Wei Zheng
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View article: Association of community-level deprivation with breast cancer risk and survival among women residing in the southeastern United States
Association of community-level deprivation with breast cancer risk and survival among women residing in the southeastern United States Open
Background Studies on the association of community-level deprivation indices with breast cancer risk and survival after breast cancer diagnosis have yielded mixed results, and few have included large enough samples of low-income and ethnic…
View article: Moutan Cortex: A Review of Origins, Phytochemical Characterization Strategies, and Anti-fibrosis-related Pharmacological Mechanisms and Applications
Moutan Cortex: A Review of Origins, Phytochemical Characterization Strategies, and Anti-fibrosis-related Pharmacological Mechanisms and Applications Open
Traditional medicine has long acknowledged the therapeutic effects of Moutan cortex (MC), derived from the dried root bark of the tree peony. In recent times, scientific investigations have shed light on its bioactive components and the me…
View article: Reactivation of Human X-Linked Gene and Stable X-Chromosome Inactivation Observed in Generation and Differentiation of iPSCs from a Female Patient with HNRNPH2 Mutation
Reactivation of Human X-Linked Gene and Stable X-Chromosome Inactivation Observed in Generation and Differentiation of iPSCs from a Female Patient with HNRNPH2 Mutation Open
X chromosome inactivation (XCI) is a fundamental epigenetic process that balances X-linked gene expression between females and males by silencing one X chromosome in female cells. Variability or skewing of XCI can influence the clinical pr…
View article: Stimuli-responsive antimicrobial polymer systems: From structural design to biomedical applications
Stimuli-responsive antimicrobial polymer systems: From structural design to biomedical applications Open
Bacterial infections and drug-resistant evolution have seriously threatened public health. Stimuli-responsive antimicrobial materials have been rapidly developed to address the evolving challenges posed by multi-drug-resistant bacteria. Am…
View article: The silent threat: effects of PM2.5 exposure on perinatal complications and neonatal outcomes
The silent threat: effects of PM2.5 exposure on perinatal complications and neonatal outcomes Open
The exposure level of PM2.5 is significantly correlated with an increased incidence of gestational hypertension and a decrease in birth weight, it is essential for obstetricians to incorporate air quality considerations into the framework …
View article: Underlining the Molecular Mechanism of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in Lipid Metabolism by Combining Multiple Sets of Data Sets
Underlining the Molecular Mechanism of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in Lipid Metabolism by Combining Multiple Sets of Data Sets Open
Nonalcoholic fatty liver disease (NAFLD) is closely associated with coronary artery disease (CAD); however, their shared genetic traits and molecular mechanisms in lipid metabolism remain unclear. In this study, we identified that the diff…
View article: Damage behavior of aircraft radome under high-speed jet impact
Damage behavior of aircraft radome under high-speed jet impact Open
View article: <scp>CircMAN1A2</scp> Levels Determine <scp>GBM</scp> Susceptibility to <scp>TMZ</scp> in a Pathway Involving <scp>TEP1‐</scp> and <scp>KEAP1</scp>‐Mediated <scp>NRF2</scp> Degradation Leading to Ferroptosis
<span>CircMAN1A2</span> Levels Determine <span>GBM</span> Susceptibility to <span>TMZ</span> in a Pathway Involving <span>TEP1‐</span> and <span>KEAP1</span>‐Mediated <span>NRF2</span> Degradation Leading to Ferroptosis Open
Background Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis and resistance to temozolomide (TMZ). The role of downregulated circular RNAs (circRNAs) in GBM progression remains unclear. Methods CircRNA sequencing an…
View article: An Integrated Platform for High-Throughput Extraction and Mass Spectrometry-Based Quantification of Cholesterol and Sphingosine
An Integrated Platform for High-Throughput Extraction and Mass Spectrometry-Based Quantification of Cholesterol and Sphingosine Open
