Explanipedia

Evaluating research mobility placements: a skills audit framework for enhancing employability and professional development in higher education Open

Fong-Lee Ng, Wei Hsum Yap, Phelim Voon Chen Yong · 2025

Higher education students benefit from research mobility placements, which provide authentic research experiences, opportunities for inter-institutional collaboration, and valuable employability skills. Despite their increasing importance,…

Implementation Outcomes of Reusable Learning Objects in Health Care Education Across Three Malaysian Universities: Evaluation Using the RE-AIM Framework Open

Hooi Min Lim, Chin Hai Teo, Yew Kong Lee, Ping Yein Lee, Kuhan Krishnan , et al. · 2025

Background Current e- learning evaluation focuses on learners’ knowledge gain, satisfaction, perceptions, and attitudes; few assess the implementation outcomes of e- learning resources in teaching and learning. Objective In this study, we …

In vivo retinoid metabolic and visual cycle pathways assessment of carotenoid-rich refined red palm-pressed mesocarp olein Open

Ying Hua Jin, Soek Sin Teh, Wei Hsum Yap, Harrison Lik Nang Lau, Siau Hui Mah · 2024

The Palm-pressed mesocarp is a by-product from the palm oil mill and is comprised of 5–7 % of residual oil, which could be further refined into red palm-pressed mesocarp olein (PPMO). This study aimed to obtain the chemical profile of PPMO…

Nrf2 Connects Cellular Autophagy and Vascular Senescence in Atherosclerosis: A Mini-Review Open

Kai Wen Wai, Liang Ee Low, Bey Hing Goh, Wei Hsum Yap · 2024

Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcriptional factor that maintains intracellular redox equilibrium, modulates the expression of antioxidant genes, scavenger receptors, and cholesterol efflux transporters, all of wh…

Prebiotic properties of germinated riceberry rice (Oryza sativa L.) fermented with Pleurotus ostreatus Open

Nattapol Rattanachart, Wei Hsum Yap, Amorn Owatworakit, Jutamat Nacha, Sunita Chamyuang · 2024

Editorial: Biofunctional Molecule Exploratory Research on Application in Food and Health Open

Wei Hsum Yap, Bey Hing Goh · 2023

Biofunctional molecules with pharmacological activities are reported in various fields of application, including in the pharmaceutical, cosmetics, nutraceuticals, agriculture, and food industries [...]

Editorial: The genetics of human Mendelian skin disorders Open

Wei Hsum Yap, Jia Zhang, Ming Li, Yiran Guo · 2022

EDITORIAL article Front. Genet., 01 December 2022Sec. Genetics of Common and Rare Diseases Volume 13 - 2022 | https://doi.org/10.3389/fgene.2022.1061724

Targeting Immune Senescence in Atherosclerosis Open

Danusha Michelle Vellasamy, Sin-Jye Lee, Khang Wen Goh, Bey Hing Goh, Yin-Quan Tang , et al. · 2022

Atherosclerosis is one of the main underlying causes of cardiovascular diseases (CVD). It is associated with chronic inflammation and intimal thickening as well as the involvement of multiple cell types including immune cells. The engageme…

Integrated Assessment of Macrophage Lipids Homeostasis Omics Data: Identification of Potential Genes and Pathways in Atherosclerosis Open

Wei Sheng Siew, Yin-Quan Tang, Wei Hsum Yap · 2022

Atherosclerosis is a chronic inflammatory disease characterized by the formation of lipid-rich plaques within the arterial wall. Increasing evidences have shown that cellular senescence may contribute to the progression of atherosclerosis,…

Knowledge transfer of eLearning objects: Lessons learned from an intercontinental capacity building project Open

Hooi Min Lim, Chirk Jenn Ng, Heather Wharrad, Yew Kong Lee, Chin Hai Teo , et al. · 2022

Background Effective knowledge transfer of eLearning objects can hasten the adoption and dissemination of technology in teaching and learning. However, challenges exist which hinder inter-organisational knowledge transfer, particularly acr…

