Weida Lu
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View article: Pulmonary function impairment and its relationship with target therapy response in patients with pulmonary arterial hypertension
Pulmonary function impairment and its relationship with target therapy response in patients with pulmonary arterial hypertension Open
Introduction Patients with pulmonary arterial hypertension (PAH) exhibit exertional dyspnea and decreased exercise capacity, which are not solely attributable to right heart dysfunction. Numerous studies have aimed to elucidate pulmonary f…
View article: Pterostilbene mitigates experimental pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition
Pterostilbene mitigates experimental pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition Open
Background The natural compound pterostilbene (PTE) has multiple cardiovascular protective effects. However, its effects on pulmonary arterial hypertension (PAH)-associated vascular remodeling remain to be elucidated. This study investigat…
View article: Congenital heart disease: types, pathophysiology, diagnosis, and treatment options
Congenital heart disease: types, pathophysiology, diagnosis, and treatment options Open
Congenital heart disease (CHD) is a structural abnormality of the heart and/or great vessels and patients with CHD are at an increased risks of various morbidities throughout their lives and reduced long‐term survival. Eventually, CHD may …
View article: Optimal combination of right ventricular functional parameters using echocardiography in pulmonary arterial hypertension
Optimal combination of right ventricular functional parameters using echocardiography in pulmonary arterial hypertension Open
Aims Novel echocardiographic parameters of right ventricular (RV) function, including speckle‐tracking‐derived, three‐dimensional, and RV–pulmonary artery coupling parameters, have emerged for the evaluation of pulmonary arterial hypertens…
View article: General anesthesia is an independent predictor for worse maternal outcome in pregnant pulmonary arterial hypertension patients without cardiac shunt but not for those with shunt
General anesthesia is an independent predictor for worse maternal outcome in pregnant pulmonary arterial hypertension patients without cardiac shunt but not for those with shunt Open
Background Although pregnancy imposes extra risk in patients with pulmonary arterial hypertension (PAH), hemodynamic characteristics vary between PAH patients with and without cardiac shunts. However, previous studies did not take hemodyna…
View article: Potential impact of specific therapy on pregnant women with pulmonary arterial hypertension without cardiac shunt: a descriptive study in northern China
Potential impact of specific therapy on pregnant women with pulmonary arterial hypertension without cardiac shunt: a descriptive study in northern China Open
Background Pregnancy in women with pulmonary arterial hypertension (PAH) is a fatal condition, despite the effectiveness of PAH-specific therapies. The coverage status and effect of specific therapies in pregnant patients with PAH without …
View article: Atrial high-rate episodes intensify R2CHA2DS2-VASc score for prognostic stratification in pacemaker patients
Atrial high-rate episodes intensify R2CHA2DS2-VASc score for prognostic stratification in pacemaker patients Open
Patients with device detected atrial high-rate episodes (AHRE) have an increased risk of MACE. The R 2 CHA 2 DS 2 -VASc, CHADS 2 , R 2 CHADS 2 and CHA 2 DS 2 -VASc score have been investigated for predicting major adverse cardiovascular ev…
View article: Laparoscopic Double Hepatic Artery Banding/Ligation for Patients With Hepatic Hereditary Haemorrhagic Telangiectasia (HHHT)
Laparoscopic Double Hepatic Artery Banding/Ligation for Patients With Hepatic Hereditary Haemorrhagic Telangiectasia (HHHT) Open
Laparoscopic surgery for HHHT is technically challenging. Clinical data and follow up information showed that laparoscopic double hepatic artery banding and or ligation was a technically feasible surgical approach for HHHT patients with si…
View article: Selexipag-based triple combination therapy improves prognosis in Chinese pulmonary arterial hypertension patients
Selexipag-based triple combination therapy improves prognosis in Chinese pulmonary arterial hypertension patients Open
Aim Selexipag is an oral selective prostacyclin receptor agonist approved for treatment of patients with pulmonary arterial hypertension (PAH). In the present study, we aim to assess the safety and efficacy of selexipag in triple combinati…
View article: The performance of five models compared with atrial high rate episodes predicts new atrial fibrillation after cardiac implantable electronic devices implantation
The performance of five models compared with atrial high rate episodes predicts new atrial fibrillation after cardiac implantable electronic devices implantation Open
Aims Several predicting models have been evaluated for new‐onset atrial fibrillation (AF) in several clinical conditions, but never in patients with cardiac implantable electronic devices (CIED). We aimed to evaluate the five predicting mo…
View article: HAT<sub>2</sub>CH<sub>2</sub> score performance predicting neurologic events after cardiac implantable electronic device
HAT<sub>2</sub>CH<sub>2</sub> score performance predicting neurologic events after cardiac implantable electronic device Open
