the most common form of syndromic clefting and ma…

Multi-ancestry Genome Wide Association Study Meta-analysis of Non-syndromic Orofacial Clefts Open

Zhonglin Jia, Nandita Mukhopadhyay, Zheng-Lin YANG, Azeez Butali, Jialin Sun , et al. · 2024

Non-syndromic orofacial clefts (NSOC) are common craniofacial birth defects, and result from both genetic and environmental factors. NSOC include three major sub-phenotypes: non-syndromic cleft lip with palate (NSCLP), non-syndromic cleft …

Parental Age and Severity of Non-Syndromic Orofacial Clefts: Relationship with De Novo Mutations Open

Olawale Adamson, Abimbola V. Oladugba, Azeez Alade, Waheed Awotoye, Tamara Busch , et al. · 2024

Background: This study investigates the relationship between paternal and maternal age, and the severity of orofacial clefts and the presence of de novo mutations in children. Methods: This was a retrospective study of individuals who were…

Genome-wide study of gene-by-sex interactions identifies risks for cleft palate Open

Kelsey Robinson, Randy L. Parrish, Wasiu Lanre Adeyemo, Terri H. Beaty, Azeez Butali , et al. · 2024

Genome scan reveals several loci associated with torus palatinus Open

Myoung Keun Lee, Ahmed M. El Sergani, Noah Herrick, Rebecca M. Green, Carmencita D. Padilla , et al. · 2024

Objective Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic …

EVALUATION OF OROFACIAL CLEFT COMMUNITY AWARENESS STRATEGIES USED IN A TERTIARY HOSPITAL IN NIGERIA. Open

Adegbayi Adeola Adekunle, A A Adamson, Olutayo James, Wasiu Lanre Adeyemo, Mobolanle O. Ogunlewe · 2024

The results of this study show that campaigns focused on maternity homes and peripheral hospitals appear to be the most effective strategy and the single largest source of referrals to our cleft care programme.

Aggressive Periodontitis: A case report with exome sequencing and functional characterization of identified variant Open

Waheed Awotoye, Patricia Omowunmi Ayanbadejo, Steven Eliason, Kehinde Adesola Umeizudike, Ayodele Ogundana , et al. · 2024

Aggressive periodontitis (AgP) is characterized by rapid and progressive destruction of the periodontal tissues and eventual tooth loss. Genetic risk contributions have been explored and rare mutations in NOD2 were reported. Sequencing ana…

Rare variants analyses suggest novel cleft genes in the African population Open

Azeez Alade, Peter Mossey, Waheed Awotoye, Tamara Busch, Abimbola Oladayo , et al. · 2024

Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain only a small proportion of the heritability for NSOFCs. Rare variants have been imp…

Genome-wide study of gene-by-sex interactions identifies risks for cleft palate Open

Kelsey Robinson, Randy L. Parrish, Wasiu Lanre Adeyemo, Terri H. Beaty, Azeez Butali , et al. · 2024

Structural birth defects affect 3-4% of all live births and, depending on the type, tend to manifest in a sex-biased manner. Orofacial clefts (OFCs) are the most common craniofacial structural birth defects and are often divided into cleft…

Gene-Environment Interaction of Interleukin 10 Gene Polymorphism, rs1800896, with Lifestyle on Cardiovascular Risk in Type 2 Diabetes Open

Ifeoma Udenze, Idowu Adewunmi Taiwo, Casmir Amadi, Wasiu Lanre Adeyemo · 2024

Background: Gene–environment interactions play a major role in the phenotypic expression of complex disease traits such as those for cardiovascular diseases. Aims: This study aimed to determine the gene–environment interactions that underp…

Shared genetic risk between major orofacial cleft phenotypes in an African population Open

Azeez Alade, Tabitha Peter, Tamara Busch, Waheed Awotoye, Deepti Anand , et al. · 2024

Nonsyndromic orofacial clefts (NSOFCs) represent a large proportion (70%–80%) of all OFCs. They can be broadly categorized into nonsyndromic cleft lip with or without cleft palate (NSCL/P) and nonsyndromic cleft palate only (NSCPO). Althou…

Systematic Review and Meta-analysis of the Pattern, Distribution, Etiology, and Treatment of Maxillofacial Injuries From Different Geopolitical Zones in Nigeria Open

Ezekiel Taiwo Adebayo, Benjamin Fomete, Uchenna P. Egbunah, Timothy Aladelusi, Adegbayi Adeola Adekunle , et al. · 2024

Purpose: This study aimed to provide a nationwide survey of maxillofacial injuries pattern, distribution, etiology, and treatment based on Nigeria’s geopolitical zones. Methods: This systematic review and meta-analysis included all cross-s…

Rare Variants Analyses Suggest Novel Cleft Genes in the African Population Open

Azeez Alade, Peter Mossey, Waheed Awotoye, Tamara Busch, Abimbola Oladayo , et al. · 2024

Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain only a small proportion of the heritability for NSOFC. Rare variants have been impl…

Perceptions and beliefs of community gatekeepers about genomic risk information in African cleft research Open

Abimbola Oladayo, Oluwakemi Ololade Odukoya, Veronica Sule, Ikenna Daniel Molobe, Tamara Busch , et al. · 2024

