Wei Luo
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View article: Safety and Efficacy of Vadadustat Versus Darbepoetin Alfa for Chronic Kidney Disease–Related Anemia in Patients Receiving Dialysis by Baseline Erythropoiesis‐Stimulating Agent Dose
Safety and Efficacy of Vadadustat Versus Darbepoetin Alfa for Chronic Kidney Disease–Related Anemia in Patients Receiving Dialysis by Baseline Erythropoiesis‐Stimulating Agent Dose Open
Introduction Erythropoiesis‐stimulating agents (ESAs) and iron supplementation are standard treatments for chronic kidney disease (CKD)–related anemia. Targeting higher hemoglobin values in CKD increases cardiovascular risk. Whether the in…
View article: Study on the effectiveness of implementing case-based learning within the CDIO framework in an “evidence-based nursing” curriculum: a longitudinal study
Study on the effectiveness of implementing case-based learning within the CDIO framework in an “evidence-based nursing” curriculum: a longitudinal study Open
Background Evidence-based nursing curriculum is a key course to develop nursing students’ evidence-based practice competencies. How to plan and design an evidence-based nursing curriculum to improve students’ competencies has been an issue…
View article: Late Cretaceous tin mineralization at the Dalong deposit in the Baoshan district (NW Yunnan), SW China: Constraints from cassiterite U-Pb geochronology and trace element geochemistry
Late Cretaceous tin mineralization at the Dalong deposit in the Baoshan district (NW Yunnan), SW China: Constraints from cassiterite U-Pb geochronology and trace element geochemistry Open
View article: ATP13A2 restrains macrophage NLRP3 activation to repress neurodegeneration via modulating mitochondrial homeostasis 9349
ATP13A2 restrains macrophage NLRP3 activation to repress neurodegeneration via modulating mitochondrial homeostasis 9349 Open
Description Neuro-immune crosstalk has become increasingly recognized in Parkinson’s disease (PD). ATP13A2, a key genetic factor associated with PD, is well-known for its critical neuroprotective role. However, it remains unclear whether m…
View article: Opportunities and challenges in the application of spatiotemporal transcriptomics in plant research
Opportunities and challenges in the application of spatiotemporal transcriptomics in plant research Open
Spatiotemporal heterogeneity is recognized as a key driver of functional diversity in tissues. Spatial transcriptomics, which integrates high-throughput transcriptomics with high-resolution tissue imaging, enables the precise mapping of ge…
View article: <scp><i>RRP12</i></scp> Variants Are Associated With Autosomal Recessive Brain Calcifications
<span><i>RRP12</i></span> Variants Are Associated With Autosomal Recessive Brain Calcifications Open
Background Primary brain calcifications are observed in several inherited diseases due to different pathogenic mechanisms, including the disruption of the neurovascular unit, mitochondrial dysfunction, and impaired nucleic acid metabolism.…
View article: Enhancer-mediated NR2F2 recruitment activates BGN to promote tumor growth and shape tumor microenvironment in papillary thyroid cancer
Enhancer-mediated NR2F2 recruitment activates BGN to promote tumor growth and shape tumor microenvironment in papillary thyroid cancer Open
Background: Biglycan (BGN), a component of the extracellular matrix, has been closely associated with tumor progression. This study aimed to investigate the endocrine and paracrine roles of BGN in papillary thyroid carcinoma (PTC) t…
View article: An injectable hyaluronic acid–silanol hydrogel containing arginine and puerarin for immune modulation and enhanced diabetic wound healing
An injectable hyaluronic acid–silanol hydrogel containing arginine and puerarin for immune modulation and enhanced diabetic wound healing Open
View article: Integrated Transcriptomic and Proteomic Analyses Revealed the Mechanism of the Osmotic Stress Response in Lacticaseibacillus rhamnosus ATCC 53103
Integrated Transcriptomic and Proteomic Analyses Revealed the Mechanism of the Osmotic Stress Response in Lacticaseibacillus rhamnosus ATCC 53103 Open
