Explanipedia

Study on harmless degradation of SF6 using water vapor-synergized Fe2O3-filled catalyst Open

Ying Zhang, Ming‐Wei Wang, Zhe Huang, Yalong Li, Zhaodi Yang , et al. · 2025

Sulfur hexafluoride (SF6) gas is widely used in high-voltage gas-insulated equipment due to its excellent electrical insulation and arc-quenching properties. Given that SF6 is a strong greenhouse gas, its degradation treatment represents a…

FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer Open

Xiaoyu Pu, Kexin Chen, Lihua Dong, Junxuan Yi, Ming‐Wei Wang , et al. · 2025

Molecular mechanisms of PI3Kα activation by small-molecule activator 1938 and cancer-specific mutation H1047R Open

Xiao Liu, Qingtong Zhou, Yanyan Chen, Wei Han, Jie Li , et al. · 2025

Divergent activation patterns of BRS3 revealed by two Chinese herb-derived agonists Open

Jie Li, Changyao Li, Qingtong Zhou, Wei Han, Mingzhu Fang , et al. · 2025

FtsZ as a novel target for antibiotics development: Promises and challenges Open

Ming‐Wei Wang, Kaini Hang, Wei Han, Xin Li, Qingtong Zhou , et al. · 2025

Filamenting temperature-sensitive mutant Z (FtsZ), a protein essential for bacterial cell division, is highly conserved across bacterial species but absent in humans, positioning it as a strategic target for the development of antibiotics.…

Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4 Open

Yan Chen, Qingtong Zhou, Shiyu Yan, J.J. Yan, Dehua Yang , et al. · 2025

GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity Open

Xinfeng Wei, Wei Wei, Hongmei Liu, Junxuan Yi, Ming‐Wei Wang , et al. · 2025

CNN-LSTM-Attention with PSO optimization for temperature and fault prediction in meat grinder motors Open

Yao Zhang, Pengfei Zhang, Wenchao Zhang, Ming‐Wei Wang · 2025

Meat grinders are essential in meat production, and predicting the working parameters of the meat grinder motors can help prevent potential failures by providing timely warnings. In this paper, a deep learning model, CNN-LSTM-AP, is develo…

Phase separation of MRG15 delays cellular senescence Open

Yuwen Li, Xinrong Jin, Chunyu Yu, Min Zuo, Liquan Hong , et al. · 2025

Phase separation, a biophysical process that segregates subcellular environments into condensates, has been recognized for its role in transcriptional regulation. However, the extent of its influence on cellular senescence processes remain…

GATA1-mediated Notch signaling augment antitumor immunity of CD11b+CD27− natural killer cells maturation via BCL9/β-catenin signal Open

Fan Yang, Anqi Li, Yuanyuan Zhu, Yan Zhou, Enming Tian , et al. · 2025

The maturation process of natural killer (NK) cells is integral to their antitumor immune response. Despite the diverse effector properties exhibited during differentiation, targeting the fate of NK cells for immunotherapy remains challeng…

Temporal dynamics and clinical correlates of ischemic J waves in the early phase of acute myocardial infarction Open

Huanhuan Hu, Lu Huang, Dewen Zhu, Ming‐Wei Wang, Deye Yang , et al. · 2025

Ischemic J waves are most detectable within the first hour of chest discomfort in AMI patients and are independently associated with STEMI, bradycardia, hyperglycemia, and specific ECG changes.

Associations of compound hot extremes and heat waves with first-ever stroke morbidity in the context of climate change Open

Chenlu Yang, Ming‐Wei Wang, Zhoupeng Ren, Yike Li, Yonglin Hou , et al. · 2025

Climate change has increased the frequency and intensity of abnormal weather, with current daytime and nighttime temperatures being higher than their historical counterparts. Previous studies have focused on exploring the health hazards of…

Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs Open

Canrong Wu, Yong Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai , et al. · 2025

Design and functional characterization of a tetravalent NK cell-engaging bispecific antibody with enhanced half-life for CD30+ lymphoma Open

Caizhi Zhao, Liping Xie, Ming‐Wei Wang, Youjia Hu · 2025

Dynamic niche technology based hybrid breeding optimization algorithm for multimodal feature selection Open

Ting Cai, Fan Ma, Zhiwei Ye, Zhou Wen, Ming‐Wei Wang , et al. · 2025

Alzheimer’s disease with depression: clinical characteristics and potential mechanisms involving orexin and brain atrophy Open

Jing Li, Tenghong Lian, Jinghui Li, Ning Wei, Peng Guo , et al. · 2025

Construction and application of a large capacity VNAR library from the whitespotted bamboo shark (Chiloscyllium playgiosum) Open

