Weigang Guo
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View article: Metabolism-driven posttranslational modifications and immune regulation: Emerging targets for immunotherapy
Metabolism-driven posttranslational modifications and immune regulation: Emerging targets for immunotherapy Open
The interplay between cellular metabolism and immune regulation is central to immune function and disease progression, revealing notable therapeutic opportunities. Upon activation, immune cells undergo metabolic reprogramming to meet heigh…
View article: KLF13 promotes ferroptosis and chemosensitivity in lung adenocarcinoma
KLF13 promotes ferroptosis and chemosensitivity in lung adenocarcinoma Open
Our study reveals that KLF13 promotes ferroptosis in LUAD by inhibiting GPX4, thereby enhancing sensitivity to chemotherapy drugs. Overall, targeting KLF13 may contribute to developing new therapeutic strategies for LUAD.
View article: NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment
NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment Open
Lung adenocarcinoma (LUAD) is a leading cause of cancer‐related mortality, with the tumor microenvironment (TME) playing a critical role in its progression. Metabolic reprogramming, particularly lactate accumulation, drives immune suppress…
View article: <scp>miR</scp>‐30c‐5p inhibits esophageal squamous cell carcinoma progression by repressing the <scp>PI3K</scp>/<scp>AKT</scp> signaling pathway
<span>miR</span>‐30c‐5p inhibits esophageal squamous cell carcinoma progression by repressing the <span>PI3K</span>/<span>AKT</span> signaling pathway Open
Background Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors, with high incidence and poor prognosis. Revealing mechanisms of ESCC progression and developing new therapeutic targets remains crucial. The a…
View article: The associations between dysregulation of human blood metabolites and lung cancer risk: evidence from genetic data
The associations between dysregulation of human blood metabolites and lung cancer risk: evidence from genetic data Open
Background Metabolic dysregulation is recognized as a significant hallmark of cancer progression. Although numerous studies have linked specific metabolic pathways to cancer incidence, the causal relationship between blood metabolites and …
View article: Epidemiological characteristics and therapeutic advances of <scp>EGFR</scp> exon 20 insertion mutations in non‐small cell lung cancer
Epidemiological characteristics and therapeutic advances of <span>EGFR</span> exon 20 insertion mutations in non‐small cell lung cancer Open
The third most prevalent type of epidermal growth factor receptor ( EGFR ) mutation, EGFR exon 20 insertions (EGFRex20ins), involves 2%–12% of all cases of EGFR‐positive non‐small cell lung cancer (NSCLC). Approximately 90% of the mutation…
View article: Clinicopathological and prognostic implications of <scp>ALK</scp> rearrangement in patients with completely surgically resected lung adenocarcinoma
Clinicopathological and prognostic implications of <span>ALK</span> rearrangement in patients with completely surgically resected lung adenocarcinoma Open
Background The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these p…
View article: Development and validation of a nomogram for predicting the overall survival of patients with lung large cell neuroendocrine carcinoma
Development and validation of a nomogram for predicting the overall survival of patients with lung large cell neuroendocrine carcinoma Open
The nomogram demonstrated its discrimination capability to predict the OS for L-LCNEC patients.
View article: Long-term outcomes following neoadjuvant or adjuvant chemoradiotherapy for stage I–IIIA non-small cell lung cancer: a propensity-matched analysis
Long-term outcomes following neoadjuvant or adjuvant chemoradiotherapy for stage I–IIIA non-small cell lung cancer: a propensity-matched analysis Open
Neoadjuvant chemoradiotherapy might improve the long-term survival of patients with stage I-IIIA non-small cell lung cancer (NSCLC). For patients aged more than 75 years, neoadjuvant chemoradiotherapy was not associated with an improvement…
View article: A nomogram to predict prognosis of patients with lung adenosquamous carcinoma: a population-based study
A nomogram to predict prognosis of patients with lung adenosquamous carcinoma: a population-based study Open
BACKGROUND: Adenosquamous carcinoma (ASC) of the lung is an infrequent variant of lung cancer. This study aimed to identify independent risk factors and to develop a predictive model for the prognosis of ASC patients. METHODS: Patient data…
View article: Benefits of surgery in the multimodality treatment of stage IIB-IIIC small cell lung cancer
Benefits of surgery in the multimodality treatment of stage IIB-IIIC small cell lung cancer Open
Surgery combined with chemotherapy/radiotherapy is recommended for early stage small cell lung cancer (SCLC); however, the role of surgery in the multimodality treatment of advanced disease remains controversial. The clinical data of patie…
View article: [Clinical Characteristics and Prognostic Factors of Lung Adenosquamous Carcinoma
in SEER Database between 2010 and 2015].
[Clinical Characteristics and Prognostic Factors of Lung Adenosquamous Carcinoma
in SEER Database between 2010 and 2015]. Open
Lung adenosquamous carcinoma has unique clinical, pathological, and prognostic characteristics. Age, differentiation, T, N, M, surgery, and chemotherapy status are independent predictors of prognosis in patients with adenosquamous carcinom…
View article: Evaluation of the 7th edition of the UICC-AJCC tumor, node, metastasis classification for esophageal cancer in a Chinese cohort
Evaluation of the 7th edition of the UICC-AJCC tumor, node, metastasis classification for esophageal cancer in a Chinese cohort Open
The 7(th) edition of AJCC TNM staging system of esophageal cancer should discriminate pT2-3N0M0 (stage IB, IIA and IIB) better when considering the esophageal squamous cell cancer patients. Therefore, to improve and optimize the AJCC TNM c…