Ho‐Chang Kuo
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View article: Structure and Nitrite Reductase Activity of the Di-iron Protein ScdA in <i>Staphylococcus aureus</i>
Structure and Nitrite Reductase Activity of the Di-iron Protein ScdA in <i>Staphylococcus aureus</i> Open
Pathogenic Staphylococcus aureus endures bursts of host-derived reactive nitrogen species, yet the molecular defenses that enable this resilience have remained unclear. We now show that the previously enigmatic di-iron enzyme ScdA function…
View article: Clinical impact of pharmacogenetic risk variants in a large chinese cohort
Clinical impact of pharmacogenetic risk variants in a large chinese cohort Open
Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcomes by optimizing drug selection and dosage based on genetic factors affecting drug response. A key advantage of PGx-guided therapy is to decrease t…
View article: <i>Eggerthella lenta</i> down regulated flavone and flavonol biosynthesis promoted Kawasaki disease
<i>Eggerthella lenta</i> down regulated flavone and flavonol biosynthesis promoted Kawasaki disease Open
Kawasaki Disease (KD) is a multisystemic vasculitis of unknown aetiology in children. The incidence of KD varies by geographic area and correlates with differences in gut microbiota patterns, with the highest incidence in Asian. This study…
View article: Intravenous Immunoglobulin Alone for Coronary Artery Lesion Treatment of Kawasaki Disease
Intravenous Immunoglobulin Alone for Coronary Artery Lesion Treatment of Kawasaki Disease Open
Importance Aspirin (acetylsalicylic acid) and intravenous immunoglobulin (IVIG) are standard treatments for Kawasaki disease (KD) to reduce coronary artery lesions (CALs). However, the optimal duration and dosage of aspirin remain inconsis…
View article: Association of Kawasaki disease with intellectual disability, attention deficit hyperactivity disorder, and autism spectrum disorder: a systematic review and meta-analysis
Association of Kawasaki disease with intellectual disability, attention deficit hyperactivity disorder, and autism spectrum disorder: a systematic review and meta-analysis Open
Background The relationship between Kawasaki disease (KD) and neurodevelopmental disorders (NDDs) remains unclear. This study aims to explore the association between them. Method A systematic review was conducted using PubMed and Embase da…
View article: Tailored Predictive Indicators for Weaning Success from High-Flow Nasal Cannula in Postoperative Hypoxemic Patients
Tailored Predictive Indicators for Weaning Success from High-Flow Nasal Cannula in Postoperative Hypoxemic Patients Open
The use of high-flow nasal cannula (HFNC) as an oxygen therapy post-extubation has demonstrated varying success rates across different surgical populations. This study aimed to identify the predictive factors influencing HFNC weaning outco…
View article: Argonaute2 and Argonaute4 Involved in the Pathogenesis of Kawasaki Disease via mRNA Expression Profiles
Argonaute2 and Argonaute4 Involved in the Pathogenesis of Kawasaki Disease via mRNA Expression Profiles Open
Background: Argonautes (AGOs) are a type of protein that degrade specific messenger RNAs, consequently reducing the expression of a specific gene. These proteins consist of small, single-stranded RNA or DNA and may provide a route for dete…
View article: Identifying the risk of Kawasaki disease based solely on routine blood test features through novel construction of machine learning models
Identifying the risk of Kawasaki disease based solely on routine blood test features through novel construction of machine learning models Open
Kawasaki disease (KD) is a leading cause of acquired coronary vasculitis in children and remains a critical diagnostic challenge among febrile pediatric patients. To support frontline pediatricians with a more objective diagnostic tool, we…
View article: Neutralizing antibodies against SARS-CoV-2 of vaccinated healthcare workers in Taiwan
Neutralizing antibodies against SARS-CoV-2 of vaccinated healthcare workers in Taiwan Open
Heterologous prime-boost vaccines (AZD1222 + mRNA-1273) and two doses of mRNA vaccines are recommended. For future directions, we need to investigate the effectiveness of the vaccination against new SARS-CoV-2 variants.
