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View article: Surgical Treatment for Osteomalacia Induced by Causative Tumor in the Knee Joint Region: A Single‐Center Retrospective Clinical Study Over 10 Years
Surgical Treatment for Osteomalacia Induced by Causative Tumor in the Knee Joint Region: A Single‐Center Retrospective Clinical Study Over 10 Years Open
Objective Tumor‐induced osteomalacia with the culprit tumor located in the knee joint is rare in clinical practice, and previous literature has only been seen in case reports, which pose great challenges to the clinical diagnosis and treat…
View article: Proteomic profiling of bone tissue reveals distinct pathways in men and women with osteoporosis
Proteomic profiling of bone tissue reveals distinct pathways in men and women with osteoporosis Open
Background Osteoporosis is characterised by an imbalance in bone remodelling, yet the detailed molecular mechanisms underlying its pathogenesis remain unclear. This study aimed to identify key proteins and regulatory pathways associated wi…
View article: Editorial: Molecular mechanisms and treatment of monogenic skeletal disorders
Editorial: Molecular mechanisms and treatment of monogenic skeletal disorders Open
View article: Burosumab in Chinese adults with X-linked hypophosphatemia: a phase 4 study
Burosumab in Chinese adults with X-linked hypophosphatemia: a phase 4 study Open
X-linked hypophosphatemia (XLH) is a rare genetic disorder, for which burosumab treatment may be beneficial. This study evaluated the efficacy, pharmacokinetics, and safety of burosumab in Chinese adults with XLH. In this open-label, multi…
View article: <i>Lactobacillus rhamnosus</i> LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes
<i>Lactobacillus rhamnosus</i> LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes Open
BACKGROUND Type 2 diabetes mellitus (T2DM) is a metabolic disorder linked to high blood glucose and gut dysbiosis. Probiotics like Lactobacillus rhamnosus LRa05 may improve glycemic control and gut microbiota. AIM To explore the impact of …
View article: Biomimetic Selenium‐Nanocomposites Alleviate MASH by Modulating Lipid and Iron Homeostasis (Adv. Healthcare Mater. 19/2025)
Biomimetic Selenium‐Nanocomposites Alleviate MASH by Modulating Lipid and Iron Homeostasis (Adv. Healthcare Mater. 19/2025) Open
View article: Effects of asfotase alfa on fracture healing of adult patient with hypophosphatasia and literature review
Effects of asfotase alfa on fracture healing of adult patient with hypophosphatasia and literature review Open
View article: Dynamic changes of bone microarchitecture and volumetric mineral density assessed by HR-pQCT in patients with cervical cancer after concurrent chemoradiotherapy: a prospective study
Dynamic changes of bone microarchitecture and volumetric mineral density assessed by HR-pQCT in patients with cervical cancer after concurrent chemoradiotherapy: a prospective study Open
Bone changes in patients undergoing pelvic radiotherapy remain unclear. This study initially utilized high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess the dynamic changes in bone microarchitecture and volumet…
View article: Analysis of the current status and characteristics of osteoporosis in adult hemophilia patients based on high-resolution peripheral quantitative computed tomography: a case control study
Analysis of the current status and characteristics of osteoporosis in adult hemophilia patients based on high-resolution peripheral quantitative computed tomography: a case control study Open
View article: Two novel rare variants in the PTH gene found in patients with hypoparathyroidism
Two novel rare variants in the PTH gene found in patients with hypoparathyroidism Open
In this study, two novel RVs of PTH (Val52Ile and Leu90Phe) were identified that may impair hormone synthesis and secretion. Our study has broadened the mutation spectrum of the PTH and shed light on potential mechanisms unde…
View article: TBS as a complementary tool for assessing vertebral fractures and spinal deformity in children and adolescents with osteogenesis imperfecta
TBS as a complementary tool for assessing vertebral fractures and spinal deformity in children and adolescents with osteogenesis imperfecta Open
View article: Predicting autoimmune thyroiditis in primary Sjogren’s syndrome patients using a random forest classifier: a retrospective study
Predicting autoimmune thyroiditis in primary Sjogren’s syndrome patients using a random forest classifier: a retrospective study Open
View article: Association between sensitivity to thyroid hormones and trabecular bone score in euthyroid individuals: a population-based cross-sectional study
Association between sensitivity to thyroid hormones and trabecular bone score in euthyroid individuals: a population-based cross-sectional study Open
View article: Targeting Metabolomics in Primary Hypertrophic Osteoarthropathy: Uncovering Novel Insights into Disease Pathogenesis
Targeting Metabolomics in Primary Hypertrophic Osteoarthropathy: Uncovering Novel Insights into Disease Pathogenesis Open
Context Primary hypertrophic osteoarthropathy (PHO) is a rare genetic disorder characterized by skeletal and skin abnormalities. Genetic defects in prostaglandin E2 (PGE2) metabolism are known to cause PHO. However, the global impact and c…
View article: Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks
Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks Open
View article: Alteration of Bone Microarchitecture in Hereditary Distal RTA Patients With <i>SLC4A1</i> Gene Mutation: Assessed by HR-pQCT
Alteration of Bone Microarchitecture in Hereditary Distal RTA Patients With <i>SLC4A1</i> Gene Mutation: Assessed by HR-pQCT Open