Lacticaseibacillus rhamnosus (Lbs. rhamnosus) is renowned for its tolerance to gastric acid and adaptability to bile and alkaline conditions, and is crucial for intestinal health and immune regulation. In this study, integrated transcripto…
View article: Familial adult myoclonus epilepsy: A comprehensive diagnostic strategy for clinical practice
Familial adult myoclonus epilepsy: A comprehensive diagnostic strategy for clinical practice Open
Familial adult myoclonus epilepsy (FAME) is a genetic neurological disorder characterized by cortical myoclonus and epileptic seizures with clinical features that overlap with other movement disorders and epileptic syndromes, particularly …
View article: Cardiomyocyte-derived exosomes: linking heart failure to tumour progression
Cardiomyocyte-derived exosomes: linking heart failure to tumour progression Open
Background It has been shown that heart failure (HF) promotes tumour growth circulating factors. Exosomes, extracellular vesicles (30–150 nm) with lipid bilayer membranes, mediate intercellular communication. We hypothesize that exosomes f…
View article: AlphaFold3-guided single-amino acid substitution creates a dual-functional selection marker for herbicide resistance and genetic tagging in the cruciferous plant pathogen Colletotrichum higginsianum
AlphaFold3-guided single-amino acid substitution creates a dual-functional selection marker for herbicide resistance and genetic tagging in the cruciferous plant pathogen Colletotrichum higginsianum Open
View article: Integrative Multi-Omics Analysis Reveals Key Metabolic Regulators and Prognostic Biomarkers in Pediatric and Adult Thyroid Cancer
Integrative Multi-Omics Analysis Reveals Key Metabolic Regulators and Prognostic Biomarkers in Pediatric and Adult Thyroid Cancer Open
Thyroid cancer, including papillary thyroid carcinoma (PTC) and anaplastic thyroid carcinoma (ATC), exhibits distinct molecular characteristics in adult and pediatric populations. Understanding these differences is vital for identifying th…
View article: Teaching NeuroImage: X-Linked Adrenoleukodystrophy With Rare Temporal Pole Involvement
Teaching NeuroImage: X-Linked Adrenoleukodystrophy With Rare Temporal Pole Involvement Open
View article: Evaluating dental health in patients with different severity of Parkinson’s disease: a cross-sectional study
Evaluating dental health in patients with different severity of Parkinson’s disease: a cross-sectional study Open
Not applicable.
View article: Global burden of diabetes mellitus 1990–2021: epidemiological trends, geospatial disparities, and risk factor dynamics
Global burden of diabetes mellitus 1990–2021: epidemiological trends, geospatial disparities, and risk factor dynamics Open
Diabetes mellitus(DM) remains a significant global health challenge, characterized by high incidence and Disability-adjusted life years (DALYs) rates. A comprehensive understanding of the disease burden of DM is crucial for developing effe…
View article: Contrast-Enhanced Ultrasound of Metastatic Clear Cell Sarcoma of the Liver: A Case Report and Review of the Literature
Contrast-Enhanced Ultrasound of Metastatic Clear Cell Sarcoma of the Liver: A Case Report and Review of the Literature Open
Introduction: Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor derived from neural crest cells, and it exhibits a high tendency for recurrence and metastasis. Distant metastasis significantly affects the prognosis. The incide…
View article: Identification of stemness subtypes and prognostic modeling in thyroid cancer: the critical role of DPYSL3 in tumor progression and immune microenvironment
Identification of stemness subtypes and prognostic modeling in thyroid cancer: the critical role of DPYSL3 in tumor progression and immune microenvironment Open
View article: AD-GCN: A novel graph convolutional network integrating multi-omics data for enhanced Alzheimer’s disease diagnosis
AD-GCN: A novel graph convolutional network integrating multi-omics data for enhanced Alzheimer’s disease diagnosis Open
Alzheimer’s disease (AD) etiology is complex, influenced by demographic risk factors such as age, sex, and educational level, alongside multi-omics factors derived from genomics, transcriptomics, and epigenomics. Advancements in multi-omic…
