Weian Zhang
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View article: Construction of NIR-II polymeric photosensitizers and their biomedical applications
Construction of NIR-II polymeric photosensitizers and their biomedical applications Open
View article: “Dual lock-and-key” triggered and endoplasmic reticulum targeting nanophotosensitizers for activatable Type-I photodynamic and photothermal therapies
“Dual lock-and-key” triggered and endoplasmic reticulum targeting nanophotosensitizers for activatable Type-I photodynamic and photothermal therapies Open
A “dual lock-and-key” nanophotosensitizer with ER-targeting capability was constructed for bioimaging-guided phototherapies, which can be activated only by weak acidity and GSH overexpression, leading to tumor specificity and biosafety.
View article: Photodynamic-therapy and chemotherapy of TPBC-PEG nanoplatform encapsulated triptolide synergistically inhibit primary osteosarcoma growth and pulmonary metastasis by activating HIPPO signaling
Photodynamic-therapy and chemotherapy of TPBC-PEG nanoplatform encapsulated triptolide synergistically inhibit primary osteosarcoma growth and pulmonary metastasis by activating HIPPO signaling Open
Osteosarcoma is the most common bone malignancy in children and adolescents with a less than 30% overall survival rate for those with metastatic disease, particularly pulmonary metastases. Drug resistance hinders the effectiveness of curre…
View article: Deep near infrared light-excited stable synergistic photodynamic and photothermal therapies based on P-IR890 nano-photosensitizer constructed via a non-cyanine dye
Deep near infrared light-excited stable synergistic photodynamic and photothermal therapies based on P-IR890 nano-photosensitizer constructed via a non-cyanine dye Open
View article: Advancements of Porphyrin‐Derived Nanomaterials for Antibacterial Photodynamic Therapy and Biofilm Eradication
Advancements of Porphyrin‐Derived Nanomaterials for Antibacterial Photodynamic Therapy and Biofilm Eradication Open
The threat posed by antibiotic‐resistant bacteria and the challenge of biofilm formation has highlighted the inadequacies of conventional antibacterial therapies, leading to increased interest in antibacterial photodynamic therapy (aPDT) i…
View article: Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice
Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice Open
Background Elderly patients suffering from osteoporotic fractures are more susceptible to delayed union or nonunion, and their bodies then are in a state of low-grade chronic inflammation with decreased antioxidant capacity. Tanshinone IIA…
View article: Nanozyme-catalyzed oxygen self-supplying mitochondria-targeting nanoplatform for precise photodynamic therapy
Nanozyme-catalyzed oxygen self-supplying mitochondria-targeting nanoplatform for precise photodynamic therapy Open
Local hypoxia in tumors poses significant challenges to the effectiveness of oxygen-dependent photodynamic therapy (PDT). Herein, a versatile mitochondrial targeting and pH-responsive nanozyme platform (noted as Mito CPs-p) is developed fo…
View article: A TME-enlightened protein-binding photodynamic nanoinhibitor for highly effective oncology treatment
A TME-enlightened protein-binding photodynamic nanoinhibitor for highly effective oncology treatment Open
The efficiency of photodynamic therapy (PDT) is greatly dependent on intrinsic features of photosensitizers (PSs), but most PSs suffer from narrow diffusion distances and short life span of singlet oxygen ( 1 O 2 ). Here, to conquer this i…
View article: A H<sub>2</sub>S‐Generated Supramolecular Photosensitizer for Enhanced Photodynamic Antibacterial Infection and Relieving Inflammation
A H<sub>2</sub>S‐Generated Supramolecular Photosensitizer for Enhanced Photodynamic Antibacterial Infection and Relieving Inflammation Open
Photodynamic therapy (PDT) is a promising treatment against bacteria‐caused infections. By producing large amounts of reactive oxygen species (ROS), PDT can effectively eliminate pathogenic bacteria, without causing drug resistance. Howeve…
View article: Reactive oxygen species (ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession
Reactive oxygen species (ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession Open
View article: Intratibial osteosarcoma growth and pulmonary metastasis inhibition by HIPPO signaling pathway-induced photodynamic therapy
Intratibial osteosarcoma growth and pulmonary metastasis inhibition by HIPPO signaling pathway-induced photodynamic therapy Open
Cancer is a global leading cause of death, with nearly 10 million people dying from cancer in 2020. Photodynamic therapy (PDT) has emerged as a promising cancer treatment modality; however, the potential molecular mechanisms remain obscure…
View article: A supramolecular nanoplatform for imaging-guided phototherapies <i>via</i> hypoxia tumour microenvironment remodeling
A supramolecular nanoplatform for imaging-guided phototherapies <i>via</i> hypoxia tumour microenvironment remodeling Open
A supramolecular platform was constructed for imaging-guided photodynamic and photothermal therapies by hypoxia tumour microenvironment remodeling via the inhibition of mitochondria-associated oxidative phosphorylation and combined therape…
View article: A multifunctional platform with metallacycle-based star polymers and gold nanorods for combinational photochemotherapy
A multifunctional platform with metallacycle-based star polymers and gold nanorods for combinational photochemotherapy Open
Although platinum-based anticancer drugs have prevailed in traditional chemotherapy, the severe side effects and drug resistance hampered their clinical applications. Combinational therapies have exhibited promises in antitumor treatments.…
View article: A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging
A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging Open
View article: A Near-Infrared Organoplatinum(II) Metallacycle Conjugated with Heptamethine Cyanine for Trimodal Cancer Therapy
A Near-Infrared Organoplatinum(II) Metallacycle Conjugated with Heptamethine Cyanine for Trimodal Cancer Therapy Open
Open AccessCCS ChemistryRESEARCH ARTICLE6 Jun 2022A Near-Infrared Organoplatinum(II) Metallacycle Conjugated with Heptamethine Cyanine for Trimodal Cancer Therapy Baoxuan Huang†, Xi Liu†, Guoliang Yang†, Jia Tian, Zhiyong Liu, Yucheng Zhu,…
View article: Boosting cancer therapy efficiency <i>via</i> photoinduced radical production
Boosting cancer therapy efficiency <i>via</i> photoinduced radical production Open
An iodized polymer-based radical nanogenerator, PI/FBC, with strong NIR emission was prepared for NIR-mediated hypoxia-irrelevant tumor therapy.