Context Hereditary distal renal tubular acidosis caused by SLC4A1 gene mutation (SLC4A1-dRTA) is a rare hereditary form of renal tubular acidosis. Rickets or osteomalacia is a common complication of SLC4A1-dRTA and seriously affects patien…
View article: Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature
Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature Open
View article: Goal-directed osteoporosis treatment: ASBMR/BHOF task force position statement 2024
Goal-directed osteoporosis treatment: ASBMR/BHOF task force position statement 2024 Open
The overarching goal of osteoporosis management is to prevent fractures. A goal-directed approach to long-term management of fracture risk helps ensure that the most appropriate initial treatment and treatment sequence is selected for indi…
View article: Building Predictive Understanding of Microbial Ecology by Bridging Microbial Growth Kinetics and Microbial Population Dynamics
Building Predictive Understanding of Microbial Ecology by Bridging Microbial Growth Kinetics and Microbial Population Dynamics Open
Modeling microbial communities can provide predictive insights into microbial ecology, but current modeling approaches suffer from inherent limitations. In this study, a novel modeling approach was proposed to address those limitations bas…
View article: Associations of different dietary patterns, bone mineral density, and fracture risk among elderly women: the China Osteoporosis Prevalence Study
Associations of different dietary patterns, bone mineral density, and fracture risk among elderly women: the China Osteoporosis Prevalence Study Open
Objective Despite the fact that China amounts to one-fifth of the world’s population, has a higher proportion of the elderly, and has a higher prevalence of osteoporosis and fracture, limited studies have investigated the association betwe…
View article: DeepQCT: Predicting fragility fracture from high-resolution peripheral quantitative CT using deep learning
DeepQCT: Predicting fragility fracture from high-resolution peripheral quantitative CT using deep learning Open
Background Osteoporosis is prevalent in elderly women, which causes fragility fracture and hence increased mortality and morbidity. Predicting osteoporotic fracture risk is both clinically-beneficial and cost-effective. However, traditiona…
View article: Preoperative evaluation and orthopedic surgical strategies for tumor-induced osteomalacia
Preoperative evaluation and orthopedic surgical strategies for tumor-induced osteomalacia Open
Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is very rare, with about 1000 reported cases globally. Removing most TIO culprit tumors requires the evaluation and intervention of orthopedic doctors. However, orthop…
View article: Characterization of Novel <i>PHEX</i> Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation
Characterization of Novel <i>PHEX</i> Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation Open
Background X-linked hypophosphatemia (XLHR) is the most common genetic form of hypophosphatemic rickets (HR), which is caused by phosphate regulating endopeptidase homolog X-linked (PHEX) gene mutation. At present, the genotype–phenotype r…
View article: Disruption of FLNB leads to skeletal malformation by interfering with skeletal segmentation through the HOX gene
Disruption of FLNB leads to skeletal malformation by interfering with skeletal segmentation through the HOX gene Open
Filamin B (FLNB) plays an important role in skeletal development. Mutations in FLNB can lead to skeletal malformation such as an abnormal number of ossification centers, indicating that the skeletal segmentation in the embryonic per…
View article: Genetic Analysis, Phenotypic Spectrum and Functional Study of Rare Osteogenesis Imperfecta Caused by <i>CRTAP</i> Variants
Genetic Analysis, Phenotypic Spectrum and Functional Study of Rare Osteogenesis Imperfecta Caused by <i>CRTAP</i> Variants Open
Objective Deficiency of cartilage-associated protein (CRTAP) can cause extremely rare autosomal recessive osteogenesis imperfecta (OI) type VII. We investigated the pathogenic mechanisms of CRTAP variants through functional studies on bone…
View article: Early bone loss in patients with obstructive sleep apnea: a cross-sectional study
Early bone loss in patients with obstructive sleep apnea: a cross-sectional study Open
View article: Safety and Efficacy of Denosumab in Children With Osteogenesis Imperfecta—the First Prospective Comparative Study
Safety and Efficacy of Denosumab in Children With Osteogenesis Imperfecta—the First Prospective Comparative Study Open
Context Denosumab is a potential therapeutic agent for osteogenesis imperfecta (OI), but its efficacy and safety remain unclear in children with OI. Objective We aimed to investigate the effects of denosumab on bone mineral density (BMD), …
View article: Efficacy and Safety of Denosumab vs Zoledronic Acid in OI Adults: A Prospective, Open-Label, Randomized Study
Efficacy and Safety of Denosumab vs Zoledronic Acid in OI Adults: A Prospective, Open-Label, Randomized Study Open
Context The comparative effectiveness of denosumab and zoledronic acid for adult patients with osteogenesis imperfecta (OI) has not been established. Objective To evaluate the efficacy and safety of denosumab and zoledronic acid in adult p…
View article: DeepQCT: Predicting Fragility Fracture from High-Resolution Peripheral Quantitative CT Using Deep Learning
DeepQCT: Predicting Fragility Fracture from High-Resolution Peripheral Quantitative CT Using Deep Learning Open
View article: Association of Carbohydrates, Fats, and Protein Intake with Type 2 Diabetes Mellitus: A Prospective Cohort Study of UK Biobank Participants
Association of Carbohydrates, Fats, and Protein Intake with Type 2 Diabetes Mellitus: A Prospective Cohort Study of UK Biobank Participants Open