Wei Gu
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View article: An Animal Model of Liuzijue Based on Kinematic Features Exploration: A Pilot Study Conducting in COPD
An Animal Model of Liuzijue Based on Kinematic Features Exploration: A Pilot Study Conducting in COPD Open
Background Liuzijue is an essential nonpharmacological intervention within the comprehensive management strategies for chronic obstructive pulmonary disease (COPD) patients. However, the absence of an animal model for Liuzijue presents met…
View article: Cytokine-driven cellular polarization in preeclampsia revealed through the “Dictionary of immune responses”
Cytokine-driven cellular polarization in preeclampsia revealed through the “Dictionary of immune responses” Open
Background Preeclampsia (PE) is a pregnancy-related hypertensive disorder and a leading cause of maternal and perinatal mortality. Current treatments focus primarily on symptom management, as delivery remains the only definitive cure. This…
View article: Research on the Innovation and Long-term Development of the Practical Teaching System of the Major in Social Sports Instruction and Management Driven by the Engine of the Grand Health Industry
Research on the Innovation and Long-term Development of the Practical Teaching System of the Major in Social Sports Instruction and Management Driven by the Engine of the Grand Health Industry Open
Driven by the dual forces of the "Healthy China 2030" strategy and the vigorous development of the grand health industry, the major in Social Sports Instruction and Management, as the core carrier for cultivating talents in national health…
View article: C-BIOPRED severe asthma clinical phenotypes: link to complement and coagulation pathways and galectin 10
C-BIOPRED severe asthma clinical phenotypes: link to complement and coagulation pathways and galectin 10 Open
Background Severe asthma is a heterogeneous airway inflammatory disease presenting with varying clinicophysiological characteristics and response to treatments. The objectives of the present study were to determine the clinical phenotypes …
View article: Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway
Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway Open
View article: Research on the Ideological and Political Design and Implementation Path of Physical Education Courses in Colleges and Universities under the Background of the Construction of "Four New" Majors
Research on the Ideological and Political Design and Implementation Path of Physical Education Courses in Colleges and Universities under the Background of the Construction of "Four New" Majors Open
This article takes the design and implementation of college physical education courses under the background of the "four new" construction as the perspective, is oriented towards the talent needs of new technologies, new business forms, ne…
View article: The Realistic Dilemma and Implementation Path of Campus Football Development in Minority Areas under the Background of Rural Revitalization Strategy
The Realistic Dilemma and Implementation Path of Campus Football Development in Minority Areas under the Background of Rural Revitalization Strategy Open
On February 25, 2021, the National Poverty Alleviation Commendation Conference solemnly announced to the world that poverty alleviation has achieved comprehensive victory. Rural revitalization strategy is the new era to accelerate rural de…
View article: Study on the Co-Development Path between the Ideological and Political Thinking of Physical Education Curriculum and the Consciousness of the Chinese Nation Community in the Frontier Minority Areas
Study on the Co-Development Path between the Ideological and Political Thinking of Physical Education Curriculum and the Consciousness of the Chinese Nation Community in the Frontier Minority Areas Open
Cast firmly the Chinese nation community consciousness, is to safeguard the fundamental interests of the ethnic groups is the inevitable requirement of realizing the great rejuvenation of the Chinese nation is the inevitable requirement of…
View article: Lower levels of vitamin D are associated with an increase in carotid intima-media thickness in children and adolescents with obesity
Lower levels of vitamin D are associated with an increase in carotid intima-media thickness in children and adolescents with obesity Open
Background: the relationship between vitamin D deficiency and carotid intima-media thickness (CIMT) in children and adolescents with obesity is unknown. The aim of this study was to investigate the correlation between vitamin D levels and …
View article: Effects of laryngeal mask ventilation on postoperative atelectasis in children undergoing day surgery: a randomized controlled trial
Effects of laryngeal mask ventilation on postoperative atelectasis in children undergoing day surgery: a randomized controlled trial Open
Background To compare the effects of laryngeal mask mechanical ventilation and preserved spontaneous breathing on postoperative atelectasis in children undergoing day surgery. Methods Children aged 3–7 who underwent elective day surgery we…
View article: Stachydrine ameliorates hypoxia reoxygenation injury of cardiomyocyte via enhancing SIRT1-Nrf2 pathway
Stachydrine ameliorates hypoxia reoxygenation injury of cardiomyocyte via enhancing SIRT1-Nrf2 pathway Open
View article: #430 DB-1303, a HER2-targeting ADC, for patients with advanced/metastatic endometrial cancer: preliminary clinical results from an ongoing phase 1/2a trial (NCT05150691)
#430 DB-1303, a HER2-targeting ADC, for patients with advanced/metastatic endometrial cancer: preliminary clinical results from an ongoing phase 1/2a trial (NCT05150691) Open
