Wei‐Chieh Lee
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View article: Evaluating the Impact of Catheter Ablation on Cardiovascular and Cerebral Outcomes in Atrial Fibrillation With Heart Failure and Preserved Ejection Fraction
Evaluating the Impact of Catheter Ablation on Cardiovascular and Cerebral Outcomes in Atrial Fibrillation With Heart Failure and Preserved Ejection Fraction Open
Background Evidence supporting catheter ablation (CA) for atrial fibrillation (AF) in heart failure with preserved ejection fraction (HFpEF) is limited. This study evaluated the impact of CA on clinical outcomes in patients with AF and HFp…
View article: Long-Term Prognostic Value of Global Myocardial Work in Patients With Heart Failure With Mildly Reduced Ejection Fraction
Long-Term Prognostic Value of Global Myocardial Work in Patients With Heart Failure With Mildly Reduced Ejection Fraction Open
GWI is an independent prognostic marker for HHF in HFmrEF, offering incremental value beyond conventional echocardiographic parameters. However, validation in prospective and multicenter studies is warranted.
View article: Long-Term Outcomes of Anticoagulation Monotherapy Versus Combination Therapy in Atrial Fibrillation Patients with Complex Coronary Artery Disease
Long-Term Outcomes of Anticoagulation Monotherapy Versus Combination Therapy in Atrial Fibrillation Patients with Complex Coronary Artery Disease Open
View article: Statins and Pacing-Induced Atrial Myopathy: Unraveling Their Role in Atrioventricular Block Patients with Permanent Pacemakers
Statins and Pacing-Induced Atrial Myopathy: Unraveling Their Role in Atrioventricular Block Patients with Permanent Pacemakers Open
Background: Left atrial (LA) myopathy from interventricular dyssynchrony often precedes atrial fibrillation (AF) in atrioventricular block (AVB) patients with frequent right ventricular (RV) pacing, but the role of statin therapy in…
View article: 2025 THRS Expert Consensus of Imaging Assessment in Atrial Fibrillation. <i>Developed by the Task Force of the Taiwan Heart Rhythm Society (THRS) Imaging Committee. Endorsed by the Taiwan Society of Cardiology (TSOC)</i>.
2025 THRS Expert Consensus of Imaging Assessment in Atrial Fibrillation. <i>Developed by the Task Force of the Taiwan Heart Rhythm Society (THRS) Imaging Committee. Endorsed by the Taiwan Society of Cardiology (TSOC)</i>. Open
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia in the elderly population with a high lifetime risk after the age of 45 years, leading to a major impact on the public health from elicited left atrial (LA) thrombogene…
View article: Evaluating the Impact of Catheter Ablation on Cardiovascular and Cerebral Outcomes in Atrial Fibrillation with Heart Failure and Preserved Ejection Fraction
Evaluating the Impact of Catheter Ablation on Cardiovascular and Cerebral Outcomes in Atrial Fibrillation with Heart Failure and Preserved Ejection Fraction Open
Background Evidence supporting catheter ablation (CA) for atrial fibrillation (AF) in heart failure with preserved ejection fraction (HFpEF) is limited. This study evaluated the impact of CA on clinical outcomes in patients with AF and HFp…
View article: Enhanced ventricular synchrony and myocardial function with bipolar left bundle area pacing: a comparative study of anodal ring capture versus unipolar pacing
Enhanced ventricular synchrony and myocardial function with bipolar left bundle area pacing: a comparative study of anodal ring capture versus unipolar pacing Open
Aims Cardiac pacing aims to replicate physiological heart rhythm. While left bundle area pacing (LBAP) enhances left ventricular (LV) activation, it often struggles to fully address interventricular dyssynchrony. Bipolar LBAP with anodal r…
View article: Comparison of Clinical Outcomes between Newly Diagnosed andPre-Existing Diabetes Mellitus Patients after Acute Coronary Syndrome
Comparison of Clinical Outcomes between Newly Diagnosed andPre-Existing Diabetes Mellitus Patients after Acute Coronary Syndrome Open
Aim: This study aimed to evaluate clinical outcomes, including recurrent acute coronary syndrome (ACS) and mortality, in ACS patients with varying HbA1c levels, addressing the controversy over optimal targets in those with newly diagnosed …
View article: Dapagliflozin and Sirtuin-1 interaction and mechanism for ameliorating atrial fibrillation in a streptozotocin-induced rodent diabetic model
Dapagliflozin and Sirtuin-1 interaction and mechanism for ameliorating atrial fibrillation in a streptozotocin-induced rodent diabetic model Open
The incidence of atrial fibrillation (AF) increases with age and is particularly high in individuals with diabetes. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), such as dapagliflozin, show promise in treating heart failure (HF) and …
View article: Efficacy and Safety of Direct Oral Anticoagulants After Mechanical Thrombectomy in Venous Thromboembolism: A Comparative Study of 55 Patients
Efficacy and Safety of Direct Oral Anticoagulants After Mechanical Thrombectomy in Venous Thromboembolism: A Comparative Study of 55 Patients Open
