Hongwei Ouyang
YOU?
Author Swipe
View article: Dissecting cross‐lineage tumourigenesis under p53 inactivation through single‐cell multi‐omics and spatial transcriptomics
Dissecting cross‐lineage tumourigenesis under p53 inactivation through single‐cell multi‐omics and spatial transcriptomics Open
Background Tumour suppressor genes, exemplified by TP53 (encoding the human p53), function as critical guardians against tumourigenesis. Germline TP53 ‐inactivating mutations underlie Li‐Fraumeni syndrome, a hereditary cancer predispositio…
View article: A Single‐Component Adhesive Sponge Based on Blood‐Triggered and Autopenetrative Adhesion for Robust Vascular Closure
A Single‐Component Adhesive Sponge Based on Blood‐Triggered and Autopenetrative Adhesion for Robust Vascular Closure Open
Achieving strong adhesion under wet and bleeding conditions remains a major challenge for medical adhesives. Existing strategies that utilize polymer chain penetration to overcome this have shown promise but typically rely on complex exter…
View article: Physical and chemical niche of human growth plate for polarized bone development
Physical and chemical niche of human growth plate for polarized bone development Open
Growth plate (GP), a critical cartilaginous structure in amniotes, underpins longitudinal bone growth, yet the intricate mechanisms behind its polarized mineralization during evolution remain unclear. Herein, employing high-resolution anal…
View article: Targeting of hyperlipid-producing senescent synovial fibroblasts to ameliorate cartilage degeneration
Targeting of hyperlipid-producing senescent synovial fibroblasts to ameliorate cartilage degeneration Open
Osteoarthritis (OA) is one of the most common causes of physical disability among older people and its incidence increases with age. Removal of the senescent cells (SNCs) delays OA pathologies, but little is known about the heterogeneity o…
View article: Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy
Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy Open
Osteoarthritis (OA) is one of the most common joint degenerative diseases without effective treatment, whose pathology is related to the local accumulation of senescent cells (SnCs). However, existing SnCs‐scavenging drugs “senolytics” may…
View article: Releasing Forces in Adhesive Capsulitis Are Important Indicators of Shoulder Stiffness and Postoperative Function
Releasing Forces in Adhesive Capsulitis Are Important Indicators of Shoulder Stiffness and Postoperative Function Open
Background Manipulation under anesthesia is a widely used treatment for frozen shoulder, but the factors that influence patient outcomes after manipulation remain unclear. The degree of shoulder stiffness, a critical feature of frozen shou…
View article: Chromatin-site-specific accessibility: A microtopography-regulated door into the stem cell fate
Chromatin-site-specific accessibility: A microtopography-regulated door into the stem cell fate Open
Biomaterials that mimic extracellular matrix topography are crucial in tissue engineering. Previous research indicates that certain biomimetic topography can guide stem cells toward multiple specific lineages. However, the mechanisms by wh…
View article: A deep learning framework for <i>in silico</i> screening of anticancer drugs at the single-cell level
A deep learning framework for <i>in silico</i> screening of anticancer drugs at the single-cell level Open
Tumor heterogeneity plays a pivotal role in tumor progression and resistance to clinical treatment. Single-cell RNA sequencing (scRNA-seq) enables us to explore heterogeneity within a cell population and identify rare cell types, thereby i…
View article: Divide-and-conquer strategy with engineered “ossification center” organoids for rapid bone healing via recruiting developmental cell community
Divide-and-conquer strategy with engineered “ossification center” organoids for rapid bone healing via recruiting developmental cell community Open
Current approaches for bone repair are often focused on local delivery of growth factors that are aimed at coupled angiogenesis and osteogenesis. However, delayed revascularization and regeneration of severe bone defects are still challeng…
View article: Tissue-engineered Bicipital Autologous Tendon Patch Enhances Massive Rotator Cuff Defect Repair in a Rabbit Infraspinatus Tendon Defect Model
Tissue-engineered Bicipital Autologous Tendon Patch Enhances Massive Rotator Cuff Defect Repair in a Rabbit Infraspinatus Tendon Defect Model Open
Background Massive rotator cuff defects represent an important source of shoulder pain and functional debilitation, substantially diminishing patients’ quality of life. The primary treatment of massive rotator cuff defects includes complet…
View article: Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6
Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6 Open
Ferroptosis of chondrocytes is a significant contributor to osteoarthritis (OA), for which there is still a lack of safe and effective therapeutic drugs targeting ferroptosis. Here, we screen for anti-ferroptotic drugs in Food and Drug Adm…
View article: Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells
Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells Open
Adipose-derived mesenchymal stem cells (ADSCs) and bone marrow-derived mesenchymal stem cells (BMSCs) have shown great potential in clinical applications. However, the similarities and differences between these two cell types have not been…
View article: Engineering biomimetic silk fibroin hydrogel scaffolds with “organic-inorganic assembly” strategy for rapid bone regeneration
Engineering biomimetic silk fibroin hydrogel scaffolds with “organic-inorganic assembly” strategy for rapid bone regeneration Open
Although natural polymers have been widely used in constructing bone scaffolds, it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstanding osteogenic proper…
View article: Rapid tissue adhesive coat improves engraftment efficiency of stem cell therapy
Rapid tissue adhesive coat improves engraftment efficiency of stem cell therapy Open
Stem cell therapy holds promise for treating various diseases, but low engraftment efficacy remains a significant hurdle. Most stem cells are unable to rapidly anchor in the pathological microenvironment, and these dissociated cells underg…
View article: Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses
Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses Open
The anterior cruciate ligament (ACL) is anchored to the femur and tibia by a specialized interface tissue called the enthesis, which transfers forces in multiple directions and magnitudes without accruing fatigue damage during loading cycl…
View article: Hyperplastic Human Macromass Cartilage for Joint Regeneration
Hyperplastic Human Macromass Cartilage for Joint Regeneration Open
Cartilage damage affects millions of people worldwide. Tissue engineering strategies hold the promise to provide off‐the‐shelf cartilage analogs for tissue transplantation in cartilage repair. However, current strategies hardly generate su…
View article: Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development
Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development Open
Osteoarthritis (OA) is one of the most common causes of physical disability among older people and its incidence increases with age. Removal of the senescent cells (SNCs) delays OA pathologies, but little is known about the SNCs in OA syno…
View article: Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells
Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells Open
Understanding the foreign-body response (FBR) of biomaterials is a prerequisite for the prediction of its clinical application, and the present assessments mainly rely on in vitro cell culture and in situ histopathology. However, remote or…