Introduction/Background DB-1303 is an antibody-drug conjugate (ADC) consisting of a humanized anti-HER2 IgG1 monoclonal antibody, covalently linked to a proprietary DNA topoisomerase I inhibitor (P1003) via a maleimide tetrapeptide-based c…
View article: Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury
Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury Open
Background. High morbidity of nonspecific low back pain (NLBP) and large consumption of medical resources caused by it have become a heavy social burden. There are many factors inducing NLBP, among which the damage and atrophy of multifidu…
View article: A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance
A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance Open
As a conceptual model of disease mechanisms, a disease map integrates available knowledge and is applied for data interpretation, predictions and hypothesis generation. It is possible to model disease mechanisms on different levels of gran…
View article: Supplementary Figures (Figure S1 - S7) from SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
Supplementary Figures (Figure S1 - S7) from SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation Open
Figure S1 shows the SIRT5 interaction network and SHMT2 identification. Figure S2 shows that SIRT5 is irreplaceable for cancer cell in response to serine deprivation. Figure S3 shows that SIRT5 desuccinylates SHMT2. Figure S4 shows that SI…
View article: Supplementary Figures S1 to S7 from Peli1 Modulates the Subcellular Localization and Activity of Mdmx
Supplementary Figures S1 to S7 from Peli1 Modulates the Subcellular Localization and Activity of Mdmx Open
These extra data provide additional evidence indicating the crucial role of Peli1 in modulating the activities of Mdmx and p53.
View article: Supplementary Data from Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M–positive Non–Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study
Supplementary Data from Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M–positive Non–Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study Open
Supplementary Figure 2
View article: Figure S3 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
Figure S3 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 Open
The loss of OTUB1 induces ferroptosis in H1299 cells
View article: Figure S8 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
Figure S8 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 Open
SLC7A11 interacts with the standard form of CD44
View article: Supplementary Data from Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M–positive Non–Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study
Supplementary Data from Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M–positive Non–Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study Open
Supplementary Figure 1
View article: Figure S1 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
Figure S1 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 Open
SLC3A2 is present in the SLC7A11 complex
View article: Figure S5 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
Figure S5 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 Open
OTUB1 is overexpressed in human cancers
View article: Supplementary Figures and tables from Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function
Supplementary Figures and tables from Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function Open
Additional data to support the main conclusion. Supplemental Figures 1-7 and tables 1-2.
View article: Data from Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function
Data from Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function Open
p53 is a short-lived protein with low basal levels under normal homeostasis conditions. However, upon DNA damage, levels of p53 dramatically increase for its activation. Although robust stabilization of p53 serves as a “trademark” for DNA …
View article: Data from Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function
Data from Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function Open
p53 is a short-lived protein with low basal levels under normal homeostasis conditions. However, upon DNA damage, levels of p53 dramatically increase for its activation. Although robust stabilization of p53 serves as a “trademark” for DNA …
View article: Figure S1 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
Figure S1 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 Open
SLC3A2 is present in the SLC7A11 complex
View article: Data from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
Data from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 Open
Although cell-cycle arrest, senescence, and apoptosis are established mechanisms of tumor suppression, accumulating evidence reveals that ferroptosis, an iron-dependent, nonapoptotic form of cell death, represents a new regulatory pathway …
View article: Figure S5 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
Figure S5 from The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 Open
OTUB1 is overexpressed in human cancers
View article: Supplementary Data from Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M–positive Non–Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study
Supplementary Data from Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M–positive Non–Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study Open
Supplementary Figure 1
View article: Data from SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
Data from SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation Open
The mitochondrial serine hydroxymethyltransferase SHMT2, which catalyzes the rate-limiting step in serine catabolism, drives cancer cell proliferation, but how this role is regulated is undefined. Here, we report that the sirtuin SIRT5 des…