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View article: The correlation between anti-phospholipase A2 receptor antibodies and hypercoagulability in patients with idiopathic membranous nephropathy
The correlation between anti-phospholipase A2 receptor antibodies and hypercoagulability in patients with idiopathic membranous nephropathy Open
Our study provides a new perspective on the underlying mechanisms of hypercoagulability in patients with IMN. Anti-PLA2R antibodies are associated with hypercoagulability in patients with IMN and may affect coagulation in patients with IMN…
View article: Clinical features of anemia in membranous nephropathy patients: a Chinese cohort study
Clinical features of anemia in membranous nephropathy patients: a Chinese cohort study Open
The anemia experienced by MN patients is mainly mild and moderate, normocytic anemia. The pathological features of acute renal tubular injury and clinical nutritional status are independent risk factors for anemia. There were differences i…
View article: Non-diabetic urine glucose in idiopathic membranous nephropathy
Non-diabetic urine glucose in idiopathic membranous nephropathy Open
This study aims to analyze the characteristics of idiopathic membranous nephropathy (iMN) with nondiabetic urine glucose during the follow-up. We retrospectively analyzed the data of 1313 patients who were diagnosed iMN. The prevalence of …
View article: Relationship Between Serum Complement C3 Levels and Outcomes Among Patients With Anti-GBM Disease
Relationship Between Serum Complement C3 Levels and Outcomes Among Patients With Anti-GBM Disease Open
Background IgG and complement 3 (C3) are generally found to be deposited along the glomerular basement membrane (GBM) in human anti-GBM disease. The pathogenic role of complement activation in kidney damage of anti-GBM disease has been exp…
View article: Effectiveness and safety of KunXian capsule for the treatment of IgA nephropathy
Effectiveness and safety of KunXian capsule for the treatment of IgA nephropathy Open
Background Tripterygium Wilfordii Hook F (TwHF) preparation has been widely used in the treatments of IgA nephropathy (IgAN) in China. However, the effectiveness and safety of the new generation of TwHF preparation, KuxXian capsule, on the…
View article: POS-662 Inflammation may cause anemia difficult to improve in maintenance hemodialysis patients
POS-662 Inflammation may cause anemia difficult to improve in maintenance hemodialysis patients Open
Renal anemia is caused by reduced erythropoietin (EPO) due to impairment of renal function and structure. Other causes include iron deficiency, inflammation, secondary hyperparathyroidism, and serum toxins that reduce RBC lifespan. After t…
View article: An equation to estimate 24-hour total urine protein excretion rate in patients who underwent urine protein testing
An equation to estimate 24-hour total urine protein excretion rate in patients who underwent urine protein testing Open
Background The urine protein-creatinine ratio (UPCR) in a spot first-morning urine sample is used to estimate 24-h urine proteinuria (24hUP) in patients who underwent urine protein testing. UPCR cannot be directly compared with 24-h protei…
View article: Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury
Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury Open
Objective: Activation of β-catenin causes podocyte injury and proteinuria, but how β-catenin signalling is regulated during podocyte injury remains elusive. Nuclear receptor interacting protein 2 (NRIP2) modulates the Wnt pathway in colore…
View article: HLA Alleles and Prognosis of PLA2R-Related Membranous Nephropathy
HLA Alleles and Prognosis of PLA2R-Related Membranous Nephropathy Open
Background and objectives Associations between HLA alleles and susceptibility to M-type phospholipase A2 receptor (PLA2R)–related membranous nephropathy have been well defined previously in Chinese patients. However, the relationships betw…
View article: P0083HLA-DRB1*1301-DQB*0603-DRB3*0202 HAPLOTYPE IS INDEPENDENTLY ASSOCIATES WIHT POOR PROGNOSIS IN PLA2R-RELATED MEMBRANOUS NEPHROPAHTY
P0083HLA-DRB1*1301-DQB*0603-DRB3*0202 HAPLOTYPE IS INDEPENDENTLY ASSOCIATES WIHT POOR PROGNOSIS IN PLA2R-RELATED MEMBRANOUS NEPHROPAHTY Open
Background and Aims The susceptibility of Idiopathic membranous nephropathy (MN) is associated with HLA alleles. We previously found almost all (98.7%) patients with PLA2R-related MN carry either or both of the HLA-DRB1*1501 and DRB3*0202 …
View article: Characterization of thromboelastography of patients with different pathological types of nephrotic syndrome
Characterization of thromboelastography of patients with different pathological types of nephrotic syndrome Open
To investigate the changes in blood coagulability as measured by thromboelastography (TEG) in patients with nephrotic syndrome of different etiologies as well as in patients with venous thromboembolic events (VTE). From January 2013 to Oct…
View article: Changes in the Spectrum of Kidney Diseases: An Analysis of 40,759 Biopsy-Proven Cases from 2003 to 2014 in China
Changes in the Spectrum of Kidney Diseases: An Analysis of 40,759 Biopsy-Proven Cases from 2003 to 2014 in China Open
Objectives: To evaluate the changing spectrum of kidney diseases over time in China using renal biopsy-proven cases. Methods: All patients over the age of 14 years who were diagnosed with a kidney disease by renal biopsy in the Renal Biops…
View article: HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy
HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy Open
Idiopathic membranous nephropathy (MN) is associated with HLA; however, the HLA allele involved remains unknown. To identify the HLA risk alleles associated with phospholipase A2 receptor (PLA2R)-related MN in the Chinese population, we se…
View article: PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy
PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy Open
The prevalence of serum anti-PLA2R antibody and glomerular expression of PLA2R was significantly lower in patients with psoriasis and MN than in those with idiopathic MN, and THSD7A staining was negative, suggesting that MN is associated w…
View article: Combined Assessment of Phospholipase A2 Receptor Autoantibodies and Glomerular Deposits in Membranous Nephropathy
Combined Assessment of Phospholipase A2 Receptor Autoantibodies and Glomerular Deposits in Membranous Nephropathy Open
Serum phospholipase A2 receptor antibodies (SAbs) and glomerular phospholipase A2 receptor antigen (GAg) deposits have been observed in idiopathic membranous nephropathy (IMN). However, the clinical application of these two biomarkers, par…
View article: Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli
Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli Open
Objective . To investigate potential drugs for diabetic nephropathy (DN) using whole-genome expression profiles and the Connectivity Map (CMAP). Methodology . Eighteen Chinese Han DN patients and six normal controls were included in this s…