Wen‐chang Lin
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View article: A visualization tool for individual gene expression profiles among males and females in GTEx tissues
A visualization tool for individual gene expression profiles among males and females in GTEx tissues Open
Sexual dimorphism has been implied to certain human physiology and diseases. This topic has recently garnered more attention, highlighting individual variances in precision medicine and individualized clinical trials. It is recognized that…
View article: Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis
Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis Open
Background Obstructive sleep apnea (OSA) and major depressive disorder (MDD) impose substantial quality-of-life burdens and socioeconomic costs. Growing evidence indicates bidirectional disease interactions that exacerbate clinical outcome…
View article: A machine learning-derived immune-related prognostic model identifies PLXNA3 as a functional risk gene in colorectal cancer
A machine learning-derived immune-related prognostic model identifies PLXNA3 as a functional risk gene in colorectal cancer Open
Introduction Colorectal Cancer (CRC) remains a leading cause of cancer-related mortality, characterized by substantial interpatient heterogeneity and limited effective prognostic biomarkers. Methods To address this gap, we constructed a ro…
View article: Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy Open
Background: Aggregation-induced emission (AIE)-based photodynamic therapy (PDT) represents a promising strategy for cancer treatment for its capacity to activate specific cell death pathways through pronounced oxidative stress. While the a…
View article: Rapid and supersensitive allele detection of Plasmodium falciparum chloroquine resistance via a Pyrococcus furiosus argonaute-triggered dual-signal biosensing platform
Rapid and supersensitive allele detection of Plasmodium falciparum chloroquine resistance via a Pyrococcus furiosus argonaute-triggered dual-signal biosensing platform Open
Background Malaria remains a serious public health problem worldwide, particularly in Africa. Resistance to antimalarial drugs is an essential issue for malaria control and elimination. Currently, polymerase chain reaction (PCR) combined w…
View article: Identifying Multiomic Signatures of X‐Linked Retinoschisis‐Derived Retinal Organoids and Mice Harboring Patient‐Specific Mutation Using Spatiotemporal Single‐Cell Transcriptomics
Identifying Multiomic Signatures of X‐Linked Retinoschisis‐Derived Retinal Organoids and Mice Harboring Patient‐Specific Mutation Using Spatiotemporal Single‐Cell Transcriptomics Open
X‐linked retinoschisis (XLRS) is an inherited retinal disorder with severe retinoschisis and visual impairments. Multiomics approaches integrate single‐cell RNA‐sequencing (scRNA‐seq) and spatiotemporal transcriptomics (ST) offering potent…
View article: Neutrophils Recruited by NKX2‐1 Suppression via Activation of CXCLs/CXCR2 Axis Promote Lung Adenocarcinoma Progression
Neutrophils Recruited by NKX2‐1 Suppression via Activation of CXCLs/CXCR2 Axis Promote Lung Adenocarcinoma Progression Open
NK2 Homeobox 1 (NKX2‐1) is a well‐characterized pathological marker that delineates lung adenocarcinoma (LUAD) progression. The advancement of LUAD is influenced by the immune tumor microenvironment through paracrine signaling. However, th…
View article: Distinguish inverse Gottron’s papules and inverse Gottron’s sign in anti-MDA5 dermatomyositis
Distinguish inverse Gottron’s papules and inverse Gottron’s sign in anti-MDA5 dermatomyositis Open
Journal Article Corrected proof Distinguish inverse Gottron's papules and inverse Gottron's sign in anti-MDA5 dermatomyositis Get access W Lin, W Lin Department of Rheumatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medi…
View article: Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition
Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition Open
Cancer has been linked to metabolic disorders and diverse gene mutations. Metformin, which is widely used to treat type 2 diabetes, inhibits the growth of cancer cells in animal models. Here we investigated the effects of metformin on huma…
View article: Hepatitis B virus virion secretion is a CRM1-spike-mediated late event
Hepatitis B virus virion secretion is a CRM1-spike-mediated late event Open
Background Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found that nuclear export…
View article: Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis
Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis Open
Circular RNAs (circRNAs) are noncoding products of backsplicing of pre-mRNAs which have been established to possess potent biological functions. Dysregulated circRNA expression has been linked to diseases including different types of cance…
View article: Strategic Decoy Peptides Interfere with MSI1/AGO2 Interaction to Elicit Tumor Suppression Effects
Strategic Decoy Peptides Interfere with MSI1/AGO2 Interaction to Elicit Tumor Suppression Effects Open
Peptide drugs that target protein–protein interactions have attracted mounting research efforts towards clinical developments over the past decades. Increasing reports have indicated that expression of Musashi 1 (MSI1) is tightly correlate…
View article: TEx-MST: tissue expression profiles of MANE select transcripts
TEx-MST: tissue expression profiles of MANE select transcripts Open
Recently, a new reference transcript dataset [Matched Annotation from the NCBI and EMBL-EBI (MANE) select] was released by NCBI and EMBL-EBI to make available a new unified representative transcript for human protein-coding genes. While th…