Quantification of cellular lipids in a reproducible and high-throughput manner is a key step in the development of therapeutics for lipid storage diseases. Niemann-Pick Disease Type C (NPC) is a genetic disorder characterized by the accumu…
View article: Leveraging viral genome sequences and machine learning models for identification of potentially selective antiviral agents
Leveraging viral genome sequences and machine learning models for identification of potentially selective antiviral agents Open
Viral genome sequencing provides valuable information for antiviral development, yet its integration with machine learning for virtual screening remains underexplored. To bridge this gap, viral genome sequences were combined with structura…
View article: Reliability and sensitivity analysis of honeycomb sandwich composite radome structure
Reliability and sensitivity analysis of honeycomb sandwich composite radome structure Open
Radome is an important structural component for protecting an aircraft′s radar antenna and is usually located in the nose part of the aircraft. A method for evaluating the reliability and sensitivity of a honeycomb sandwich composite radom…
View article: Environmental pollution and human fertility: investigating the relationship between PM2.5 exposure and assisted reproductive technology outcomes
Environmental pollution and human fertility: investigating the relationship between PM2.5 exposure and assisted reproductive technology outcomes Open
View article: Multifunctional Natural Herbal Extracts Liposomal Loaded Hybrid Hydrogel for Skin Improvement and Repair
Multifunctional Natural Herbal Extracts Liposomal Loaded Hybrid Hydrogel for Skin Improvement and Repair Open
Background: Hydrogel dressings have the advantages of continuous moisturizing, good permeability, antibacterial and biocompatibility, and can be used as an expecting material for skin improvement and protection. Among natural herbal extrac…
View article: Genetically Predicted Gene Expression Effects on Changes in Red Blood Cell and Plasma Polyunsaturated Fatty Acids
Genetically Predicted Gene Expression Effects on Changes in Red Blood Cell and Plasma Polyunsaturated Fatty Acids Open
Polyunsaturated fatty acids (PUFAs) including omega‐3 and omega‐6 are obtained from diet and can be measured objectively in plasma or red blood cells (RBCs) membrane biomarkers, representing different dietary exposure windows. In vivo conv…
View article: Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression Open
Psoriasis is an incurable chronic inflammatory disease that requires new interventions. Here, we found that fibroblasts exacerbate psoriasis progression by promoting macrophage recruitment via CCL2 secretion by single-cell multi-omi…
View article: Unlocking Unit-Based Instruction: Teachers’ Voices on Bridging China's Curriculum Reform with Junior High English Classrooms
Unlocking Unit-Based Instruction: Teachers’ Voices on Bridging China's Curriculum Reform with Junior High English Classrooms Open
View article: Vs-Smote: Leveraging High-Value Spaces to Balance Noise Control and Data Diversity for Class-Imbalanced Learning
Vs-Smote: Leveraging High-Value Spaces to Balance Noise Control and Data Diversity for Class-Imbalanced Learning Open
View article: Dynamic Damage Behavior of Aircraft Skin Coating Impacted by High-Velocity Water Jet
Dynamic Damage Behavior of Aircraft Skin Coating Impacted by High-Velocity Water Jet Open
View article: Molecular Mechanism of hsa-circKLK3-25 in Regulating Prostate Cancer Progression via the JNK/ERK Signal Transduction Pathway
Molecular Mechanism of hsa-circKLK3-25 in Regulating Prostate Cancer Progression via the JNK/ERK Signal Transduction Pathway Open
Background: PCa (representing prostate cancer) ranks among the most prevalent malignancies in males. This disease begins insidiously. Most patients have reached an advanced stage when being diagnosed for the first time. Moreover, this cond…
View article: Identifying Preferred Features of Influenza Vaccination Programs Among Chinese Clinicians Practicing Traditional Chinese Medicine and Western Medicine: Discrete Choice Experiment
Identifying Preferred Features of Influenza Vaccination Programs Among Chinese Clinicians Practicing Traditional Chinese Medicine and Western Medicine: Discrete Choice Experiment Open