BACKGROUND Inherited deficiencies in antithrombin (AT), protein C (PC), and protein S (PS) increase the risk of venous thromboembolism (VTE). The efficacy and safety of direct oral anticoagulants (DOACs) in severe VTE cases after mechanica…
View article: Impact of chronic kidney disease on left atrial appendage occlusion: A meta-analysis of procedural outcomes and complications
Impact of chronic kidney disease on left atrial appendage occlusion: A meta-analysis of procedural outcomes and complications Open
Background: Patients with chronic kidney disease (CKD) experience atrial fibrillation more frequently. The balance of medical management for stroke prevention and bleeding events presents a challenging issue in CKD population. Left atrial …
View article: Incidence, Risk Factors, and Outcomes of Left Atrial Enlargement in Patients Requiring Right Ventricular Pacing: A Retrospective Study of 461 Cases from 2012 to 2020
Incidence, Risk Factors, and Outcomes of Left Atrial Enlargement in Patients Requiring Right Ventricular Pacing: A Retrospective Study of 461 Cases from 2012 to 2020 Open
BACKGROUND Long-term right ventricular (RV) pacing has been linked to left atrial enlargement (LAE). The incidence and risk factors associated with significant LAE after RV pacing remain unknown. This retrospective study included 461 patie…
View article: Machine Learning-Based Prediction of Coronary Care Unit Readmission: A Multi-Hospital Validation Study
Machine Learning-Based Prediction of Coronary Care Unit Readmission: A Multi-Hospital Validation Study Open
Readmission to the Coronary Care Unit (CCU) has significant implications for patient outcomes and healthcare expenditure, emphasizing the urgency to accurately identify patients at high readmission risk. This study aims to construct and ex…
View article: One-Year Clinical Outcomes in Acute ST-Segment Elevation Myocardial Infarction Patients Undergoing Optical Coherence Tomography-Guided Primary Percutaneous Coronary Intervention: A Comparative Study.
One-Year Clinical Outcomes in Acute ST-Segment Elevation Myocardial Infarction Patients Undergoing Optical Coherence Tomography-Guided Primary Percutaneous Coronary Intervention: A Comparative Study. Open
BACKGROUND Percutaneous coronary intervention (PCI) with angiography guidance is a common procedure. Optical coherence tomography (OCT) is a non-invasive imaging method that uses light waves. This study from a single center aimed to compar…
View article: Effect of His Bundle Pacing on Abnormal Myocardial Fatty Acid and Glucose Metabolism Induced by Right Ventricular Pacing
Effect of His Bundle Pacing on Abnormal Myocardial Fatty Acid and Glucose Metabolism Induced by Right Ventricular Pacing Open
Background Metabolic disorder is noted for pacing‐induced cardiomyopathy. The benefits of His bundle pacing over right ventricular (RV) pacing in preventing pacing‐induced cardiomyopathy from a metabolic perspective are yet to be fully und…
View article: Machine learning-based prediction of coronary care unit readmission: A multihospital validation study
Machine learning-based prediction of coronary care unit readmission: A multihospital validation study Open
Objective Readmission to the coronary care unit (CCU) has significant implications for patient outcomes and healthcare expenditure, emphasizing the urgency to accurately identify patients at high readmission risk. This study aims to constr…
View article: Huge Left Atrial Myxoma Obstructs the Mitral Valve and Causes Massive Pleural Effusion
Huge Left Atrial Myxoma Obstructs the Mitral Valve and Causes Massive Pleural Effusion Open
View article: Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease–Related Pulmonary Arterial Hypertension
Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease–Related Pulmonary Arterial Hypertension Open
Background Pulmonary artery hypertension (PAH) is a fatal disease characterized by a complex pathogenesis. Exosomes containing microRNAs (miRs) have emerged as a novel biomarker. Transpulmonary exosomal miRs offer valuable insights into pu…
View article: Ivabradine could not decrease mitral regurgitation triggered atrial fibrosis and fibrillation compared with carvedilol
Ivabradine could not decrease mitral regurgitation triggered atrial fibrosis and fibrillation compared with carvedilol Open
Background Ivabradine, a medical treatment for heart failure (HF), reduces heart rate (HR) and prolongs diastolic perfusion time. It is frequently prescribed to patients with HF who have a suboptimal response or intolerance to beta‐blocker…
View article: Left bundle branch pacing preserved left ventricular myocardial work in patients with bradycardia
Left bundle branch pacing preserved left ventricular myocardial work in patients with bradycardia Open
Background Left bundle branch pacing (LBBP) is an emerging physiological pacing modality. Left ventricular (LV) myocardial work (MW) incorporates afterload and LV global longitudinal strain to estimate global and segmental myocardial contr…
