Gaik W. Tew
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View article: Bronchial gene expression clustering in COPD identifies a subgroup of patients with higher level of bronchial T-cells and accelerated lung function decline
Bronchial gene expression clustering in COPD identifies a subgroup of patients with higher level of bronchial T-cells and accelerated lung function decline Open
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with varying degrees of airway wall thickening, chronic bronchitis, and emphysema. A better understanding of the underlying pathology is needed to improve the personal…
View article: Bioactive lipid lysophosphatidic acid species are associated with disease progression in idiopathic pulmonary fibrosis
Bioactive lipid lysophosphatidic acid species are associated with disease progression in idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality. Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient management. Since the lysophosphatidic acid (LPA) pathway h…
View article: Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response
Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response Open
To the editor, Large variation in response to inhaled corticosteroids (ICS) has been reported in both asthma and chronic obstructive pulmonary disease (COPD), which may partly be explained by genetic factors. The transcriptome of the airwa…
View article: The Microbiome in Bronchial Biopsies from Smokers and Ex-Smokers with Stable COPD - A Metatranscriptomic Approach
The Microbiome in Bronchial Biopsies from Smokers and Ex-Smokers with Stable COPD - A Metatranscriptomic Approach Open
Current knowledge about the respiratory microbiome is mainly based on 16S ribosomal RNA gene sequencing. Newer sequencing approaches, such as metatranscriptomics, offer the technical ability to measure the viable microbiome response to env…
View article: Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways
Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways Open
Funder: Dutch Research Council (NWO)
View article: Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease
Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease Open
Background Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid (LPA) has been implicated in airway inflammation but the significanc…
View article: High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis
High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis Open
Introduction COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in neutrophilic or eosinophilic inflammatory responses. A noninvasive peripheral bio…
View article: Comparison of genome-wide gene expression profiling by RNA Sequencing<i>versus</i>microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
Comparison of genome-wide gene expression profiling by RNA Sequencing<i>versus</i>microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights? Open
More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq resu…
View article: Serum Lysophosphatidic Acid Measurement by Liquid Chromatography–Mass Spectrometry in COPD Patients
Serum Lysophosphatidic Acid Measurement by Liquid Chromatography–Mass Spectrometry in COPD Patients Open
Lysophospholipids are bioactive signaling molecules derived from cell membrane glycerophospholipids or sphingolipids and are highly regulated under normal physiological conditions. Lysophosphatidic acids (LPAs) are a class of lysophospholi…
View article: Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways
Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways Open
Background The recent outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has led to a worldwide pandemic. A subset of COVID-19 patients progresses to severe disea…
View article: Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis
Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis Open
BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5 as a potential biomarker of clinic…
View article: RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD
RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD Open
Background The receptor for advanced glycation end products (RAGE) and Toll‐like receptor 4 (TLR4) is implicated in COPD. Although these receptors share common ligands and signalling pathways, it is not known whether they act in concert to…
View article: microRNA–mRNA regulatory networks underlying chronic mucus hypersecretion in COPD
microRNA–mRNA regulatory networks underlying chronic mucus hypersecretion in COPD Open
Chronic mucus hypersecretion (CMH) is a common feature in chronic obstructive pulmonary disease (COPD) and is associated with worse prognosis and quality of life. This study aimed to identify microRNA (miRNA)–mRNA regulatory networks under…
View article: αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis
αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis Open
αEβ7 integrin expression on human colonic CD4+ T cells was associated with increased production of pro-inflammatory Th1, Th17 and Th17/Th1 cytokines, with reduced expression of regulatory T cell-associated markers. These data suggest colon…