Explanipedia

Bundling gold nanorods with RCA-produced DNA tape into an intelligently reconfigurable nanocluster bomb for multimodal precision cancer therapy Open

Qian Gao, Weijun Wang, Shujuan Sun, Ya Yang, Kaili Mao , et al. · 2025

Programmable DNA Dendrimer from a Single Symmetric Y‐Shaped Structural Unit for Targeted Tumor Therapy with One Hundred Inhibition Efficiency Open

Weijun Wang, Yanru Chen, Jingting Wu, Jinrui Lv, Yaxin Chen , et al. · 2025

Due to fascinating properties, such as structural stability, excellent biocompatibility, and desirable drug delivery efficiency, DNA dendrimer nanostructures are attracting growing scientific interest in biomedical diagnosis and therapy. H…

Synthesis of Irregular Cu2o Nanospheres with Remarkable Electrocatalytic Performance for Non-Enzymatic Glucose Detection Open

Zai‐Sheng Wu, Xiangming Xu, Yang Qi · 2024

Preparation of Irregular Cu2o Nanospheres with a Large Electrochemically Active Area for Non-Enzymatic Glucose Sensors Open

Zai‐Sheng Wu, Xiangming Xu, Yang Qi · 2024

Preparation of Irregular Cu2o Nanospheres with a Large Electrochemically Active Area for Non-Enzymatic Glucose Sensors Open

Zai‐Sheng Wu, Xiangming Xu, Yang Qi · 2024

DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules Open

Weijun Wang, Mengling Lin, Wenqing Wang, Zhifa Shen, Zai‐Sheng Wu · 2023

DNA not only plays a vital role in nature as fundamental hereditary material for storing genetic material, but also serves as well-defined functional material, for example, building blocks for the assembly of nanoscale bio-architectures by…

Dynamic DNA nanomachines for amplification imaging of diseased cells based on stimuli-responsive mechanism Open

Jingting Wu, Wenqing Lin, Zai‐Sheng Wu · 2023

As a basic functional unit, living cell with sophisticated structures play an indispensable role in life activities. Since the abnormality of important molecules inside cells is closely related to diseases, the dynamic analysis and spatio-…

Outward Movement of Targeting Ligands from a Built‐In Reserve Pool in Nuclease‐Resistant 3D Hierarchical DNA Nanocluster for in Vivo High‐Precision Cancer Therapy Open

Weijun Wang, Yansha Gao, Yaxin Chen, Wenqing Wang, Qian Li , et al. · 2022

Nanostructures made entirely of DNAs display great potential as chemotherapeutic drug carriers but so far cannot achieve sufficient clinic therapy outcomes due to off‐target toxicity. In this contribution, an aptamer‐embedded hierarchical …

Visually predicting microRNA-regulated tumor metastasis by intracellularly 3D counting of fluorescent spots based on in situ growth of DNA flares Open

Chang Xue, Huimin Niu, Shuyao Hu, Zhe Yang, Lei Wang , et al. · 2022

The experiments in vitro, ex vivo and in vivo demonstrate that GDPH-based 3D fluorescence counts at the single cell level provide a valuable molecular tool for understanding biological function of miRNAs and especially for recognizing aggr…

Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs Open

Chang Xue, Shuyao Hu, Zhihua Gao, Lei Wang, Mengxue Luo , et al. · 2021

FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis Open

Zhifa Shen, Bowen Liu, Biting Wu, Hongyin Zhou, Xiangyun Wang , et al. · 2021

Most hepatocellular carcinoma (HCC)-associated mortalities are related to the metastasis of cancer cells. The localization of mRNAs and their products to cell protrusions has been reported to play a crucial role in the metastasis. Our prev…

Using porphyrins as albumin-binding molecules to enhance antitumor efficacies and reduce systemic toxicities of antimicrobial peptides Open

Meiru Song, Ge Liu, Yichang Liu, Ziwei Cheng, Haili Lin , et al. · 2021

Nucleic Acids Analysis Open

Yongxi Zhao, Xiaolei Zuo, Qian Li, Feng Chen, Yan-Ru Chen , et al. · 2020

IntracellularNonenzymatic In Situ Growth of Three-DimensionalDNA Nanostructures for Imaging SpecificBiomolecules in Living Cells Open

Ran Liu, Songbai Zhang, Tingting Zheng, Yanru Chen, Jingting Wu , et al. · 2020

Real-time in situ monitoring of low-abundance cancer biomarkers (e.g., miRNAs and proteins) in living cells by nonenzymatic assembly entirely from original DNA probes remains unexplored due to an extremely complex intracellular environment…

A Biofunctional Molecular Beacon for Detecting Single Base Mutations in Cancer Cells Open

Haiyan Dong, Ji Ma, Jie Wang, Zai‐Sheng Wu, Patrick J. Sinko , et al. · 2016

The development of a convenient and sensitive biosensing system to detect specific DNA sequences is an important issue in the field of genetic disease therapy. As a classic DNA detection technique, molecular beacon (MB) is often used in th…

Double-stem Hairpin Probe and Ultrasensitive Colorimetric Detection of Cancer-related Nucleic Acids Open

Jianguo Xu, Hongling Li, Zai‐Sheng Wu, Jun Qian, Chang Xue , et al. · 2015

The development of a versatile biosensing platform to screen specific DNA sequences is still an essential issue of molecular biology research and clinic diagnosis of genetic disease. In this work, we for the first time reported a double-st…

A Catalytic DNA Activated by a Specific Strain of Bacterial Pathogen Open

Zhifa Shen, Zai‐Sheng Wu, Dingran Chang, Wenqing Zhang, Kha Tram , et al. · 2015

Pathogenic strains of bacteria are known to cause various infectious diseases and there is a growing demand for molecular probes that can selectively recognize them. Here we report a special DNAzyme (catalytic DNA), RFD‐CD1, that shows exq…

A Catalytic DNA Activated by a Specific Strain of Bacterial Pathogen Open

Zhifa Shen, Zai‐Sheng Wu, Dingran Chang, Wenqing Zhang, Kha Tram , et al. · 2015

Pathogenic strains of bacteria are known to cause various infectious diseases and there is a growing demand for molecular probes that can selectively recognize them. Here we report a special DNAzyme (catalytic DNA), RFD‐CD1, that shows exq…

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