Objectives: The HAT2CH2 score has been evaluated for predicting new-onset atrial fibrillation in several clinical conditions, but never for adverse neurologic events. We aimed to evaluate the effectiveness of HAT2CH2 score in predicting ne…
View article: HAT2CH2 Score Predicts Systemic Thromboembolic Events in Elderly After Cardiac Electronic Device Implantation
HAT2CH2 Score Predicts Systemic Thromboembolic Events in Elderly After Cardiac Electronic Device Implantation Open
Background: The HAT 2 CH 2 score has been evaluated for predicting new onset atrial fibrillation, but never for adverse systemic thromboembolic events (STE) in elderly. We aimed to evaluate the HAT 2 CH 2 score and comparing to atrial high…
View article: HAT2 CH2 Score Performance Predicting Neurologic Events After Cardiac Implantable Electronic Device
HAT2 CH2 Score Performance Predicting Neurologic Events After Cardiac Implantable Electronic Device Open
The HAT 2 CH 2 score has been evaluated for predicting new-onset atrial fibrillation in several clinical conditions, but never for adverse neurologic events. We aimed to evaluate the effectiveness of HAT 2 CH 2 score in predicting neurolog…
View article: Response to <scp>Impact</scp> of atrial high‐rate episodes and atrial cardiomyopathy on future stroke in patients with dual chamber permanent pacemakers
Response to <span>Impact</span> of atrial high‐rate episodes and atrial cardiomyopathy on future stroke in patients with dual chamber permanent pacemakers Open
We would like to thank Dr. Miyo Nakano et al. for their kind interest in our article "The optimal cutoff of atrial high-rate episodes for neurological events in patients with dual chamber permanent pacemakers".1 As their previous articles,…
View article: HATCH Score and Left Atrial Size Predict Atrial High-Rate Episodes in Patients With Cardiac Implantable Electronic Devices
HATCH Score and Left Atrial Size Predict Atrial High-Rate Episodes in Patients With Cardiac Implantable Electronic Devices Open
Background: Patients with sustained atrial high-rate episodes (AHRE) have a high risk of major adverse cardio/cerebrovascular events (MACCE). However, the prediction model and factors for the occurrence of AHRE are unknown. We aimed to ide…
View article: Atrial high-rate episodes predict major adverse cardio/cerebrovascular events in patients with cardiac implantable electrical devices
Atrial high-rate episodes predict major adverse cardio/cerebrovascular events in patients with cardiac implantable electrical devices Open
Patients with atrial high-rate episodes (AHRE) have a high risk of neurologic events, although the causal role and optimal cutoff threshold of AHRE for major adverse cardio/cerebrovascular events (MACCE) are unknown. This study aimed to id…
View article: The optimal cutoff of atrial high‐rate episodes for neurological events in patients with dual chamber permanent pacemakers
The optimal cutoff of atrial high‐rate episodes for neurological events in patients with dual chamber permanent pacemakers Open
Background Patients with atrial high‐rate episode (AHRE) are at higher risk of neurological events. This study aimed to identify the optimal cutoff threshold for AHRE duration in patients with dual chamber permanent pacemakers (PPM) withou…
View article: Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX‐5461 on pulmonary arterial hypertension and associated vascular remodelling
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX‐5461 on pulmonary arterial hypertension and associated vascular remodelling Open
Background and Purpose CX‐5461 is a novel selective RNA polymerase I (Pol I) inhibitor. Previously, we found that CX‐5461 could inhibit pathological arterial remodelling caused by angioplasty and transplantation. In the present study, we e…
View article: Proteomic Analysis of Aorta and Protective Effects of Grape Seed Procyanidin B2 in db/db Mice Reveal a Critical Role of Milk Fat Globule Epidermal Growth Factor-8 in Diabetic Arterial Damage
Proteomic Analysis of Aorta and Protective Effects of Grape Seed Procyanidin B2 in db/db Mice Reveal a Critical Role of Milk Fat Globule Epidermal Growth Factor-8 in Diabetic Arterial Damage Open
Atherosclerosis is one of the major complications of type 2 diabetic patients (T2DM), leading to morbidity and mortality. Grape seed procyanidin B2 (GSPB2) has demonstrated protective effect against atherosclerosis, which is believed to be…
View article: Asclepius and Yellow Ribbon techniques: Efficacious alternative strategies for advancing a coronary sinus electrophysiology catheter
Asclepius and Yellow Ribbon techniques: Efficacious alternative strategies for advancing a coronary sinus electrophysiology catheter Open
Background Inserting an electrophysiological (EP) catheter into the coronary sinus (CS) via the femoral vein can be difficult and time‐consuming in patients with variants of the CS orifice or lumen curve. Our experience with such patients …
View article: Proposed treatment algorithm for cardiac device-related subclavian vein stenosis: a case series
Proposed treatment algorithm for cardiac device-related subclavian vein stenosis: a case series Open
Background Subclavian vein obstruction may occur in patients with pacemaker leads, which may make the implantation of new pacemaker leads difficult. Case summary We report two cases in which upgrading to cardiac resynchronization therapy p…