Hepatitis B and C Virus Co-Infection and Their Association With Liver Disease in Persons With HIV in Nigeria Open

Emuobor Odeghe, Ganiyat K. Oyeleke, Mayowa Odofin, Mary Duguru, Pantong Davwar , et al. · 2024

Background: The burden of chronic viral hepatitis among people living with human immunodeficiency virus (PLWH) and its association with liver disease in Nigeria has been seldom explored. Our objective was to compare characteristics in PLWH…

Trio-based GWAS identifies novel associations and subtype-specific risk factors for cleft palate Open

Kelsey Robinson, Trenell J. Mosley, Kenneth S. Rivera-González, Christopher R. Jabbarpour, Sarah W. Curtis , et al. · 2023

Clinically actionable secondary findings in 130 triads from sub‐Saharan African families with non‐syndromic orofacial clefts Open

Abimbola Oladayo, Lord J. J. Gowans, Waheed Awotoye, Azeez Alade, Tamara Busch , et al. · 2023

Introduction The frequency and implications of secondary findings (SFs) from genomic testing data have been extensively researched. However, little is known about the frequency or reporting of SFs in Africans, who are underrepresented in l…

Achieving a robust mentoring and research capacity program in a LMIC – the BRAINS faculty development model Open

Folasade Ogunsola, Adekemi Sekoni, Sulaimon Akanmu, Wasiu Lanre Adeyemo, Akinniyi Osuntoki , et al. · 2023

Universal use of face mask for the prevention of the spread of COVID-19 in community settings in a South-western State of Nigeria: willingness and barriers Open

Folasade Ogunsola, Chioma Ejekam, Mobolanle Balogun, Igwilo Ugonna, Oluwakemi Ololade Odukoya , et al. · 2023

Otological Challenges in Patients With Non-Syndromic Cleft Lip and Palate: A Systematic Review Open

Olutayo James, Bright Otoghile, Olawale Adamson, Uchenna P. Egbunah, Vinishe Yakubu Sabo , et al. · 2023

Objectives: To identify the various otological challenges associated with non-syndromic orofacial clefts, how these problems affect quality of life of patients with orofacial clefts and find out the perspectives and current trends in the m…

Clinical Predictors of Covid-19 Mortality in a Tertiary Hospital in Lagos, Nigeria: A Retrospective Cohort Study Open

Iorhen E. Akase, PE Akintan, Erere Otrofanowei, Oluwarotimi Olopade, Gbenga Olorunfemi , et al. · 2023

A BSTRACT Background: The predictors of mortality among patients presenting with severe to critical disease in Nigeria are presently unknown. Aim: The aim of this study was to identify the predictors of mortality among patients with COVID-…

Trio-based GWAS identifies novel associations and subtype-specific risk factors for cleft palate Open

Kelsey Robinson, Trenell J. Mosley, Kenneth S. Rivera-González, Christopher R. Jabbarpour, Sarah W. Curtis , et al. · 2023

Orofacial clefts (OFCs) are the most common craniofacial birth defects and are often categorized into two etiologically distinct groups: cleft lip with or without cleft palate (CL/P) and isolated cleft palate (CP). CP is highly heritable, …

Pediatric Surgical Waitlist in Low Middle Income Countries During the COVID-19 Pandemic Open

Greg Klazura, Paul Park, Ava Yap, Ruth Laverde, Emma Bryce , et al. · 2023

Damaging Mutations in <b> <i>AFDN</i> </b> Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate Open

Waheed Awotoye, Peter Mossey, Jacqueline B. Hetmanski, Lord J. J. Gowans, Mekonen Eshete , et al. · 2022

Objectives Novel or rare damaging mutations have been implicated in the developmental pathogenesis of nonsyndromic cleft lip with or without cleft palate (nsCL ± P). Thus, we investigated the human genome for high-impact mutations that cou…

Implementation of a Non-Invasive Helmet Ventilation Solution for the Management of Severe COVID-19 Respiratory Disease in Nigeria: The CircumVent Project Open

Aima A. Ahonkhai, Aliyu Abdu, Olukemi Adekanmbi, Nnennaya Anthony Ajayi, Samuel Ajayi , et al. · 2022

Affordable novel strategies are needed to treat COVID-19 cases complicated by respiratory compromise in resource limited settings. We report a mixed-methods pre-post assessment of 1) the useability of CPAP/O2 helmet non-invasive ventilatio…

Investigating the relationship between cancer and orofacial clefts using GWAS significant loci for cancers: A case-control and case-triad study Open

Azeez Fashina, Tamara Busch, Mary Young, Olawale Adamson, Waheed Awotoye , et al. · 2022

Background Several population-based case-control studies have reported concurrent presentation of cancer and congenital malformations. Many associations have been made between oral clefting and cancers, though some of these results are con…

Achieving a Robust Mentoring and Research Capacity Program in a LMIC – The BRAINS Faculty Development Model Open

Folasade Ogunsola, Adekemi Sekoni, Madonna Emmanuel, Bibiane Manga‐Atangana, Sikeade Olawumi Caleb-Adepoju , et al. · 2022

Background: A research and training program (RTP) was carried out to build capacity of faculty and improve the culture of research in the College of Medicine, University of Lagos (CMUL), Nigeria.Methods: Realist guided mixed methods evalua…

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