Lennard W. Duck
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View article: Colonocytes targeted by Citrobacter rodentium elicit epithelial MHCII-restricted help from CD4 T cells 2044
Colonocytes targeted by Citrobacter rodentium elicit epithelial MHCII-restricted help from CD4 T cells 2044 Open
Description IL-22+ CD4 T cells play a key role in intestinal defense against the murine pathogen Citrobacter rodentium (C.r), yet the direct interactions between T cells and intestinal epithelial cells (IECs) remains unclear. Our study sho…
View article: Diversity of motility gene signatures distinguishes commensal Clostridia that elicit divergent host immune responses
Diversity of motility gene signatures distinguishes commensal Clostridia that elicit divergent host immune responses Open
Adaptive immune responses to commensal flagellins are hallmarks of Crohns disease, but it is unclear whether flagellins themselves promote inflammation or whether flagellated commensals can also be colitogenic. Here, we show that the arran…
View article: Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition Open
Background: Breast cancer (BC) is the second most common cancer among women in the United States. It has been estimated that one in eight women will be diagnosed with breast cancer in her lifetime. Various BC risk factors, such as age, phy…
View article: A159 SERUM IGG RESPONSE TO THE D0-D1 HINGE PEPTIDE OF COMMENSAL FLAGELLIN PREDICTS THE FUTURE ONSET OF CROHN’S DISEASE IN HEALTHY FIRST-DEGREE RELATIVES
A159 SERUM IGG RESPONSE TO THE D0-D1 HINGE PEPTIDE OF COMMENSAL FLAGELLIN PREDICTS THE FUTURE ONSET OF CROHN’S DISEASE IN HEALTHY FIRST-DEGREE RELATIVES Open
Background Elevated antimicrobial antibody levels have been reported up to 6 years before diagnosis of Crohn’s disease (CD), but the specific antibody response is poorly defined. Aims Here, we characterized the nature of the antimicrobial …
View article: Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence
Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence Open
Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier 1–3 . T cells, but not innate lymphoid cells, have an indispensable role in sustaining the IL-22 signalling that is required for the protection of …
View article: Crohn’s patients and healthy infants share immunodominant B cell response to commensal flagellin peptide epitopes
Crohn’s patients and healthy infants share immunodominant B cell response to commensal flagellin peptide epitopes Open
About half of patients with Crohn’s disease (CD) develop selective serum IgG response to flagellin proteins of the Lachnospiraceae family. Here, we identified a dominant B cell peptide epitope in CD, locating in the highly conserved “hinge…
View article: Remodeling of colon plasma cell repertoire within ulcerative colitis patients
Remodeling of colon plasma cell repertoire within ulcerative colitis patients Open
Plasma cells (PCs) constitute a significant fraction of colonic mucosal cells and contribute to inflammatory infiltrates in ulcerative colitis (UC). While gut PCs secrete bacteria-targeting IgA antibodies, their role in UC pathogenesis is …
View article: ICOS ligand and IL-10 synergize to promote host–microbiota mutualism
ICOS ligand and IL-10 synergize to promote host–microbiota mutualism Open
Significance Both IL10 and ICOSL are risk alleles for inflammatory bowel disease (IBD). The role of IL-10 in preventing gut inflammation is well established experimentally and clinically. However, it is unclear whether and how ICOSL functi…
View article: DOP09 IgG responses to multiple bacterial flagellins identify a subgroup of paediatric therapy-naive Crohn’s disease patients with increased microbiota-specific T-cell reactivity
DOP09 IgG responses to multiple bacterial flagellins identify a subgroup of paediatric therapy-naive Crohn’s disease patients with increased microbiota-specific T-cell reactivity Open
Background inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic intestinal disease driven by inflammatory T-cell responses thought to target intestinal bacteria. However, evidence for …
View article: Commensal A4 bacteria inhibit intestinal Th2‐cell responses through induction of dendritic cell TGF‐β production
Commensal A4 bacteria inhibit intestinal Th2‐cell responses through induction of dendritic cell TGF‐β production Open
It has been shown that while commensal bacteria promote Th1, Th17 and Treg cells in lamina propria (LP) in steady‐state conditions, they suppress mucosal Th2 cells. However, it is still unclear whether there are specific commensal organism…