Wei Zou
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View article: Dynamic properties of transcriptional condensates modulate CRISPRa-mediated gene activation
Dynamic properties of transcriptional condensates modulate CRISPRa-mediated gene activation Open
CRISPR activation (CRISPRa) is a powerful tool for endogenous gene activation, yet the mechanisms underlying its optimal transcriptional activation remain unclear. By monitoring real-time transcriptional bursts, we find that CRISPRa modula…
View article: Endocytosis restricts dendrite branching via removing ectopically localized branching ligands
Endocytosis restricts dendrite branching via removing ectopically localized branching ligands Open
View article: MONITTR allows real-time imaging of transcription and endogenous proteins in <i>C. elegans</i>
MONITTR allows real-time imaging of transcription and endogenous proteins in <i>C. elegans</i> Open
Maximizing cell survival under stress requires rapid and transient adjustments of RNA and protein synthesis. However, capturing these dynamic changes at both single-cell level and across an organism has been challenging. Here, we developed…
View article: Analysis of the Baijiu Pit Mud Microorganisms and Sub-Communities that Biosynthesize Specific Metabolites, Using Genomic and Metabolic Models
Analysis of the Baijiu Pit Mud Microorganisms and Sub-Communities that Biosynthesize Specific Metabolites, Using Genomic and Metabolic Models Open
View article: MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity
MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity Open
Transcription factors (TFs) play critical roles in specifying many aspects of neuronal cell fate including dendritic morphology. How TFs are accurately regulated during neuronal morphogenesis is not fully understood. Here, we show that LIM…
View article: Ribo-On and Ribo-Off tools using a self-cleaving ribozyme allow manipulation of endogenous gene expression in C. elegans
Ribo-On and Ribo-Off tools using a self-cleaving ribozyme allow manipulation of endogenous gene expression in C. elegans Open
View article: Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila
Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila Open
View article: Two-Color CRISPR Imaging Reveals Dynamics of Herpes Simplex Virus 1 Replication Compartments and Virus-Host Interactions
Two-Color CRISPR Imaging Reveals Dynamics of Herpes Simplex Virus 1 Replication Compartments and Virus-Host Interactions Open
Herpes simplex virus 1 (HSV-1), a representative of the family Herpesviridae , is a ubiquitous pathogen that can establish lifelong infections and widely affects human health. Viral infection is a dynamic process that involves many steps a…
View article: Gene activation guided by nascent RNA-bound transcription factors
Gene activation guided by nascent RNA-bound transcription factors Open
View article: Real-time imaging of RNA polymerase I activity in living human cells
Real-time imaging of RNA polymerase I activity in living human cells Open
RNA polymerase I (Pol I) synthesizes about 60% of cellular RNA by transcribing multiple copies of the ribosomal RNA gene (rDNA). The transcriptional activity of Pol I controls the level of ribosome biogenesis and cell growth. However, ther…
View article: The cell cortex-localized protein CHDP-1 is required for dendritic development and transport in C. elegans neurons
The cell cortex-localized protein CHDP-1 is required for dendritic development and transport in C. elegans neurons Open
Cortical actin, a thin layer of actin network underneath the plasma membranes, plays critical roles in numerous processes, such as cell morphogenesis and migration. Neurons often grow highly branched dendrite morphologies, which is crucial…
View article: Research progress of live-cell RNA imaging techniques
Research progress of live-cell RNA imaging techniques Open
RNA molecules play diverse roles in many physiological and pathological processes as they interact with various nucleic acids and proteins. The various biological processes of RNA are highly dynamic. Tracking RNA dynamics in living cells i…
View article: <i>Toxoplasma gondii</i> SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity
<i>Toxoplasma gondii</i> SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity Open
View article: TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cells
TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cells Open
A wealth of single-cell imaging studies have contributed novel insights into chromatin organization and gene regulation. However, a comprehensive understanding of spatiotemporal gene regulation requires developing tools to combine multiple…
View article: An Endoplasmic Reticulum ATPase Safeguards Endoplasmic Reticulum Identity by Removing Ectopically Localized Mitochondrial Proteins
An Endoplasmic Reticulum ATPase Safeguards Endoplasmic Reticulum Identity by Removing Ectopically Localized Mitochondrial Proteins Open
Stringent targeting of membrane proteins to corresponding organelles is essential for organelle identity and functions. In addition to molecular pathways that target proteins to appropriate organelles, surveillance mechanisms clear mistarg…
View article: TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cells
TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cells Open
A wealth of single-cell imaging studies have contributed novel insights into chromatin organization and gene regulation. However, a comprehensive understanding of spatiotemporal gene regulation requires developing tools to combine multiple…
View article: An endoplasmic reticulum (ER) ATPase safeguards ER identity by removing ectopically localized mitochondrial proteins
An endoplasmic reticulum (ER) ATPase safeguards ER identity by removing ectopically localized mitochondrial proteins Open
SUMMARY Stringent targeting of membrane proteins to corresponding organelles is essential for organelle identity and functions. In addition to molecular pathways that target proteins to appropriate organelles, surveillance mechanisms clear…
View article: [Intrinsic and extrinsic mechanisms regulating neuronal dendrite morphogenesis].
