Wei‐De Lin
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View article: Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population
Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population Open
This study identified fasting insulin-related loci and developed a PRS model, offering insights into genetic regulation and potential early risk assessment for metabolic diseases in Taiwanese Han population.
View article: Triglyceride glucose index and mortality in tracheally intubated patients: a MIMIC-IV retrospective cohort study
Triglyceride glucose index and mortality in tracheally intubated patients: a MIMIC-IV retrospective cohort study Open
Tracheal intubation is crucial in ICU treatment but poses risks of complications and mortality. Simple and effective indicators for assessing mortality risk in intubated ICU patients are needed. This study analyzed 5,915 intubated ICU pati…
View article: Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study
Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study Open
This study aimed to investigate the relationship between unintentional weight loss and 30-day mortality in sepsis patients in the intensive care unit (ICU). A retrospective cohort study sepsis patients in the ICU was conducted using data f…
View article: Genome-wide association study identifies novel susceptible loci and evaluation of polygenic risk score for chronic obstructive pulmonary disease in a Taiwanese population
Genome-wide association study identifies novel susceptible loci and evaluation of polygenic risk score for chronic obstructive pulmonary disease in a Taiwanese population Open
Background Chronic Obstructive Pulmonary Disease (COPD) describes a group of progressive lung diseases causing breathing difficulties. While COPD development typically involves a complex interplay between genetic and environmental factors,…
View article: Identification of a novel deletion mutation in PHKA2 in a taiwanese patient with type IXa glycogen storage disease
Identification of a novel deletion mutation in PHKA2 in a taiwanese patient with type IXa glycogen storage disease Open
Glycogen, a multi-branched polysaccharide of glucose predominantly stored in muscle and the liver, serves as an endogenous source of energy when the body's glucose level decreases. Glycogen storage diseases (GSDs) are inherited disorders o…
View article: Genetic Testing in Children with Developmental and Epileptic Encephalopathies: A Review of Advances in Epilepsy Genomics
Genetic Testing in Children with Developmental and Epileptic Encephalopathies: A Review of Advances in Epilepsy Genomics Open
Advances in disease-related gene discovery have led to tremendous innovations in the field of epilepsy genetics. Identification of genetic mutations that cause epileptic encephalopathies has opened new avenues for the development of target…
View article: Phenotype and Genotype in a Taiwanese Girl with Sotos Syndrome
Phenotype and Genotype in a Taiwanese Girl with Sotos Syndrome Open
Rare copy number variations have been linked to an important source of mutation in many psychopathological traits and neurodevelopmental disorders. In this study, we describe a Taiwanese girl with mental retardation and mild macrocephaly w…
View article: CD3<sup>+</sup>CD56<sup>+</sup>T Lymphocytes Are Associated With ER Stress and Inflammasome Activation in Type 1 Diabetes
CD3<sup>+</sup>CD56<sup>+</sup>T Lymphocytes Are Associated With ER Stress and Inflammasome Activation in Type 1 Diabetes Open
ER stress, inflammasome activation, and a lower peripheral frequency of circulating CD3+CD56+ T cells might indicate disease progression and necessitate clinical T1D immunological self-tolerance monitoring.