View article: Downregulation of SIRT1 and GADD45G genes and left atrial fibrosis induced by right ventricular dependent pacing in a complete atrioventricular block pig model
Downregulation of SIRT1 and GADD45G genes and left atrial fibrosis induced by right ventricular dependent pacing in a complete atrioventricular block pig model Open
The molecular and genetic mechanisms underlying left atrial (LA) enlargement and atrial fibrosis following right ventricular (RV) dependent pacing remain unclear. Our objective was to investigate genetic expressions in the LA of pigs subje…
View article: Impact of Coexisting Risk Factors on Outcomes in Patients with Acute Coronary Syndrome: A Real-World Analysis Using the Taiwan Chang Gung Research Database
Impact of Coexisting Risk Factors on Outcomes in Patients with Acute Coronary Syndrome: A Real-World Analysis Using the Taiwan Chang Gung Research Database Open
BACKGROUND Diabetes mellitus (DM), chronic kidney disease (CKD), and advanced age are associated with poor outcomes in patients with acute coronary syndrome (ACS). This real-world study utilized data from the Taiwan Chang Gung Research Dat…
View article: Outcomes of catheter ablation vs. medical treatment for atrial fibrillation and heart failure: a meta-analysis
Outcomes of catheter ablation vs. medical treatment for atrial fibrillation and heart failure: a meta-analysis Open
Background The benefit of catheter ablation vs. medical treatment has been reported to be inconsistent in randomized controlled trials (RCTs) for patients with atrial fibrillation (AF) and heart failure (HF) due to different enrollment cri…
View article: Sodium-Glucose Cotransporter 2 Inhibitors First Strategy Improve Decongestion in Patients with Symptomatic Heart Failure and Reduced Ejection Fraction When Compared to Angiotensin Receptor Neprilysin Inhibitor First Strategy
Sodium-Glucose Cotransporter 2 Inhibitors First Strategy Improve Decongestion in Patients with Symptomatic Heart Failure and Reduced Ejection Fraction When Compared to Angiotensin Receptor Neprilysin Inhibitor First Strategy Open
Background: Angiotensin receptor neprilysin inhibitor (ARNI) and sodium-glucose cotransporter 2 inhibitor (SGLT2i) are emerging medical treatments for decompensated heart failure (HF) with reduced ejection fraction. In clinical practice, t…
View article: The Impact of Complete Revascularization in Symptomatic Severe Left Ventricular Dysfunction between Coronary Artery Bypass Graft and Percutaneous Coronary Intervention
The Impact of Complete Revascularization in Symptomatic Severe Left Ventricular Dysfunction between Coronary Artery Bypass Graft and Percutaneous Coronary Intervention Open
Objective. The study aimed to compare the clinical outcomes between the patients receiving coronary artery bypass surgery (CABG) or percutaneous coronary intervention (PCI) for the patients with symptomatic severe left ventricular (LV) dys…
View article: Sacubitril/valsartan improves all-cause mortality in heart failure patients with reduced ejection fraction and chronic kidney disease
Sacubitril/valsartan improves all-cause mortality in heart failure patients with reduced ejection fraction and chronic kidney disease Open
View article: Comparing Vitamin K Antagonists and Direct Oral Anticoagulants in Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement: A Meta-Analysis
Comparing Vitamin K Antagonists and Direct Oral Anticoagulants in Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement: A Meta-Analysis Open
Aortic stenosis (AS) is the most prevalent valvular disease in the elderly population and the prevalence of atrial fibrillation (AF) increases in the elderly population. Transcatheter aortic valve replacement (TAVR) becomes an important tr…
View article: Impact of baseline renal function on the efficacy and safety of different Anticoagulants in Atrial Fibrillation Patients – A cohort study
Impact of baseline renal function on the efficacy and safety of different Anticoagulants in Atrial Fibrillation Patients – A cohort study Open
View article: Coronary Artery Bypass Graft Surgery Brings Better Benefits to Heart Failure Hospitalization for Patients with Severe Coronary Artery Disease and Reduced Ejection Fraction
Coronary Artery Bypass Graft Surgery Brings Better Benefits to Heart Failure Hospitalization for Patients with Severe Coronary Artery Disease and Reduced Ejection Fraction Open
Objectives: We compared the outcomes between percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) for revascularization in patients with reduced ejection fraction (EF) and severe coronary artery disease …
View article: Levosimendan Administration May Provide More Benefit for Survival in Patients with Non-Ischemic Cardiomyopathy Experiencing Acute Decompensated Heart Failure
Levosimendan Administration May Provide More Benefit for Survival in Patients with Non-Ischemic Cardiomyopathy Experiencing Acute Decompensated Heart Failure Open
Background: Acute decompensated heart failure (ADHF) is a life-threatening condition with a high mortality rate. Levosimendan is an effective inotropic agent used to maintain cardiac output and a long-lasting effect. However, only few stud…