View article: Exploration of deep-learning based classification with human SNP image graphs
Exploration of deep-learning based classification with human SNP image graphs Open
Background With the advancement of NGS platform, large numbers of human variations and SNPs are discovered in human genomes. It is essential to utilize these massive nucleotide variations for the discovery of disease genes and human phenot…
View article: Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression
Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression Open
Glioblastoma (GBM) is the most malignant brain tumor which is characterized by high proliferation and migration capacity. The poor survival rate has been attributed to limitations of the current standard therapies. The search for novel bio…
View article: 405 Impact of hyperthermic intraperitoneal chemotherapy (HIPEC) on tumor microenvironment (TME) in ovarian cancer – a subanalysis from a Phase I clinical trial
405 Impact of hyperthermic intraperitoneal chemotherapy (HIPEC) on tumor microenvironment (TME) in ovarian cancer – a subanalysis from a Phase I clinical trial Open
Background Immunogenic cell death has been suggested as a mechanism for HIPEC, through the release of heat shock proteins, and resulting in activation of tumor-specific T cells. Methods This is a subgroup analysis of a Phase I trial using …
View article: Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset
Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset Open
With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene transcript compositions. However, alternatively compounded patterns of human protein-coding gene transcripts would c…
View article: Characterization of an IMP-4-Producing Klebsiella pneumoniae ST1873 Strain Recovered from an Infant with a Bloodstream Infection in China
Characterization of an IMP-4-Producing Klebsiella pneumoniae ST1873 Strain Recovered from an Infant with a Bloodstream Infection in China Open
Juan Xu, 1,* Wenping Lin, 2,* Yanmin Chen, 3 Fang He 3 1Institute of Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 310013, People’s Republic of China; 2Centers for Disease Control and…
View article: miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies
miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies Open
MicroRNAs (miRNAs) have been identified in many organisms, and they are essential for gene expression regulation in many critical cellular processes. The expression levels of these genes and miRNAs are closely associated with the progressi…
View article: Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2
Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2 Open
Carcinomatous progression and recurrence are the main therapeutic challenges frequently faced by patients with refractory tumors. However, the underlined molecular mechanism remains obscure. Methods: We found Musashi-1 (MSI1) transported i…
View article: Overlapping protein-coding genes in human genome and their coincidental expression in tissues
Overlapping protein-coding genes in human genome and their coincidental expression in tissues Open
The completion of human genome sequences and the advancement of next-generation sequencing technologies have engendered a clear understanding of all human genes. Overlapping genes are usually observed in compact genomes, such as those of b…
View article: The role of PEG3 in the occurrence and prognosis of colon cancer
The role of PEG3 in the occurrence and prognosis of colon cancer Open
Ting Zhou,1–4 Wei Lin,5 Qiongni Zhu,6 Helen Renaud,7 Xiaowei Liu,8 Ruidong Li,9 Cui Tang,1–4 Chong Ma,1–4 Tai Rao,1–4 Zhirong Tan,1–4 Ying Guo1–41Department of Clinical Pharmacology, Xiangya Hospital, Ce…
View article: Identification, chromosomal arrangements and expression analyses of the evolutionarily conserved prmt1 gene in chicken in comparison with its vertebrate paralogue prmt8
Identification, chromosomal arrangements and expression analyses of the evolutionarily conserved prmt1 gene in chicken in comparison with its vertebrate paralogue prmt8 Open
Nine protein arginine methyltransferases (PRMTs) are conserved in mammals and fish. Among these, PRMT1 is the major type I PRMT for asymmetric dimethylarginine (ADMA) formation and is the most conserved and widely distributed one. Two chic…
View article: A GDF15 3′ UTR variant, rs1054564, results in allele-specific translational repression of GDF15 by hsa-miR-1233-3p
A GDF15 3′ UTR variant, rs1054564, results in allele-specific translational repression of GDF15 by hsa-miR-1233-3p Open
Growth differentiation factor 15 (GDF15) is a strong predictor of cardiovascular events and mortality in individuals with or without cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) target sites, also kno…
View article: A Comprehensive Analysis of Transcript-Supported De Novo Genes in Saccharomyces sensu stricto Yeasts
A Comprehensive Analysis of Transcript-Supported De Novo Genes in Saccharomyces sensu stricto Yeasts Open
Novel genes arising from random DNA sequences (de novo genes) have been suggested to be widespread in the genomes of different organisms. However, our knowledge about the origin and evolution of de novo genes is still limited. To systemati…
View article: Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer
Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer Open
Many reports have implicated that microRNAs involve in cancer development and progression, such as miR-155 in breast cancers and miR-196 in gastric cancers. Furthermore, microRNAs are more stable than typical protein-coding gene mRNAs in v…