Mark Cunningham
YOU?
Author Swipe
View article: The Daily Mile and children’s physical activity, mental health and educational performance: a quasi-experimental study in Greater London primary schools
The Daily Mile and children’s physical activity, mental health and educational performance: a quasi-experimental study in Greater London primary schools Open
Objectives To examine associations between The Daily Mile, a school-based active mile intervention, and pupils’ physical activity, mental health and educational performance. Methods Year 1 pupils (aged 5–6 years) from Greater London primar…
View article: Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure
Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure Open
Coronary artery bypass graft (CABG) surgery remains the gold standard of care to prevent myocardial ischemia in patients with advanced atherosclerosis; however, poor long-term graft patency remains a considerable and long-standing problem.…
View article: Exploring associations between active school environments and children’s physical activity, mental health and educational performance in Greater London primary schools: the Health and Activity of Pupils in the Primary Years (HAPPY) study protocol
Exploring associations between active school environments and children’s physical activity, mental health and educational performance in Greater London primary schools: the Health and Activity of Pupils in the Primary Years (HAPPY) study protocol Open
Introduction School environments that encourage children to be physically active can embed lifelong positive health behaviours and contribute towards reducing health inequalities. The Health and Activity of Pupils in the Primary Years (HAP…
View article: General practice antibiotic prescriptions attributable to respiratory syncytial virus by age and antibiotic class: an ecological analysis of the English population
General practice antibiotic prescriptions attributable to respiratory syncytial virus by age and antibiotic class: an ecological analysis of the English population Open
Background Respiratory syncytial virus (RSV) may contribute to a substantial volume of antibiotic prescriptions in primary care. However, data on the type of antibiotics prescribed for such infections are only available for children <5 …
View article: Microbial fuel cells to monitor natural attenuation around groundwater plumes
Microbial fuel cells to monitor natural attenuation around groundwater plumes Open
This research presents a straightforward and economically efficient design for a microbial fuel cell (MFC) that can be conveniently integrated into a borehole to monitor natural attenuation in groundwater. The design employs conventional, …
View article: General practice antibiotic prescriptions attributable to Respiratory Syncytial Virus by age and antibiotic class: An ecological analysis of the English population
General practice antibiotic prescriptions attributable to Respiratory Syncytial Virus by age and antibiotic class: An ecological analysis of the English population Open
Background Respiratory syncytial virus (RSV) may contribute to a substantial volume of antibiotic prescriptions in primary care. However, data on the type of antibiotics prescribed for such infections is only available for children <5 year…
View article: Reconstituted <scp>HDL</scp> ameliorated renal injury of diabetic kidney disease in mice
Reconstituted <span>HDL</span> ameliorated renal injury of diabetic kidney disease in mice Open
Diabetic kidney disease (DKD) is a devastating kidney disease and lacks effective therapeutic interventions. The present study was aimed to determine whether reconstituted high‐density lipoprotein (rHDL) ameliorated renal injury in eNOS −/…
View article: Bio-Electrochemical Systems to Monitor Biodegradation around Groundwater Plumes
Bio-Electrochemical Systems to Monitor Biodegradation around Groundwater Plumes Open
This study introduces a straightforward and cost-effective Bio-Electrochemical System (BES) design that can be easily retrofitted into a borehole. The design uses standard bailers and Granular Activated Carbon (GAC) to create electrodes. T…
View article: Progesterone‐induced blocking factor blockade causes hypertension in pregnant rats
Progesterone‐induced blocking factor blockade causes hypertension in pregnant rats Open
Preeclampsia (PE) is a multisystem disorder characterized by new onset hypertension in mid‐late gestation and can include multi‐organ dysfunction with or without proteinuria. It affects 5%–7% of all pregnancies in the U.S., making PE a maj…
View article: Regulatory Considerations Regarding Potential High Temperature Fluid Releases in Advanced Reactor Designs
Regulatory Considerations Regarding Potential High Temperature Fluid Releases in Advanced Reactor Designs Open
The current effort is supported by the U.S. Department of Energy (DOE), Advanced Reactor Demonstration Program (ARDP) Regulatory Development, Regulatory Framework Modernization area, which seeks to address potential regulatory challenges f…
View article: Preliminary data on the bacterial diversity of Dobšinská and Demänovská ice caves (Slovakia)
Preliminary data on the bacterial diversity of Dobšinská and Demänovská ice caves (Slovakia) Open
Our work brings preliminary data on the diversity of microorganisms in Dobšinská and Demänovská ice caves (Slovakia). The caves are located at about 80 km from each other. Demänovská Ice Cave is part of the Demänovské caves system, located…
View article: Success Path Method: Implementation Guidance
Success Path Method: Implementation Guidance Open
This document provides a guide regarding the application of the Argonne National Laboratory (Argonne) Success Path Method (SPM) for the management of risk(s) of processes associated with organizational objectives. The current work provides…
View article: Characterization of Mitochondrial Bioenergetics in Preeclampsia
Characterization of Mitochondrial Bioenergetics in Preeclampsia Open
Preeclampsia (PE) is characterized by new onset hypertension during pregnancy and is associated with oxidative stress, placental ischemia, and autoantibodies to the angiotensin II type I receptor (AT1-AA). Mitochondrial (mt) dysfunction in…
View article: Angiotensin II Type 1 Receptor Agonistic Autoantibody Blockade Improves Postpartum Hypertension and Cardiac Mitochondrial Function in Rat Model of Preeclampsia
Angiotensin II Type 1 Receptor Agonistic Autoantibody Blockade Improves Postpartum Hypertension and Cardiac Mitochondrial Function in Rat Model of Preeclampsia Open
Women with preeclampsia (PE) have a greater risk of developing hypertension, cardiovascular disease (CVD), and renal disease later in life. Angiotensin II type I receptor agonistic autoantibodies (AT1-AAs) are elevated in women with PE dur…
View article: Progesterone-induced blocking factor improves blood pressure, inflammation, and pup weight in response to reduced uterine perfusion pressure (RUPP)
Progesterone-induced blocking factor improves blood pressure, inflammation, and pup weight in response to reduced uterine perfusion pressure (RUPP) Open
Preeclampsia (PE) is characterized by new-onset hypertension in association with elevated natural killer (NK) cells and inflammatory cytokines, which are likely culprits for decreased fetal weight during PE pregnancies. As progesterone inc…
View article: The Role of Mitochondrial Dysfunction in Preeclampsia: Causative Factor or Collateral Damage?
The Role of Mitochondrial Dysfunction in Preeclampsia: Causative Factor or Collateral Damage? Open
Preeclampsia, new onset hypertension in pregnancy, affects ~5%–10% of the world’s population. Preeclampsia is the leading cause of morbidity and mortality for both the mother and fetus. As of today, there is no cure for this disease except…
View article: Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia
Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia Open
TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.
View article: RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models Open
The RUPP procedure is a well-established model for studying the link between placental ischemia and hypertension in the pregnant rat and has been described in detail previously.( 1) First timed pregnant Sprague-Dawley rats purchased from H…
View article: Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia
Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia Open
Preeclampsia (PE) is characterized by new-onset hypertension that usually occurs in the third trimester of pregnancy and is associated with oxidative stress and angiotensin II type 1 receptor agonistic autoantibodies (AT 1 -AAs). Inhibitio…