Wayne I. Doyle
YOU?
Author Swipe
View article: Single nucleus multi-omics identifies human cortical cell regulatory genome diversity
Single nucleus multi-omics identifies human cortical cell regulatory genome diversity Open
Single-cell technologies measure unique cellular signatures but are typically limited to a single modality. Computational approaches allow the fusion of diverse single-cell data types, but their efficacy is difficult to validate in the abs…
View article: Physiology-forward identification of bile acid–sensitive vomeronasal receptors
Physiology-forward identification of bile acid–sensitive vomeronasal receptors Open
A GCaMP6-based ligand-receptor screen identified five bile acid receptors in the mouse vomeronasal organ.
View article: An integrated transcriptomic and epigenomic atlas of mouse primary motor cortex cell types
An integrated transcriptomic and epigenomic atlas of mouse primary motor cortex cell types Open
Single cell transcriptomics has transformed the characterization of brain cell identity by providing quantitative molecular signatures for large, unbiased samples of brain cell populations. With the proliferation of taxonomies based on ind…
View article: Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variants
Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variants Open
Single-cell technologies enable measure of unique cellular signatures, but are typically limited to a single modality. Computational approaches allow integration of diverse single-cell datasets, but their efficacy is difficult to validate …
View article: Physiology-forward identification of bile acid sensitive vomeronasal receptors
Physiology-forward identification of bile acid sensitive vomeronasal receptors Open
/Summary The mouse accessory olfactory system (AOS) supports social and reproductive behavior through the sensation of environmental chemosignals. A growing number of excreted steroids have been shown to be potent AOS cues, including bile …
View article: Excreted Steroids in Vertebrate Social Communication
Excreted Steroids in Vertebrate Social Communication Open
Steroids play vital roles in animal physiology across species, and the production of specific steroids is associated with particular internal biological functions. The internal functions of steroids are, in most cases, quite clear. However…
View article: Heterogeneous effects of norepinephrine on spontaneous and stimulus-driven activity in the male accessory olfactory bulb
Heterogeneous effects of norepinephrine on spontaneous and stimulus-driven activity in the male accessory olfactory bulb Open
Norepinephrine (NE) release has been linked to experience-dependent plasticity in many model systems and brain regions. Among these is the rodent accessory olfactory system (AOS), which is crucial for detecting and processing socially rele…
View article: Faecal bile acids are natural ligands of the mouse accessory olfactory system
Faecal bile acids are natural ligands of the mouse accessory olfactory system Open
The accessory olfactory system (AOS) guides behaviours that are important for survival and reproduction, but understanding of AOS function is limited by a lack of identified natural ligands. Here we report that mouse faeces are a robust so…