Wei‐Guang Wang
YOU?
Author Swipe
View article: CCDC 2502394: Experimental Crystal Structure Determination
CCDC 2502394: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: How to enhance the effectiveness of chian ’ s digital healthcare system through organizational optimization and economic resource allocation
How to enhance the effectiveness of chian ’ s digital healthcare system through organizational optimization and economic resource allocation Open
The construction of China's digital healthcare system faces multiple challenges, such as the interest coordination dilemma within the "tripartite synergy of doctors" mechanism, uneven resource allocation, and incomplete policies and regula…
View article: CCDC 2453286: Experimental Crystal Structure Determination
CCDC 2453286: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Effectiveness and Safety of Polatuzumab Vedotin Plus an Anti‐CD20 Monoclonal Antibody (Rituximab or Obinutuzumab) and Zanubrutinib in Relapsed/Refractory Diffuse Large B‐Cell Lymphoma
Effectiveness and Safety of Polatuzumab Vedotin Plus an Anti‐CD20 Monoclonal Antibody (Rituximab or Obinutuzumab) and Zanubrutinib in Relapsed/Refractory Diffuse Large B‐Cell Lymphoma Open
Background Approximately 30% of patients with diffuse large B‐cell lymphoma (DLBCL) relapse or are refractory to first‐line treatment. This study aimed to determine the effectiveness and tolerability of the combination of Polatuzumab vedot…
View article: Pola-R-CHP performed well in first-line Polarix trial-ineligible and IPI 0–1 DLBCL patients
Pola-R-CHP performed well in first-line Polarix trial-ineligible and IPI 0–1 DLBCL patients Open
Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) improved progression-free survival (PFS) of diffuse large B-cell lymphoma (DLBCL) in Polarix study. But little evidence has been provided for patien…
View article: Unraveling the microbiome–aroma Nexus: a metagenomic and volatile compound analysis of Yunnan cigars
Unraveling the microbiome–aroma Nexus: a metagenomic and volatile compound analysis of Yunnan cigars Open
Introduction Understanding how microbial communities influence aroma profiles is critical to improving cigar quality. However, comparative studies examining the microbiome–aroma nexus across major cigar-producing regions remain limited. Me…
View article: Aromatic sesquiterpenes isolated from high-trichome sun-cured tobacco as potential activators for powdery mildew
Aromatic sesquiterpenes isolated from high-trichome sun-cured tobacco as potential activators for powdery mildew Open
Background: Powdery mildew is a fungal disease threatening major global crops such as tobacco, rice, and grapes. Pathogens cause severe yield losses by disrupting photosynthesis and inducing premature plant senescence. Traditional chemical…
View article: Universal in situ supersaturated crystallization enables 3D printable afterglow hydrogel
Universal in situ supersaturated crystallization enables 3D printable afterglow hydrogel Open
Stretchable afterglow materials have garnered widespread attention owing to their unique combination of optical properties and mechanical flexibility. However, achieving a crystal environment to suppress the non-radiative transition of tri…
View article: Cyclization diversity of meroditerpenoids from endophytic fungi of medicinal plants driven by synthetic biology strategies
Cyclization diversity of meroditerpenoids from endophytic fungi of medicinal plants driven by synthetic biology strategies Open
Background Medicinal plants rich in endophytic fungi are a significant source of natural lead compounds. Meroterpenoids, which are hybrid natural products originating from partially terpenoid pathways, exhibit impressive structural complex…
View article: High perioperative lactate levels as a potential predictor for severe acute kidney injury following aortic arch surgery
High perioperative lactate levels as a potential predictor for severe acute kidney injury following aortic arch surgery Open
Background Acute type A aortic dissection (ATAAD) is a life-threatening condition that often requires total aortic arch replacement (TAR) combined with frozen elephant trunk (FET) implantation. Despite advancements in surgical techniques a…
View article: Genome-Driven Discovery of Antiviral Atralabdans A–C from the Soil-Dwelling <i>Streptomyces atratus</i>
Genome-Driven Discovery of Antiviral Atralabdans A–C from the Soil-Dwelling <i>Streptomyces atratus</i> Open
Heterologous expression of an atr terpenoid gene cluster derived from Streptomyces atratus Gö66 in S. albus J1074 led to the discovery of three novel labdane diterpenoids featuring an unprecedented 6/6/5-fused tricycli…
View article: Structural and Computational Insights into the Noncanonical Aromatization in Fungal Polyketide Biosynthesis
Structural and Computational Insights into the Noncanonical Aromatization in Fungal Polyketide Biosynthesis Open
View article: Recent progress on exciplex-based organic long-persistence luminescent materials
Recent progress on exciplex-based organic long-persistence luminescent materials Open
纯有机长余辉材料具有分子结构/功能可调、易加工、不含重金属元素、生物相容性好、可大面积应用以及柔性等优点,在数据加密、生物成像、安全打印等领域得到了广泛的应用,是目前有机光电子学研究的热点之一。基于给体-受体构建的激基复合物长余辉材料具有发光持续时间长、制备简便以及性能可调等优点,成为设计、开发有机长余辉材料的新选择,近年来受到了人们的广泛关注。本文系统地综述了给-受体激基复合物长余辉材料的基本设计理念,并依据受体材料的不同,详细总结了各类高效、稳定的激基复合物长余辉材料体…
View article: Enabling robust blue circularly polarized organic afterglow through self-confining isolated chiral chromophore
Enabling robust blue circularly polarized organic afterglow through self-confining isolated chiral chromophore Open
View article: Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A
Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A Open