[Intrinsic and extrinsic mechanisms regulating neuronal dendrite morphogenesis]. Open
Neurons are the structural and functional unit of the nervous system. Precisely regulated dendrite morphogenesis is the basis of neural circuit assembly. Numerous studies have been conducted to explore the regulatory mechanisms of dendriti…
View article: Evaluating cybersecurity risks in the maritime industry: a literature review
Evaluating cybersecurity risks in the maritime industry: a literature review Open
Cybersecurity has become an important issue in the maritime industry due to many reported cyberattack incidents that caused a lot of economy loss, personal or company information breach, and so on. However, there is limited research for ma…
View article: Mitophagy, a potential therapeutic target for stroke
Mitophagy, a potential therapeutic target for stroke Open
View article: Efficient labeling and imaging of protein-coding genes in living cells using CRISPR-Tag
Efficient labeling and imaging of protein-coding genes in living cells using CRISPR-Tag Open
View article: Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development
Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development Open
Ribosome degradation through the autophagy-lysosome pathway is crucial for cell survival during nutrient starvation, but whether it occurs under normal growth conditions and contributes to animal physiology remains unaddressed. In this stu…
View article: Author response: Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development
Author response: Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development Open
View article: A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching
A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching Open
View article: CRISPR-Tag: an Efficient DNA Tagging System in Living Cells
CRISPR-Tag: an Efficient DNA Tagging System in Living Cells Open
Main text A lack of efficient tools to image non-repetitive genes in living cells has limited our ability to explore the functional impact of spatiotemporal dynamics of genes. Here, we addressed this issue by developing the CRISPR-Tag syst…
View article: Acupuncture through Baihui (DU20) to Qubin (GB7) mitigates neurological impairment after intracerebral hemorrhage
Acupuncture through Baihui (DU20) to Qubin (GB7) mitigates neurological impairment after intracerebral hemorrhage Open
Inflammation plays an important role in nerve defects caused by intracerebral hemorrhage. Repairing brain damage by inhibiting the macrophage-inducible C-type lectin/spleen tyrosine kinase (Mincle/Syk) signaling pathway is a potential new …
View article: [Percutaneous pedicle screw fixation and minimally invasive decompression in the same incision for type A3 thoracolumbar burst fracture].
[Percutaneous pedicle screw fixation and minimally invasive decompression in the same incision for type A3 thoracolumbar burst fracture]. Open
Percutaneous pedicle screw fixation and minimally invasive decompression in the same incision for type A3 thoracolumbar burst fracture has satisfactory effectiveness. And it has the advantages of minimal trauma, quick recovery, safeness, a…
View article: The NS1 TAD2 domain is responsible for transactivation of various cell cycle related genes.
The NS1 TAD2 domain is responsible for transactivation of various cell cycle related genes. Open
NS1-S1 and NS1mTAD2-S1 cells were induced by Dox (5 μg/ml) for 72 h. The cells were then collected, lysed, and immunoblotted with the indicated antibodies in each panel (A-E). S1 cells and S1 cells treated with Noco or HU were l…
View article: [Design and clinical application of a new extracorporeal reduction device for percutaneous pedicle screw fixation in treatment of thoracolumbar fractures].
[Design and clinical application of a new extracorporeal reduction device for percutaneous pedicle screw fixation in treatment of thoracolumbar fractures]. Open
Minimally invasive extracorporeal reduction device for percutaneous pedicle screw fixation is an effective and safe treatment of thoracic vertebrae and lumbar vertebrae fractures, because of little trauma, less bleeding, and quicker recove…
View article: Autophagy, endoplasmic reticulum stress and the unfolded protein response in intracerebral hemorrhage
Autophagy, endoplasmic reticulum stress and the unfolded protein response in intracerebral hemorrhage Open
Intracerebral hemorrhage (ICH) is a subtype of stroke that is followed by primary and secondary brain injury. As a result of the injury, cell metabolism is disrupted and a series of stress responses are activated, such as endoplasmic retic…