Background Achieving high vaccine coverage among clinicians is crucial to curb the spread of influenza. Traditional Chinese medicine (TCM), rooted in cultural symbols and concepts without direct parallels in modern Western medicine, may in…
View article: Generation of induced pluripotent stem cell lines TRNDi037-A and TRNDi038-A from two patients with Alagille syndrome carrying heterozygous JAG1 mutations
Generation of induced pluripotent stem cell lines TRNDi037-A and TRNDi038-A from two patients with Alagille syndrome carrying heterozygous JAG1 mutations Open
Human induced pluripotent stem cell (iPSC) lines TRNDi037-A and TRNDi038-A were generated from the lymphoblastoid cell lines (LCL) of two patients with different heterozygous JAG1 variants resulting in Alagille syndrome (ALGS). ALGS is a r…
View article: Repurposing of lonafarnib as a treatment for SARS-CoV-2 infection
Repurposing of lonafarnib as a treatment for SARS-CoV-2 infection Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a global pandemic pathogen with high mortality. While treatments have been developed to reduce morbidity and mor…
View article: Generation of an induced pluripotent stem cell line (TRNDi042-A) from a Mucopolysaccharidosis type IIIB patient with homozygous p. R626X (c. 1876C > T) mutation in the NAGLU gene
Generation of an induced pluripotent stem cell line (TRNDi042-A) from a Mucopolysaccharidosis type IIIB patient with homozygous p. R626X (c. 1876C > T) mutation in the NAGLU gene Open
View article: Therapeutic development approaches to treat haploinsufficiency diseases: restoring protein levels
Therapeutic development approaches to treat haploinsufficiency diseases: restoring protein levels Open
Rare diseases affect one in ten people but only a small fraction of these diseases have an FDA-approved treatment. Haploinsufficiency, caused by a dominant loss-of-function mutation, is a unique rare disease group because patients have one…
View article: Six induced pluripotent stem cell lines from fibroblasts of individuals with CLN3-related conditions
Six induced pluripotent stem cell lines from fibroblasts of individuals with CLN3-related conditions Open
Primary fibroblasts from six individuals with CLN3-related conditions were used to generate induced pluripotent stem cell (iPSC) lines CHDTRi001-B, CHDTRi002-B, CHDTRi003-A, CHDTRi004-B, CHDTRi005-A, and CHDTRi006-E through the expression …
View article: Tilorone mitigates the propagation of α-synucleinopathy in a midbrain-like organoid model
Tilorone mitigates the propagation of α-synucleinopathy in a midbrain-like organoid model Open
Background Parkinson’s disease (PD) is a neurodegenerative condition characterized by the loss of dopaminergic neurons and the accumulation of Lewy-body protein aggregates containing misfolded α-synuclein (α-syn) in a phosphorylated form. …
View article: Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai, China
Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai, China Open
View article: Identification of Potent ADCK3 Inhibitors through Structure-Based Virtual Screening
Identification of Potent ADCK3 Inhibitors through Structure-Based Virtual Screening Open
ADCK3 is a member of the UbiB family of atypical protein kinases in humans, with homologues in archaea, bacteria, and eukaryotes. In lieu of protein kinase activity, ADCK3 plays a role in the biosynthesis of coenzyme Q10 (CoQ10), and inact…
View article: Ferroptosis: a novel mechanism of cell death in ophthalmic conditions
Ferroptosis: a novel mechanism of cell death in ophthalmic conditions Open
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and aut…
View article: Identifying preferred features of influenza vaccination programs among clinicians practicing traditional Chinese medicine and western medicine: A discrete choice experiment (Preprint)
Identifying preferred features of influenza vaccination programs among clinicians practicing traditional Chinese medicine and western medicine: A discrete choice experiment (Preprint) Open
BACKGROUND The preferences for features of influenza vaccination programs among clinicians practicing traditional Chinese medicine (TCM) and modern western medicine (WM) remained unknown. OBJECTIVE To understand preferences for features…