Uncovering incontinentia pigmenti: From DNA sequence to pathophysiology Open

Kang Nien How, Hazel Jing Yi Leong, Zacharias Aloysius Dwi Pramono, Kin Fon Leong, Zee Wei Lai , et al. · 2022

Incontinentia pigmenti (IP) is an X-linked dominant genodermatosis. The disease is known to be caused by recurrent deletion of exons 4–10 of the Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma ( IKBKG) gene located at t…

Sophorolipids—Bio-Based Antimicrobial Formulating Agents for Applications in Food and Health Open

Wei Yan Cho, Jeck Fei Ng, Wei Hsum Yap, Bey Hing Goh · 2022

Sophorolipids are well-known glycolipid biosurfactants, produced mainly by non-pathogenic yeast species such as Candida bombicola with high yield. Its unique environmental compatibility and high biodegradable properties have made them a fo…

246P DNA repair protein RAD51 homolog 1 (RAD51), a potential prognostic biomarker and target for breast cancer Open

Yin-Quan Tang, Wei Hsum Yap, Adeline Yoke Yin Chia · 2022

Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin’s Circadian Rhythm Open

Camille Keisha Mahendra, Hooi‐Leng Ser, Priyia Pusparajah, Thet Thet Htar, Lay‐Hong Chuah , et al. · 2022

Sunlight is an important factor in regulating the central circadian rhythm, including the modulation of our sleep/wake cycles. Sunlight had also been discovered to have a prominent influence on our skin’s circadian rhythm. Overexposure or …

Editorial: Targeting Human Inflammatory Skin Diseases With Natural Products: Exploring Potential Mechanisms and Regulatory Pathways Open

Bey Hing Goh, Andrei Mocan, Jianbo Xiao, Siau Hui Mah, Wei Hsum Yap · 2021

EDITORIAL article Front. Pharmacol., 15 November 2021Sec. Inflammation Pharmacology https://doi.org/10.3389/fphar.2021.791151

Unraveling the Immunopathogenesis and Genetic Variants in Vasculitis Toward Development of Personalized Medicine Open

Bryan Ju Min Yap, Ashley Sean Lai‐Foenander, Bey Hing Goh, Yong Sze Ong, Acharaporn Duangjai , et al. · 2021

Leukocytoclastic vasculitis (LCV) is a systemic autoimmune disease characterized by the inflammation of the vascular endothelium. Cutaneous small vessel vasculitis (CSVV) and anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculi…

Fibroblast-derived matrices-based human skin equivalent as an in vitro psoriatic model for drug testing Open

Wei Hsum Yap, Toh Yang Cheah, Leng Chuan Yong, Shiplu Roy Chowdhury, Min Hwei Ng , et al. · 2021

Fibroblast-derived matrices-based human skin equivalent as an in vitro psoriatic model for drug testing Open

Wei Hsum Yap, Toh Yang Cheah, Leng Chuan Yong, Shiplu Roy Chowdhury, Min Hwei Ng , et al. · 2021

Psoriasis is a chronic skin disease characterized by thickening and disorganization of the skin's protective barrier. Although current models replicate some aspects of the disease, development of therapeutic strategies have been hindered b…

The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent Open

Camille Keisha Mahendra, Loh Teng‐Hern Tan, Cayvern Kishen Mahendra, Hooi‐Leng Ser, Priyia Pusparajah , et al. · 2021

There are many extrinsic factors that can contribute to the premature aging of the skin. In recent years, the demand for natural cosmetic from the general population has noticeable grow. Therefore, this research aimed to investigate the bi…

Natural products in the management of obesity: Fundamental mechanisms and pharmacotherapy Open

Yinghan Chan, Sin Wi Ng, Joycelin Zhu Xin Tan, Gaurav Gupta, Poonam Negi , et al. · 2021

Obesity is an alarming medical condition, whereby, its prevalence has escalated tremendously across the globe. The aetiology of obesity is obscure and multifactorial, which primarily involves complex interactions between genetic background…

Harnessing the Potential of CRISPR/Cas in Atherosclerosis: Disease Modeling and Therapeutic Applications Open

