Weifeng Yu
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View article: Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trial
Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trial Open
Liver transplantation remains constrained by the scarcity of donor organs and the risks inherent in the procedure, underscoring the urgent need for novel cirrhosis therapies. We developed a protocol to convert human primary hepatocytes int…
View article: Chinese clinical practice guidelines for total intravenous anaesthesia: a systematic review and expert consensus-based recommendations☆
Chinese clinical practice guidelines for total intravenous anaesthesia: a systematic review and expert consensus-based recommendations☆ Open
View article: Stressors-induced cognitive dysfunction during aging: mechanisms and future challenges
Stressors-induced cognitive dysfunction during aging: mechanisms and future challenges Open
Stressful events can lead to transient impairments in learning and memory, a phenomenon more pronounced in the elderly. As global life expectancy rises, the shift toward an aging society underscores the urgent need for effective preventive…
View article: Author Correction: Morphine promotes non-small cell lung cancer progression by downregulating E-cadherin via the PI3K/AKT/mTOR pathway
Author Correction: Morphine promotes non-small cell lung cancer progression by downregulating E-cadherin via the PI3K/AKT/mTOR pathway Open
View article: Comprehensive pan-cancer analysis reveals CGB5 is a potential promising predictive and immunotherapeutic biomarker
Comprehensive pan-cancer analysis reveals CGB5 is a potential promising predictive and immunotherapeutic biomarker Open
Background Existing studies substantiate the notion that CGB5 plays a pivotal role in various cancers, including gastric and ovarian cancers, and is strongly associated with patient prognosis. However, to date, there have been no comprehen…
View article: The effects of remimazolam on the incidence of severe hypoxemia during sedated hysteroscopy for assisted reproduction in overweight or obese patients: a randomized controlled clinical trial
The effects of remimazolam on the incidence of severe hypoxemia during sedated hysteroscopy for assisted reproduction in overweight or obese patients: a randomized controlled clinical trial Open
View article: The Impact of a Dietary Care Combined with Nutritional Management Model in Elderly Patients with Chronic Heart Failure
The Impact of a Dietary Care Combined with Nutritional Management Model in Elderly Patients with Chronic Heart Failure Open
Background: Chronic heart failure (CHF) is a life-threatening syndrome. Recently, a dietary care combined with nutritional management (DCNM) has become an important component in the management of various diseases. Aim: To investigate the i…
View article: Capnography monitoring reduces incidence of hypoxia in older patients undergoing gastrointestinal endoscopy under propofol sedation
Capnography monitoring reduces incidence of hypoxia in older patients undergoing gastrointestinal endoscopy under propofol sedation Open
Whether routine capnography monitoring during gastrointestinal endoscopy sedation can reduce occurrence of hypoxia is controversial. Older patients are more prone to hypoxia. This study aimed to determine the effect of additional capnograp…
View article: Efficacy of a nasal mask oxygen kit versus regular nasal cannula in sedated gastrointestinal endoscopy: a multicentre, randomised clinical trial
Efficacy of a nasal mask oxygen kit versus regular nasal cannula in sedated gastrointestinal endoscopy: a multicentre, randomised clinical trial Open
Objective The incidence of hypoxia in painless gastrointestinal endoscopy is not negligible. A nasal mask oxygen kit may reduce the incidence of hypoxia compared with a regular nasal cannula. Methods This multi-centre, randomised, open-lab…
View article: Efficacy of high-flow nasal oxygen in preventing hypoxia during Gastrointestinal endoscopy: a retrospective cohort study
Efficacy of high-flow nasal oxygen in preventing hypoxia during Gastrointestinal endoscopy: a retrospective cohort study Open
HFNO emerges as a promising approach for preventing hypoxia during gastrointestinal endoscopy, offering a simple, effective, and non-invasive means of respiratory support.
View article: Cancer and neurotransmitter receptors
Cancer and neurotransmitter receptors Open
In recent years, growing evidence indicates that the nervous system plays an indispensable role in tumor development and metastasis. Elucidating crosstalk between the nervous system and tumor progression has thrived as a hot topic and a ne…
View article: Semaglultide targets Spp1+ microglia/macrophage to attenuate neuroinflammation following perioperative stroke
Semaglultide targets Spp1+ microglia/macrophage to attenuate neuroinflammation following perioperative stroke Open
Peripheral surgery evokes neuroimmune activation in the central nervous system and modulates immune cell polarization in the ischemic brain. However, the phenotypic change of microglia and myeloid cells within post-surgical ischemic brain …
View article: Semaglultide targets Spp1 + microglia/macrophage to attenuate neuroinflammation following perioperative stroke
Semaglultide targets Spp1 + microglia/macrophage to attenuate neuroinflammation following perioperative stroke Open
Peripheral surgery evokes neuroimmune activation in the central nervous system and modulates immune cell polarization in the ischemic brain. However, the phenotypic change of microglia and myeloid cells within post-surgical ischemic brain …
View article: St3gal5-mediated sialylation of glyco-CD177 on neutrophils restricts neuroinflammation following CNS injury
St3gal5-mediated sialylation of glyco-CD177 on neutrophils restricts neuroinflammation following CNS injury Open
Neutrophils are the most abundant circulating leukocyte population that play critical roles in neuroinflammation following central nervous system (CNS) injury. CD177, a glycoprotein on neutrophils, is emerging as an important immune regula…
View article: Comprehensive bibliometric analysis of transcranial magnetic stimulation-based depression treatment from 2003 to 2022: Research hotspots and trends
Comprehensive bibliometric analysis of transcranial magnetic stimulation-based depression treatment from 2003 to 2022: Research hotspots and trends Open
BACKGROUND Depression has become a global public health problem. In recent years, transcranial magnetic stimulation (TMS) has gained considerable attention as a non-invasive treatment for depression. AIM To investigate the research hotspot…
View article: The Causal Relationship Between Gut and Skin Microbiota and Chronic Obstructive Pulmonary Disease:A Bidirectional Two-Sample Mendelian Randomization Analysis
The Causal Relationship Between Gut and Skin Microbiota and Chronic Obstructive Pulmonary Disease:A Bidirectional Two-Sample Mendelian Randomization Analysis Open
This study revealed the causal relationships between gut and skin microbiota and COPD, offering fresh perspectives for the prevention, diagnosis, and management of COPD.