Hao Li, Litong Liu, Xinyi Kang, Chuan-Wei Chen, Mengran Wang , et al. · 2025

Fifty whitespotted bamboo sharks (Chiloscyllium playgiosum) of both sexes were used to establish a large capacity variable domain of the new antigen receptor (VNAR) library with a total capacity of over 10⁹ colony-forming…

Structurally Diverse New Metabolites from Three Hadal Trench-Derived Microorganisms Open

Qingyun Peng, Wenjia Huang, Xiǎo Zhang, Xiaoyan Pang, Yunan Liu , et al. · 2025

Two new tetraene lactone derivatives (1 and 2), two new α-pyrone derivatives (3 and 4), three compounds reported as natural products for the first time [an α-pyrone derivative (5), an indole-diketopiperaz…

Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis Open

Bo Pan, Yiming Pan, Yusong Huang, Yi Meng, Yuwei Hu , et al. · 2025

Association between the triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes mellitus in non-alcoholic fatty liver disease Open

Liya Bian, Ting Tang, Qingwen Yu, Xuhan Tong, Siqi Hu , et al. · 2024

Hybrid rice optimization algorithm inspired grey wolf optimizer for high-dimensional feature selection Open

Zhiwei Ye, Ruoxuan Huang, Wen Zhou, Ming‐Wei Wang, Ting Cai , et al. · 2024

Machine Learning-Based Research on the Adaptability of Adolescents to Online Education Open

Ming‐Wei Wang, Xiayan Shen, Sitong Liu · 2024

With the rapid advancement of internet technology, the adaptability of adolescents to online learning has emerged as a focal point of interest within the educational sphere. However, the academic community's efforts to develop predictive m…

Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters Open

Shen-Ming Huang, Zhizhen Huang, Lei Liu, Meng-Yao Xiong, Chao Zhang , et al. · 2024

Urea's transmembrane transport through urea transporters (UT) is a fundamental physiological behavior for life activities. Here, we present 11 cryo-EM structures of four UT members in resting states, urea transport states, or inactive stat…

Structural insights into human zinc transporter ZnT1 mediated Zn2+ efflux Open

Yonghui Long, Zhini Zhu, Zixuan Zhou, Chuanhui Yang, Yulin Chao , et al. · 2024

Zinc transporter 1 (ZnT1), the principal carrier of cytosolic zinc to the extracellular milieu, is important for cellular zinc homeostasis and resistance to zinc toxicity. Despite recent advancements in the structural characterization of v…

Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology Open

Qingtong Zhou, G. Li, K Hang, Jie Li, Dehua Yang , et al. · 2024

Obesity and type 2 diabetes mellitus (T2DM) impact more than 2.5 billion adults worldwide, necessitating innovative therapeutic approaches. Unimolecular polypharmacology, which involves designing single molecules to target multiple recepto…

Predictive effect of lipopolysaccharide-stimulated inflammatory cytokines on symptoms of generalized anxiety disorder Open

Wenyuan Wang, Na Liu, Xiaoxiao Qi, Bing Han, Jing-Na Sun , et al. · 2024

BACKGROUND Generalized anxiety disorder (GAD) is a relatively common mental disorder. Recently, inflammation, an important factor for the development of depression, has attracted increasing attention. Several studies have shown that inflam…

Dynamic Niches-Based Hybrid Breeding Optimization Algorithm for Solving Multi-Modal Optimization Problem Open

Ting Cai, Ziteng Qiao, Zhiwei Ye, Pan Hu, Ming‐Wei Wang , et al. · 2024

Some problems exist in classical optimization algorithms to solve multi-modal optimization problems and other complex systems. A Dynamic Niches-based Improved Hybrid Breeding Optimization (DNIHBO) algorithm is proposed to address the multi…

Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9–36) in conjunction with LSN3318839 Open

Jie Li, G. Li, Yiting Mai, Xiao Liu, Dehua Yang , et al. · 2024

Single-cell mapping of peripheral blood mononuclear cells reveals key transcriptomic changes favoring coronary artery lesion in IVIG-resistant Kawasaki disease Open

Yuanzheng Zheng, Yan Zhou, Di Zhu, Xing Fu, Cao Xie , et al. · 2024

Machine Learning-Based Research on the Adaptability of Adolescents to Online Education Open

Ming‐Wei Wang, Sitong Liu · 2024

With the rapid advancement of internet technology, the adaptability of adolescents to online learning has emerged as a focal point of interest within the educational sphere. However, the academic community's efforts to develop predictive m…

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