View article: Genetic Analysis of Acid β-Glucosidase in Patients with Multiple Myeloma from Central Taiwan: A Small-Cohort Case-Control Study
Genetic Analysis of Acid β-Glucosidase in Patients with Multiple Myeloma from Central Taiwan: A Small-Cohort Case-Control Study Open
Introduction: Multiple myeloma (MM) is an incurable, biologically heterogeneous disease of the plasma cells, associated with older age and is more common in men. Gaucher disease, caused by mutation in acid β-glucosidase (glucocerebrosidase…
View article: Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study
Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study Open
Febrile seizure (FS) is the most prevalent childhood seizure; it is significantly related to subsequent epilepsy and has possible links to childhood neurodevelopmental disorders. Separately, premature births are believed to increase the ri…
View article: Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study
Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study Open
Acrylamide (ACR), which is formed during the Maillard reaction, is used in various industrial processes. ACR accumulation in humans and laboratory animals results in genotoxicity, carcinogenicity, neurotoxicity, and reproductive toxicity. …
View article: Association Between Kawasaki Disease and Childhood Epilepsy: A Nationwide Cohort Study in Taiwan
Association Between Kawasaki Disease and Childhood Epilepsy: A Nationwide Cohort Study in Taiwan Open
Background: Kawasaki disease is a common vasculitis of childhood in East Asia. The complications following Kawasaki disease mostly included cardiovascular sequelae; non-cardiac complications have been reported but less studied. This study …
View article: NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes
NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes Open
Epigenetics alternation of non-genetic variation and genome-wide association study proven allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development. We analyzed promoter DNA methylation array to evaluate th…
View article: Effects of Multi-Strain Probiotics on Immune Responses and Metabolic Balance in Helicobacter pylori-Infected Mice
Effects of Multi-Strain Probiotics on Immune Responses and Metabolic Balance in Helicobacter pylori-Infected Mice Open
Chronic inflammation caused by Helicobacter pylori infection increases the risk of developing gastric cancer. Even though the prevalence of H. pylori infection has been decreased in many regions, the development of antibiotic resistance st…
View article: Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study
Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study Open
Background: Maternal diabetes mellitus (DM) increases the risk of fetal, neonatal, and long-term complications in offspring. Although this has been widely known for decades, data are limited regarding the effect of maternal pregestational …
View article: Heterogeneous Neurodevelopmental Disorders in Children with Kawasaki Disease: What is New Today?
Heterogeneous Neurodevelopmental Disorders in Children with Kawasaki Disease: What is New Today? Open
Background: Kawasaki disease (KD) is a common vasculitis of childhood in East Asia. The complications of KD ascribed to long-term cardiovascular sequelae are considerably diverse. Although studies have investigated neurodevelopmental probl…
View article: Heterogeneous Neurodevelopmental Disorders in Children with Kawasaki Disease: What is New Today?
Heterogeneous Neurodevelopmental Disorders in Children with Kawasaki Disease: What is New Today? Open
Background Kawasaki disease (KD) is a common vasculitis of childhood in East Asia. The complications of KD ascribed to long-term cardiovascular sequelae are considerably diverse. Although studies have investigated neurodevelopmental proble…
View article: Epilepsy and Neurodevelopmental Outcomes in Children With Etiologically Diagnosed Central Nervous System Infections: A Retrospective Cohort Study
Epilepsy and Neurodevelopmental Outcomes in Children With Etiologically Diagnosed Central Nervous System Infections: A Retrospective Cohort Study Open
Background: Central nervous system (CNS) infection in childhood can lead to neurological sequelae, including epilepsy, and neurodevelopmental disorders, such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (…
View article: Epileptic spasms in PPP1CB-associated Noonan-like syndrome: a case report with clinical and therapeutic implications
Epileptic spasms in PPP1CB-associated Noonan-like syndrome: a case report with clinical and therapeutic implications Open
This result expands the clinical spectrum of NSLH2 and strengthens the association between the PPP1CB gene and epileptic seizures. Furthermore, we suggest that the ketogenic diet can offer seizure reduction in particular drug-resistant epi…
View article: Novel mutations in the cartilage oligomeric matrix protein gene identified in two Taiwanese patients with pseudoachondroplasia and multiple epiphyseal dysplasia
Novel mutations in the cartilage oligomeric matrix protein gene identified in two Taiwanese patients with pseudoachondroplasia and multiple epiphyseal dysplasia Open
Pseudoachondroplasia (PSACH; OMIM 177170) and multiple epiphyseal dysplasia (MED) are skeletal disorders that are characterized by mild to severe short-limb dwarfism and early-onset osteoarthrosis. They are inherited as either autosomal do…