Zhi Wei Lim
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View article: Risk factors for diabetic ketoacidosis at first presentation of type 1 diabetes: an 8‐year (2015–2022) audit at an Australian regional hospital
Risk factors for diabetic ketoacidosis at first presentation of type 1 diabetes: an 8‐year (2015–2022) audit at an Australian regional hospital Open
Background Risk factors for diabetic ketoacidosis (DKA) at first presentation of type 1 diabetes (T1DM) have been investigated in a small number of studies, but further studies are required to better define them. In particular, a family hi…
Transcriptional regulation of autophagy in skeletal muscle stem cells Open
Muscle stem cells (MuSCs) are essential for the regenerative capabilities of skeletal muscles. MuSCs are maintained in a quiescent state, but, when activated, can undergo proliferation and differentiation into myocytes, which fuse and matu…
View article: Cellular Uptake of Phase‐Separating Peptide Coacervates (Adv. Sci. 42/2024)
Cellular Uptake of Phase‐Separating Peptide Coacervates (Adv. Sci. 42/2024) Open
Peptide Coacervates for Intracellular Therapeutic Delivery Peptide coacervate microdroplets (CMs) are promising vectors to deliver a broad range of macromolecular therapeutics inside cells, but the mechanism by which CMs enter cells has re…
View article: Cellular Uptake of Phase‐Separating Peptide Coacervates
Cellular Uptake of Phase‐Separating Peptide Coacervates Open
Peptide coacervates self‐assembling via liquid‐liquid phase separation are appealing intracellular delivery vehicles of macromolecular therapeutics (proteins, DNA, mRNA) owing to their non‐cytotoxicity, high encapsulation capacity, and eff…
View article: Cellular Uptake of His-Rich Peptide Coacervates Occurs by a Macropinocytosis-Like Mechanism
Cellular Uptake of His-Rich Peptide Coacervates Occurs by a Macropinocytosis-Like Mechanism Open
Coacervates are dense microdroplets formed by liquid-liquid phase separation (LLPS) of macromolecules that have gained increasing attention as drug delivery vehicles. Recently, we have reported a new intracellular delivery system based on …
Contents: Journal of the Chinese Chemical Society 4/2021 Open
In this paper, electron injection from lithium metal into a robust indole core and subsequent treatment with a boron electrophile result in boron insertion to yield an attractive BN-isostere of naphthalene.The lovely Jizo, located in Enkoj…
View article: Systematic review of imaging tests to predict the development of rheumatoid arthritis in people with unclassified arthritis
Systematic review of imaging tests to predict the development of rheumatoid arthritis in people with unclassified arthritis Open
Objectives To estimate and compare the diagnostic accuracy of magnetic resonance imaging (MRI) and ultrasound, for the prediction of rheumatoid arthritis (RA) in unclassified arthritis (UA). Methods MEDLINE, Embase and BIOSIS were searched…
Phase-Separating Peptides for Direct Cytosolic Delivery and Redox-Activated Release of Macromolecular Therapeutics. Open
Biomacromolecules are highly promising therapeutic modalities to treat various diseases. However, they suffer from poor cellular membrane permeability, limiting their access to intracellular targets. Strategies to overcome this challenge e…
Biomimetic coacervates for drug delivery Open
Biomimetics has provided inspirations to design innovative materials and advanced technologies. The squid beak of Dosidicus gigas, commonly known as Humboldt squid is a fascinating instance, being a “biotool” with remarkable gradient stiff…
Replication data for: Magnetically responsive peptide coacervates for dual hyperthermia and chemotherapy treatments of liver cancer Open
Liver cancer is an aggressive malignancy associated with high levels of mortality and morbidity. Doxorubicin (Dox) is often used to slow down liver cancer progression; however its efficacy is limited, and its severe side effects prevent it…
Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish Open
Aims A robust inflammatory response to tissue injury is a necessary part of the repair process but the deposition of scar tissue is a direct downstream consequence of this response in many tissues including the heart. Adult zebrafish not o…
The seahorse genome and the evolution of its specialized morphology Open
Seahorses have a specialized morphology that includes a toothless tubular mouth, a body covered with bony plates, a male brood pouch, and the absence of caudal and pelvic fins. Here we report the sequencing and de novo assembly of the geno…
The effect of systemic inflammation on human brain barrier function Open
The blood-brain barrier (BBB) plays an important role in the clinical expression of neuropsychiatric symptoms during systemic illness in health and neurological disease. Evidence from in vitro and preclinical in vivo studies indicate that …
Lymphopenia in treatment-naive relapsing multiple sclerosis Open
Lymphopenia accompanies some autoimmune diseases. A number of studies, but not others, have suggested that lymphopenia occurs in treatment-naive multiple sclerosis (MS), so the issue remains unresolved. This is important since lymphopenia …