View article: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Open
Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response1. One of the most promising bene…
View article: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Open
Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response 1 . One of the most promising be…
View article: High eosinophil counts aid in diagnosing Kawasaki disease in febrile children
High eosinophil counts aid in diagnosing Kawasaki disease in febrile children Open
Background Several recent studies have validated the newfound significance of elevated eosinophils in Kawasaki disease (KD). However, this finding was not incorporated into the suggested laboratory criteria outlined by the Kawasaki Disease…
View article: Association of Kawasaki disease with intellectual disability, attention deficit hyperactivity disorder, and autism spectrum disorder: a systematic review and meta-analysis
Association of Kawasaki disease with intellectual disability, attention deficit hyperactivity disorder, and autism spectrum disorder: a systematic review and meta-analysis Open
Background: The relationship between Kawasaki disease (KD) and neurodevelopmental disorders (NDDs) remains unclear. This study aims to explore the association between them. Method: A systematic review was conducted using PubMed and Embase …
View article: Risks of Kawasaki disease and multisystem inflammatory syndrome in pediatric patients with COVID-19 infection: A TriNetX based cohort study
Risks of Kawasaki disease and multisystem inflammatory syndrome in pediatric patients with COVID-19 infection: A TriNetX based cohort study Open
Background: The associations of coronavirus disease (COVID-19) with Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) remain unclear. Few large-scale studies have estimated the cumulative incidence of MIS-C an…
View article: Add-On Bifidobacterium Bifidum Supplement in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial
Add-On Bifidobacterium Bifidum Supplement in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial Open
We conducted a 12-week randomized double-blind placebo-controlled clinical trial to investigate the potential impact of Bifidobacterium bifidum (Bf-688) supplementation on attention-deficit/hyperactivity disorder (ADHD). Children with ADHD…
View article: EFFICACY OF INTRAVENOUS IMMUNOGLOBULIN ALONE ON CORONARY ARTERY LESION REDUCTION IN KAWASAKI DISEASE
EFFICACY OF INTRAVENOUS IMMUNOGLOBULIN ALONE ON CORONARY ARTERY LESION REDUCTION IN KAWASAKI DISEASE Open
Background Though Aspirin and intravenous immunoglobulin (IVIG) remain the standard treatments for Kawasaki Disease (KD) to minimize coronary artery damage, the duration and dosage of aspirin are inconsistent across hospitals. However, the…
View article: Time course of mice-model Kawasaki Disease An echocardiographic study and clinical implication
Time course of mice-model Kawasaki Disease An echocardiographic study and clinical implication Open
Background: Kawasaki disease is a primary cause of pediatric cardiac issues, with the risk of coronary artery complications, heart attacks, and untreated death. Approximately 10% of patients do not respond to initial high dose intravenous …
View article: Hydrogen Gas Inhalation Treatment for Coronary Artery Lesions in a Kawasaki Disease Mouse Model
Hydrogen Gas Inhalation Treatment for Coronary Artery Lesions in a Kawasaki Disease Mouse Model Open
Background: Kawasaki disease (KD) is a syndrome primarily affecting young children, typically under the age of five, and is characterized by the development of acute vasculitis. Through extensive research conducted on both murine and human…
View article: The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease
The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease Open
Background and Objectives: Recent studies suggest that hydrogen gas possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. This study aimed to explore the therapeutic potential of hydrogen gas and assess its safety and to…
View article: Positive Echocardiographic Association between Carotid Artery and Coronary Artery Diameter and Z-Score in a Mouse Model of Kawasaki Disease
Positive Echocardiographic Association between Carotid Artery and Coronary Artery Diameter and Z-Score in a Mouse Model of Kawasaki Disease Open
Kawasaki disease (KD) occurs in young children, has an unknown etiology, and can cause such life-threatening complications as coronary artery aneurysm. A mouse model using Lactobacillus casei cell wall extract (LCWE) with intraperitoneal i…
View article: Echocardiography and laboratory outcomes of COVID-19 in children with a history of Kawasaki disease: a preliminary observation
Echocardiography and laboratory outcomes of COVID-19 in children with a history of Kawasaki disease: a preliminary observation Open
Background Infection with SARS-CoV-2 virus has been associated with cardiovascular sequelae including multisystem inflammatory syndrome (MIS-C) in children. Patients with a prior history of Kawasaki disease, may be more susceptible to chan…
View article: Kawasaki Disease, MIS-C and COVID-19
Kawasaki Disease, MIS-C and COVID-19 Open
Kawasaki disease (KD) is a form of systemic vasculitis characterized by inflammation of blood vessels throughout the body, and its exact cause remains unknown [...]
View article: Diagnosis, Progress, and Treatment Update of Kawasaki Disease
Diagnosis, Progress, and Treatment Update of Kawasaki Disease Open
Kawasaki disease (KD) is an acute inflammatory disorder that primarily affects children and can lead to coronary artery lesions (CAL) if not diagnosed and treated promptly. The original clinical criteria for diagnosing KD were reported by …
View article: Smoking cessation and influenza vaccination can reduce the healthcare burden of COPD
Smoking cessation and influenza vaccination can reduce the healthcare burden of COPD Open
Combined smoking cessation and influenza vaccination are more effective in reducing the medical burden of COPD compared to either intervention alone or neither. These findings highlight the importance of promoting both smoking cessation an…
View article: Diagnosis Progress and Treatment Update of Kawasaki Disease
Diagnosis Progress and Treatment Update of Kawasaki Disease Open
Since first described by Dr. Tomisaku Kawasaki in 1967, the clinical diagnosis of Kawasaki disease (KD) has remained relatively unchanged. However, studies since then have suggested that diagnoses using only that original clinical criteria…
View article: Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort
Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort Open
Background Acute coronary syndrome (ACS) in early adulthood (<40 years old) may be associated with unrevealed diagnoses of Kawasaki disease (KD) in childhood. Daniels et al. showed that 5% of young adults with acute coronary syndrome mi…
View article: Basophils Predict Mite Sensitization in Patients with Kawasaki Disease
Basophils Predict Mite Sensitization in Patients with Kawasaki Disease Open
Background: Patients with Kawasaki disease (KD) are at a significantly increased risk of allergic diseases. Immunoglobulin E (IgE) is an immunoglobulin that mediates allergic sensitization to various allergens and is related to various all…