Wei-Che Ko
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View article: Leveraging tissue-resident memory T cells for non-invasive immune monitoring via microneedle skin patches
Leveraging tissue-resident memory T cells for non-invasive immune monitoring via microneedle skin patches Open
Detecting antigen-specific lymphocytes is crucial for immune monitoring in the setting of vaccination, infectious disease, cancer, and autoimmunity. However, their low frequency and dispersed distribution across lymphoid organs, peripheral…
View article: Systemic and skin-limited delayed-type drug hypersensitivity reactions associate with distinct resident and recruited T cell subsets
Systemic and skin-limited delayed-type drug hypersensitivity reactions associate with distinct resident and recruited T cell subsets Open
Delayed-type drug hypersensitivity reactions are major causes of morbidity and mortality. The origin, phenotype, and function of pathogenic T cells across the spectrum of severity require investigation. We leveraged recent technical advanc…
View article: II-01 TLR9-deficiency exacerbates autoimmune disease in models of SLE and cutaneous lupus through B cell independent mechanisms
II-01 TLR9-deficiency exacerbates autoimmune disease in models of SLE and cutaneous lupus through B cell independent mechanisms Open
Background TLR9 appears to play both a protective and a disease-promoting role in animal models of SLE. Even though TLR9 is required for the production of anti-dsDNA and anti-nucleosome autoantibodies, TLR9-deficient autoimmune-prone mice …
View article: Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation
Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation Open
Toll-like receptors TLR7 and TLR9 are both implicated in the activation of autoreactive B cells and other cell types associated with systemic lupus erythematosus (SLE) pathogenesis. However, Tlr9-/- autoimmune-prone strains paradoxically d…