Wei Boon Yap
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View article: Mechanistic Insights into Hepatic Pathogenesis of Dengue Virus Serotype-2: Host–Virus Interactions, Immune Dysregulation, and Therapeutic Perspectives
Mechanistic Insights into Hepatic Pathogenesis of Dengue Virus Serotype-2: Host–Virus Interactions, Immune Dysregulation, and Therapeutic Perspectives Open
Dengue virus serotype 2 (DENV-2) is a predominant cause of severe dengue and a key determinant of dengue-associated liver injury. This review integrates recent findings on the molecular and cellular mechanisms of DENV-2 hepatotropism, focu…
View article: Dengue and Flavivirus Co-Infections: Challenges in Diagnosis, Treatment, and Disease Management
Dengue and Flavivirus Co-Infections: Challenges in Diagnosis, Treatment, and Disease Management Open
Co-infections of dengue serotypes and dengue with other flaviviruses pose substantial hurdles in disease diagnosis, treatment options, and disease management. The overlapping geographic distributions and mosquito vectors significantly enha…
View article: Influenza A virus H5N1: Histopathology, Mortality, Preventive and Therapeutic Approaches and Future Prospects
Influenza A virus H5N1: Histopathology, Mortality, Preventive and Therapeutic Approaches and Future Prospects Open
Influenza A virus H5N1 remains a significant global health concern due to its high pathogenicity and potential for zoonotic transmission. This review explores the pathological impact of H5N1 infection, emphasizing its severe effects on the…
View article: An Immunoinformatic Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses
An Immunoinformatic Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses Open
Background/Objectives: The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has exposed the vulnerabilities and unpreparedness of the global healthcare system in dealing with emerging…
View article: Insights into the Replication Kinetics Profiles of Malaysian SARS-CoV-2 Variant Alpha, Beta, Delta, and Omicron in Vero E6 Cell Line
Insights into the Replication Kinetics Profiles of Malaysian SARS-CoV-2 Variant Alpha, Beta, Delta, and Omicron in Vero E6 Cell Line Open
Comprehending the replication kinetics of SARS-CoV-2 variants helps explain why certain variants spread more easily, are more contagious, and pose a significant health menace to global populations. The replication kinetics of the Malaysian…
View article: An Immunoinformatics Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses
An Immunoinformatics Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses Open
The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has exposed the vulnerabilities and unpreparedness of the global healthcare system in dealing with emerging zoonoses. In the past …
View article: Insights into the Replication Kinetics Profiles of Malaysian SARS-CoV-2 Variant Alpha, Beta, Delta, and Omicron in Vero E6 cell line
Insights into the Replication Kinetics Profiles of Malaysian SARS-CoV-2 Variant Alpha, Beta, Delta, and Omicron in Vero E6 cell line Open
Comprehending the replication kinetics of SARS-CoV-2 variants helps explain why certain var-iants spread more easily and are more contagious, and pose significant health menaces to the global populations. The replication kinetics of Malays…
View article: Potential of Interleukin (IL)-12 Group as Antivirals: Severe Viral Disease Prevention and Management
Potential of Interleukin (IL)-12 Group as Antivirals: Severe Viral Disease Prevention and Management Open
The interleukin (IL)-12 family consists of pro- and anti-inflammatory cytokines that are able to signal the activation of host antiviral immunity while preventing over-reactive immune reactions due to active virus replication and viral cle…
View article: Prospective Roles of Tumor Necrosis Factor-Alpha (TNF-α) in COVID-19: Prognosis, Therapeutic and Management
Prospective Roles of Tumor Necrosis Factor-Alpha (TNF-α) in COVID-19: Prognosis, Therapeutic and Management Open
The coronavirus disease 2019 (COVID-19) became a worldwide concern at the beginning of 2020 and has affected millions. Several previous studies revealed the impact of the imbalanced innate immune response on the progression of COVID-19 and…
View article: Expression of Influenza M2e-NP Recombinant Fusion Protein in Escherichia coli BL21 (DE3) and Its Binding to Antibodies
Expression of Influenza M2e-NP Recombinant Fusion Protein in Escherichia coli BL21 (DE3) and Its Binding to Antibodies Open
The current influenza vaccines only confer protection against the circulating influenza subtypes, therefore universal vaccines are needed to prevent upcoming influenza outbreaks caused by emerging influenza subtypes. The extracellular doma…