View article: Regulating the Bacterial Oxygen-Microenvironment via a Perfluorocarbon-Conjugated Bacteriochlorin for Enhanced Photodynamic Antibacterial Efficacy
Regulating the Bacterial Oxygen-Microenvironment via a Perfluorocarbon-Conjugated Bacteriochlorin for Enhanced Photodynamic Antibacterial Efficacy Open
View article: A Hierarchical Supramolecular Nanozyme Platform for Programming Tumor-Specific PDT and Catalytic Therapy
A Hierarchical Supramolecular Nanozyme Platform for Programming Tumor-Specific PDT and Catalytic Therapy Open
View article: An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy
An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy Open
A hypoxia-tolerant photosensitizer FBC-based nanoplatform with strong NIR absorbance and ultra-high stability was facilely prepared for PDT of deep tumors.
View article: Modulation of the lifespan of <i>C. elegans</i> by the controlled release of nitric oxide
Modulation of the lifespan of <i>C. elegans</i> by the controlled release of nitric oxide Open
Schematic illustration of modulating the longevity of the C. elegans by PEG-NORM nanoparticles.
View article: Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy
Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy Open
An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated to avoid residual nanoparticles, thus realizing reliable and effective photodynamic therapy.
View article: Correction: An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors
Correction: An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors Open
Correction for ‘An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors’ by Guoliang Yang et al., Chem. Sci., 2019, 10, 5766–5772, DOI: 10.1039/C9SC00985J.
View article: Self‐Amplified Photodynamic Therapy through the <sup>1</sup>O<sub>2</sub>‐Mediated Internalization of Photosensitizers from a Ppa‐Bearing Block Copolymer
Self‐Amplified Photodynamic Therapy through the <sup>1</sup>O<sub>2</sub>‐Mediated Internalization of Photosensitizers from a Ppa‐Bearing Block Copolymer Open
Nanocarriers are employed to deliver photosensitizers for photodynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages including the premature leakage and non‐selective release of photosensitizers sti…
View article: An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors
An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors Open
An oxygen self-sufficient NIR-responsive nanoplatform enhances the efficiency of synergistic treatments between PDT and chemotherapy in hypoxic tumors.
View article: Adaptive Materials: Light‐Driven Reversible Transformation between Self‐Organized Simple Cubic Lattice and Helical Superstructure Enabled by a Molecular Switch Functionalized Nanocage (Adv. Mater. 26/2018)
Adaptive Materials: Light‐Driven Reversible Transformation between Self‐Organized Simple Cubic Lattice and Helical Superstructure Enabled by a Molecular Switch Functionalized Nanocage (Adv. Mater. 26/2018) Open
Self-organized stimuli-responsive smart materials with adjustable attributes are highly desirable for a plethora of device applications. In article number 1800237, Zhi-Gang Zheng, Weian Zhang, Quan Li, and co-workers demonstrate a light-dr…
View article: Synthesis of functionalized 4H-Chromenes catalyzed by lipase immobilized on magnetic nanoparticles
Synthesis of functionalized 4H-Chromenes catalyzed by lipase immobilized on magnetic nanoparticles Open
In the work, mucor miehei lipase (MML) was covalently immobilized on the 2,4,6-trichloro-1,3,5-triazine (TCT)-modified magnetite nanoparticles. Then, the immobilized MML was utilized in the synthesis of functionalized 4H-Chromenes via a mu…
View article: Integrative Analysis of Transcriptomic and Methylomic Data in Photoperiod-dependent Regulation of Cucumber Sex Expression
Integrative Analysis of Transcriptomic and Methylomic Data in Photoperiod-dependent Regulation of Cucumber Sex Expression Open
This dataset provides information about whole genome bisulphite sequencing (WGBS) and RNA-seq. The plant material is cucumber shoot species that were subjected to photoperiod treatment.
View article: POSS-enhanced thermosensitive hybrid hydrogels for cell adhesion and detachment
POSS-enhanced thermosensitive hybrid hydrogels for cell adhesion and detachment Open
Thermosensitive poly(N-isopropylacrylamide) (PNIPAM)-based substrates have presented great promise in cell sheet engineering.
View article: Sustained release of stem cell factor in a double network hydrogel for ex vivo culture of cord blood‐derived <scp>CD</scp>34<sup>+</sup> cells
Sustained release of stem cell factor in a double network hydrogel for ex vivo culture of cord blood‐derived <span>CD</span>34<sup>+</sup> cells Open
Objectives Stem cell factor ( SCF ) is considered as a commonly indispensable cytokine for proliferation of haematopoietic stem cells ( HSC s), which is used in large dosages during ex vivo culture. The work presented here aimed to reduce …
View article: A mild and efficient Dakin reaction mediated by lipase
A mild and efficient Dakin reaction mediated by lipase Open
We have developed a novel lipase-mediated method to realize the Dakin reaction. A wide range of hydroxylated benzaldehydes could be oxidized with high yields (from 90% to 97%) under mild reaction conditions. Moreover, this lipase-mediated …