View article: A Multi-winding Grading Reactor for Distributed Capacitance Compensation of Urbanized Cables
A Multi-winding Grading Reactor for Distributed Capacitance Compensation of Urbanized Cables Open
With the widespread use of underground cables, a large amount of distributed capacitance is added to the urban power grid circuit, which brings great challenges to the transmission capacity and stability of the system. The mainstream suppr…
View article: A novel c.116 - 117 del variant in Unverricht-Lundborg disease: first ULD report in large Chinese population and review of the pathogenetic variants in CSTB gene
A novel c.116 - 117 del variant in Unverricht-Lundborg disease: first ULD report in large Chinese population and review of the pathogenetic variants in CSTB gene Open
View article: The association between the uric acid-to-high-density lipoprotein cholesterol ratio and osteoarthritis risk in U.S. adults: a cross-sectional study based on NHANES 1999–2016
The association between the uric acid-to-high-density lipoprotein cholesterol ratio and osteoarthritis risk in U.S. adults: a cross-sectional study based on NHANES 1999–2016 Open
View article: Investigation of the Impact of Deep Brain Stimulation of the Subthalamic Nucleus on Parkinson Disease Patients with Genetic Risk Factors/Causes
Investigation of the Impact of Deep Brain Stimulation of the Subthalamic Nucleus on Parkinson Disease Patients with Genetic Risk Factors/Causes Open
STN-DBS demonstrated benefits for patients with PD across all genetic backgrounds, but LRRK2 carriers may require increasing stimulation over time, while GBA carriers show reduced motor and quality-of-life improvements.
View article: Novel Phenotypes and Deep Intronic Variant Expand <scp>TH</scp>‐Associated Dopa‐Responsive Dystonia Spectrum
Novel Phenotypes and Deep Intronic Variant Expand <span>TH</span>‐Associated Dopa‐Responsive Dystonia Spectrum Open
Approximately 20% of dopa‐responsive dystonia (DRD) cases remain genetically unresolved. Using whole‐genome sequencing, we identified two TH variants in a young DRD patient, including a novel deep intronic variant. Minigene assays confirme…
View article: The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population
The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population Open
View article: Vascular Access Thrombosis Events in Patients With Dialysis-Dependent CKD Treated With Vadadustat or Darbepoetin Alfa: The INNO2VATE Trial Program
Vascular Access Thrombosis Events in Patients With Dialysis-Dependent CKD Treated With Vadadustat or Darbepoetin Alfa: The INNO2VATE Trial Program Open
View article: Impact of preoperative hyperuricemia on the prognosis of patients with acute type A aortic dissection
Impact of preoperative hyperuricemia on the prognosis of patients with acute type A aortic dissection Open
Preoperative hyperuricemia was an independent risk factor for early mortality in patients with acute type A aortic dissection, but it did not affect the mid-term survival in patients who survived the early postoperative period.
View article: Characterization of avian β-defensin genes in Galliformes reveals widespread evolutionary diversification and distinct evolutionary relationships with infection risk
Characterization of avian β-defensin genes in Galliformes reveals widespread evolutionary diversification and distinct evolutionary relationships with infection risk Open
View article: Combination therapy dramatically promotes remyelination
Combination therapy dramatically promotes remyelination Open
Multiple sclerosis (MS) is an immune-mediated disease in the central nervous system that is characterized by demyelination, axonal degeneration, and progressive neurological disability and is so far incurable. Current medications are predo…
View article: Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant
Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant Open
LRRK2 -related Parkinson’s disease ( LRRK2 -PD) is the most frequent form of monogenic PD worldwide, with important therapeutic opportunities, exemplified by the advancement in LRRK2 kinase inhibition studies/trials. However, many LRRK2 va…