View article: Dengue Virus Non-structural (NS) 1 Gene as A Molecular Marker for Early Detection of in vitro Dengue Virus Infection
Dengue Virus Non-structural (NS) 1 Gene as A Molecular Marker for Early Detection of in vitro Dengue Virus Infection Open
Serology-based dengue assays at times produce inaccurate results especially in the early phase of disease onset. A more precise diagnostic approach detecting dengue infections in the early phase enables better management of the disease. Th…
View article: M2e-Based Influenza Vaccines with Nucleoprotein: A Review
M2e-Based Influenza Vaccines with Nucleoprotein: A Review Open
Discovery of conserved antigens for universal influenza vaccines warrants solutions to a number of concerns pertinent to the currently licensed influenza vaccines, such as annual reformulation and mismatching with the circulating subtypes.…
View article: Regulation of Pro-Apoptotic Bax and Trail Gene Expressions by H5N1 in Madin-Darby Canine Kidney (Mdck) Cell Line
Regulation of Pro-Apoptotic Bax and Trail Gene Expressions by H5N1 in Madin-Darby Canine Kidney (Mdck) Cell Line Open
Avian influenza virus (AIV) A H5N1 is able to cause zoonosis with high morbidity and mortality. Several studies suggested the regulation of cellular apoptosis for virus survival by influenza viruses. This sheds light on the development of …
View article: Potentials of interleukin-27 (IL-27) as an immunotherapeutic cytokine in cancer therapy
Potentials of interleukin-27 (IL-27) as an immunotherapeutic cytokine in cancer therapy Open
Cancer immunotherapy using cytokines has been sought as an alternative therapeutic approach for treating cancers. Besides remarkable immunoregulatory properties, interleukin (IL)-27 has recently been shown to possess promising anticancer f…
View article: Endophytic fungi from Maliau Basin, Sabah: Identification of strains and antimicrobial compounds
Endophytic fungi from Maliau Basin, Sabah: Identification of strains and antimicrobial compounds Open
Aims: Endophytic fungi are microorganisms that live asymptomatically within plant tissues, producing a wide range of metabolites, including compounds potentially useful for drug development.We investigated endophytic fungi from Maliau Basi…
View article: Cytotoxicity, Regulation of Apoptotic and Anti-apoptotic Gene Expression by IL-27 in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines
Cytotoxicity, Regulation of Apoptotic and Anti-apoptotic Gene Expression by IL-27 in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines Open
Breast cancer is one of the commonest cancers among women. Conventional therapies cause adverse side effects in patients. Cytokine immunotherapy such as interleukin-27 (IL-27) has been sought as an alternative cancer treatment in recent ye…
View article: Universal Oral Vaccine for Influenza Infections
Universal Oral Vaccine for Influenza Infections Open
Each year, influenza A infections have caused tremendous death rate as high as 300,000-500,000 globally. Although there are effective anti-influenza agents and vaccines, high mutational rate among influenza A viruses renders dramatic decli…
View article: Cytotoxicity, Regulation of Apoptotic and Anti-apoptotic Gene Expression by IL-27 in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines
Cytotoxicity, Regulation of Apoptotic and Anti-apoptotic Gene Expression by IL-27 in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines Open
Breast cancer is one of the commonest cancers among women. Conventional therapies cause adverse side effects in patients. Cytokine immunotherapy such as interleukin-27 (IL-27) has been sought as an alternative cancer treatment in recent ye…
View article: Potentials of interleukin-27 (IL-27) as an immunotherapeutic cytokine in cancer therapy
Potentials of interleukin-27 (IL-27) as an immunotherapeutic cytokine in cancer therapy Open
Cancer immunotherapy using cytokines has been sought as an alternative therapeutic approach for treating cancers. Besides remarkable immunoregulatory properties, interleukin (IL)-27 has recently been shown to possess promising anticancer f…
View article: Expression of surface-bound nonstructural 1 (NS1) protein of influenza virus A H5N1 on<i>Lactobacillus casei</i>strain C1
Expression of surface-bound nonstructural 1 (NS1) protein of influenza virus A H5N1 on<i>Lactobacillus casei</i>strain C1 Open
The study has demonstrated, for the first time, the expression of nonstructural 1 (NS1) protein of influenza A virus H5N1 on the cell wall of Lactobacillus casei using the pSGANC332 expression plasmid. Display of NS1 protein on the bacteri…