Wei‐Lie Xiao
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Diaryl pyrimidine guanidine suppresses hepatocellular carcinoma cell stemness by targeting β-catenin signaling Open
Background Liver cancer remains a major global health burden, with hepatocellular carcinoma (HCC) accounting for approximately 80% of liver cancer cases. Cancer stem cells (CSCs) play a critical role in HCC initiation, progression, metasta…
Augmentation of PRDX1–DOK3 interaction alleviates rheumatoid arthritis progression by suppressing plasma cell differentiation Open
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and joint damage, accompanied by the accumulation of plasma cells, which contributes to its pathogenesis. Understanding the genetic alterati…
View article: Accurate Structure Prediction of Natural Products with NatGen
Accurate Structure Prediction of Natural Products with NatGen Open
Natural products (NPs), as a vital source of pharmaceutical agents, have contributed to the development of 60% of marketed small-molecule drugs. However, NP-based drug discovery faces a major challenge due to the combinatorial expansion of…
Ainslials A–C: Three Underscribed Sesquiterpenes From <i>Ainsliaea fragrans</i> Open
Two new isodaucene sesquiterpenes ainslials A–B ( 1–2 ), one new caryophyllene sesquiterpene ainslial C ( 3 ), along with four known compounds ( 4–7 ) were isolated from the whole herb of Ainsliaea fragrans . The structures of new compound…
View article: Nudifloids W‐Y, Three New 3,4‐<i>Seco</i>‐Labdane Diterpenoids With Anti‐Inflammatory Activity From <i>Callicarpa nudiflora</i>
Nudifloids W‐Y, Three New 3,4‐<i>Seco</i>‐Labdane Diterpenoids With Anti‐Inflammatory Activity From <i>Callicarpa nudiflora</i> Open
Three new seco ‐labdane diterpenoids, named nudifloids W‐Y (1–3) , along with twelve known diterpenoids ( 4–15 ) and one sesquiterpenoid ( 16 ) were isolated from the stems and leaves of Callicarpa nudiflora . The chemical structures of co…
Terpenes from <i>Platycladus orientalis</i> and the evaluation of their potential anti-inflammatory activity Open
Two undescribed compounds, including one monoterpene (1) and one sesquiterpene (2), together with eleven known compounds were isolated from Platycladus orientalis. The structures of the isolated compounds were determined by comprehensive s…
Kumujan B suppresses TNF-α-induced inflammatory response and alleviates experimental colitis in mice Open
Graphical Abstract
View article: Two New Eudesmane‐Type Sesquiterpene from <i>Clonostachys</i> sp. Y6‐1and Their Cytotoxic Activity
Two New Eudesmane‐Type Sesquiterpene from <i>Clonostachys</i> sp. Y6‐1and Their Cytotoxic Activity Open
Two undescribed eudesmane‐type sesquiterpenoids together with four known compounds were isolated from Clonostachys sp. Y6‐1 associated. Their chemical structures were unambiguously determined by NMR, mass spectrometry, and 13 C‐NMR calcula…
Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system? Open
Bioactive natural products (BNPs) are the marrow of medicinal plants, which are the secondary metabolites of organisms and have been the most famous drug discovery database. Bioactive natural products are famous for their enormous number a…
View article: CCDC 2203805: Experimental Crystal Structure Determination
CCDC 2203805: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2203807: Experimental Crystal Structure Determination
CCDC 2203807: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2242213: Experimental Crystal Structure Determination
CCDC 2242213: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis
Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis Open
Alkyl salicylaldehyde derivatives are polyketide natural products, which are widely distributed in fungi and exhibit great structural diversity. Their biosynthetic mechanisms have recently been intensively studied; however, how the polyket…
A new acid isolated from V. negundo L. inhibits NLRP3 inflammasome activation and protects against inflammatory diseases Open
The NLRP3 inflammasome plays a critical role in the innate immune response, and its excessive activation will cause pyroptotic cell death and be associated with the onset of inflammatory diseases. However, NLRP3 inflammasome targeting ther…
CCDC 2213759: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2222027: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2213760: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux Open
Introduction: Atherosclerosis is the main cause of many cardiovascular diseases and contributes to morbidity and mortality worldwide. The formation of macrophage-derived foam cells plays a critical role in the early stage of atherosclerosi…
View article: Callintegers A and B, Unusual Tricyclo[4.4.0.0<sup>9,10</sup>]tetradecane Clerodane Diterpenoids from <i>Callicarpa integerrima</i> with Inhibitory Effects on NLRP3 Inflammasome Activation
Callintegers A and B, Unusual Tricyclo[4.4.0.0<sup>9,10</sup>]tetradecane Clerodane Diterpenoids from <i>Callicarpa integerrima</i> with Inhibitory Effects on NLRP3 Inflammasome Activation Open
Callintegers A (1) and B (2), unprecedented clerodane norditerpenoids based on a novel carbon skeleton, were isolated from Callicarpa integerrima. Compounds 1 and 2 possess a novel 6/6/6-fused tricyclic ring system. Their structures and ab…