View article: Knowledge, attitudes and practices of <scp>ICU</scp> nurses regarding postextubation dysphagia in tracheal intubation patients in 25 hospitals in China: A multicentre cross‐sectional survey
Knowledge, attitudes and practices of <span>ICU</span> nurses regarding postextubation dysphagia in tracheal intubation patients in 25 hospitals in China: A multicentre cross‐sectional survey Open
Background Postextubation dysphagia is common in the ICU, with varying incidence rates. However, few studies have focused on ICU nurses' knowledge, attitudes and practices regarding postextubation dysphagia, as well as the various influenc…
View article: Inhibition of liver cancer cell growth by metabolites S-adenosylmethionine and nicotinic acid originating from liver progenitor cells
Inhibition of liver cancer cell growth by metabolites S-adenosylmethionine and nicotinic acid originating from liver progenitor cells Open
View article: Dezocine modulates the reinstatement of conditioned place preference in morphine-dependent rats via the dopamine reward circuitry
Dezocine modulates the reinstatement of conditioned place preference in morphine-dependent rats via the dopamine reward circuitry Open
Introduction Opioid addiction is a significant public health issue, with existing treatments such as buprenorphine and methadone exhibiting limitations, including side effects and insufficient prevention of relapse. Novel therapeutic strat…
View article: Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells
Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells Open
Background: Cell therapy demonstrates promising potential as a substitute therapeutic approach for liver cirrhosis. We have developed a strategy to effectively expand murine and human hepatocyte-derived liver progenitor-like cells (HepLPCs…
View article: Cerebral tissue oxygen saturation and its potential relationship with neurodevelopmental delay in pediatric liver transplant recipients
Cerebral tissue oxygen saturation and its potential relationship with neurodevelopmental delay in pediatric liver transplant recipients Open
Objective To discover the potential association between diminished intraoperative average SctO 2 levels and postoperative neurodevelopmental delays among patients after pediatric living-donor liver transplantation. Study design Patients un…
View article: Comparison of the analgesic efficacy of ultrasound-guided retrolaminar block with serratus anterior plane block in patients undergoing radical mastectomy
Comparison of the analgesic efficacy of ultrasound-guided retrolaminar block with serratus anterior plane block in patients undergoing radical mastectomy Open
Retrolaminar block and Serratus anterior plane block provide comparable postoperative analgesia following radical mastectomy. However, RLB offers a broader sensory block range, particularly over the medial chest wall.
View article: Efficacy and Safety of Jianpi Liqi Granules for Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Study
Efficacy and Safety of Jianpi Liqi Granules for Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Study Open
View article: Human liver progenitor-like cells-derived extracellular vesicles promote liver regeneration during acute liver failure
Human liver progenitor-like cells-derived extracellular vesicles promote liver regeneration during acute liver failure Open
Hepatocyte-derived liver progenitor-like cells (HepLPCs) exhibit a remarkable capacity to support liver function by detoxifying ammonia, promoting native liver regeneration, and suppressing inflammation, which leads to improvements in the …
View article: A brain-to-liver signal mediates the inhibition of liver regeneration under chronic stress in mice
A brain-to-liver signal mediates the inhibition of liver regeneration under chronic stress in mice Open
View article: Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment
Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment Open
View article: Similarities and differences in the response and molecular characteristics of peripheral sensory neurons associated with pain and itch
Similarities and differences in the response and molecular characteristics of peripheral sensory neurons associated with pain and itch Open
Dorsal root ganglion (DRG) neurons are responsible for the primary detection and transmission of peripheral noxious stimuli, mainly pain and itch. However, as two distinct noxious sensations, how DRG neurons respond differently to and code…
View article: The peripheral Atf3&lt;sup&gt;+&lt;/sup&gt; neuronal population is responsible for nerve regeneration at the early stage of nerve injury revealed by single-cell RNA sequencing
The peripheral Atf3<sup>+</sup> neuronal population is responsible for nerve regeneration at the early stage of nerve injury revealed by single-cell RNA sequencing Open
Peripheral nerve injury (PNI) can transform primary somatosensory neurons to a regenerative state. However, the details of the transcriptomic changes associated with the nerve regeneration of somatosensory neurons remain unclear. In this s…
View article: Morphine promotes non-small cell lung cancer progression by downregulating E-cadherin via the PI3K/AKT/mTOR pathway
Morphine promotes non-small cell lung cancer progression by downregulating E-cadherin via the PI3K/AKT/mTOR pathway Open
View article: Research trends and hotspots on osteoporosis: a decade-long bibliometric and visualization analysis from 2014 to 2023
Research trends and hotspots on osteoporosis: a decade-long bibliometric and visualization analysis from 2014 to 2023 Open
Background Osteoporosis is characterized by diminished bone density and quality, compromised bone microstructure, and increased bone fragility, culminating in a heightened risk of fracture. Relatively few attempts have been made to survey …