Wei Sheng Siew, Yin-Quan Tang, Chee Kei Kong, Bey Hing Goh, Serena Zacchigna , et al. · 2021

Atherosclerosis represents one of the major causes of death globally. The high mortality rates and limitations of current therapeutic modalities have urged researchers to explore potential alternative therapies. The clustered regularly int…

Exploring the use of virtual laboratory simulations before, during, and post<span>COVID</span>‐19 recovery phase: An Animal Biotechnology case study Open

Wei Hsum Yap, Ming‐Li Teoh, Yin-Quan Tang, Bey Hing Goh · 2021

This study presents an evaluation of integrating virtual laboratory simulations in assessment design of a biotechnology course at Taylor's University in Malaysia before, during and post‐COVID recovery phases. The purpose was to investigate…

Prioritising topics for developing e-learning resources in healthcare curricula: A comparison between students and educators using a modified Delphi survey Open

Hooi Min Lim, Chirk Jenn Ng, Chin Hai Teo, Ping Yein Lee, Puteri Shanaz Jahn Kassim , et al. · 2021

Background Engaging students in the e-learning development process enhances the effective implementation of e-learning, however, students’ priority on the topics for e-learning may differ from that of the educators. This study aims to comp…

Participatory Approach in Reusable Learning Object (RLO) Development Using ASPIRE Framework Open

Nurhanim Hassan, Renukha Sellappans, Phelim Yong Voon Chen, Wei Hsum Yap, Enna Ayub , et al. · 2020

A reusable learning object (RLO) is a type of e-learning resource developed that can be reused again in a variety of different e-learning activities, modules, and courses. Each has its own learning objective, but they can still be combined…

Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review Open

Kang Nien How, Wei Hsum Yap, Calvin Lai Hock Lim, Bey Hing Goh, Zee Wei Lai · 2020

Hyaluronic acid (HA), a major component of extracellular matrix has been widely applied in pharmaceutical and cosmetic industries due to its reported pharmacological properties. Various types of HA drug delivery system including nanopartic…

Angelicin—A Furocoumarin Compound With Vast Biological Potential Open

Camille Keisha Mahendra, Loh Teng‐Hern Tan, Wai-Leng Lee, Wei Hsum Yap, Priyia Pusparajah , et al. · 2020

Angelicin, a member of the furocoumarin group, is related to psoralen which is well known for its effectiveness in phototherapy. The furocoumarins as a group have been studied since the 1950s but only recently has angelicin begun to come i…

Honokiol: A Review of Its Anticancer Potential and Mechanisms Open

Chon Phin Ong, Wai Leong Lee, Yin-Quan Tang, Wei Hsum Yap · 2019

Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is largely caused by a variety of gene mutations. There are continuous efforts being made to develop effective cancer treatments as resistance to current…

A reliable and reproducible assay for determining the effect of natural product on macrophages lipid uptake and cholesterol efflux: A case study of maslinic acid Open

Bee Kee Ooi, Nafees Ahemad, Wei Hsum Yap · 2019

Macrophage foam cell formation represents a key feature that contributes to the development of atherosclerotic lesions. Assessment of cardioprotective natural compounds targeting macrophage foam cell formation processes including lipid upt…

Role Play in Drug Discovery and Development: Biosciences student performance and perspectives when role play experiential learning activities are integrated into learning Open

Wei Hsum Yap · 2019

Objectives: Science education should not be viewed as absolute and unchanging. Instead of teaching a multitude of facts that might change tomorrow, there should be an emphasis on supporting learners to develop adaptability and ability to c…

Model of Experimentation for Photoprotective Properties of Natural Products Against Ultraviolet C (UVC) Damage: A Case Study On Rosmarinic Acid Open

Camille Keisha Mahendra, Loh Teng‐Hern Tan, Wei Hsum Yap, Chim Kei Chan, Prithvy Lingham , et al. · 2019

UVC is one of the three forms of ultraviolet radiation that is produced by the sun and is harmful to those who are exposed to it. On earth, our ozone layer acts as a filter against UVC (solar UVC) from the sun. However, this is not the cas…

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