Thielavin A ( 1 ) is a fungal depside composed of one 3‐methylorsellinic acid and two 3,5‐dimethylorsellinic acid units. It displays diverse biological activities. However, the mechanism underlying the assembly of the heterotrimeric struct…
View article: Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A
Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A Open
Thielavin A ( 1 ) is a fungal depside composed of one 3‐methylorsellinic acid and two 3,5‐dimethylorsellinic acid units. It displays diverse biological activities. However, the mechanism underlying the assembly of the heterotrimeric struct…
View article: Effects of aerobic exercise on cognitive function in adults with major depressive disorder: A systematic review and meta-analysis
Effects of aerobic exercise on cognitive function in adults with major depressive disorder: A systematic review and meta-analysis Open
View article: Integrative analysis reveals chemokines CCL2 and CXCL5 mediated shear stress-induced aortic dissection formation
Integrative analysis reveals chemokines CCL2 and CXCL5 mediated shear stress-induced aortic dissection formation Open
Through integrative analysis, we identified core common AD DEGs and possible therapeutic agents based on these DEGs. We elucidated that the chemokine CCL2 and CXCL5-mediated "Endothelial-Monocyte-Neutrophil" axis may contribute to the deve…
View article: Characterization of anti-TMV indole alkaloid and isocoumarin derivatives from Aspergillus versicolor YNCA0363
Characterization of anti-TMV indole alkaloid and isocoumarin derivatives from Aspergillus versicolor YNCA0363 Open
Background Tobacco mosaic virus (TMV) is a harmful plant pathogen that causes a decline in the quality and yield of many economic crops. Natural products are important potential sources of biopesticides for the prevention and treatment of …
View article: Developing stable organic radical anions to achieve long persistent luminescence for afterglow lighting
Developing stable organic radical anions to achieve long persistent luminescence for afterglow lighting Open
View article: Prenylated flavonoids isolated from the twigs of Artocarpus champeden as potential activators for tobacco powdery mildew and their mode of actions
Prenylated flavonoids isolated from the twigs of Artocarpus champeden as potential activators for tobacco powdery mildew and their mode of actions Open
Background Golovinomyces cichoracearum (DC.) is the main pathogen for tobacco powdery mildew fungus disease. Its outbreaks often result in severe harvest losses for the yield and quality of tobacco. Artocarpus champeden is rich in prenylat…
View article: Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis
Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis Open
Alkyl salicylaldehyde derivatives are polyketide natural products, which are widely distributed in fungi and exhibit great structural diversity. Their biosynthetic mechanisms have recently been intensively studied; however, how the polyket…
View article: Data from The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects
Data from The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects Open
Aberrant expression of thioredoxin 1 (Trx1) plays an important role in cancer initiation and progression and has gained attention as an anticancer drug target. Here we report that the recently discovered natural diterpenoid isoforretin A (…
View article: Data from The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects
Data from The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects Open
Aberrant expression of thioredoxin 1 (Trx1) plays an important role in cancer initiation and progression and has gained attention as an anticancer drug target. Here we report that the recently discovered natural diterpenoid isoforretin A (…
View article: Supplementary Materials and Methods from The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects
Supplementary Materials and Methods from The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects Open
This doctment contains supplementary methods and results of the following contents: Firstly, the isolation and conformational analysis of IsoA. Secondly, IsoA inhibited the cologenic formation in a panel of cell lines. Thirdly, IsoA induce…
View article: Supplementary Materials and Methods from The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects
Supplementary Materials and Methods from The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects Open
This doctment contains supplementary methods and results of the following contents: Firstly, the isolation and conformational analysis of IsoA. Secondly, IsoA inhibited the cologenic formation in a panel of cell lines. Thirdly, IsoA induce…
View article: Cytotoxic sesquiterpene aryl esters from Armillaria gallica 012m
Cytotoxic sesquiterpene aryl esters from Armillaria gallica 012m Open
View article: Antivirus isoindolinone alkaloids with rare oxocyclopenta[f]isoindole frameworks isolated from the stems of flue cured tobacco
Antivirus isoindolinone alkaloids with rare oxocyclopenta[f]isoindole frameworks isolated from the stems of flue cured tobacco Open
Background Since Nicotiana tabacum (tobacco) has important significance to humans for their medicinal uses, to find antivirus activities inhibitors from tobacco, increase its medicinal value, and comprehensive utilization of its by-product…
View article: Study on Stability and Control of Surrounding Rock in the Stopping Space with Fully Mechanized Top Coal Caving under Goaf
Study on Stability and Control of Surrounding Rock in the Stopping Space with Fully Mechanized Top Coal Caving under Goaf Open
Under the condition of fully mechanized top coal caving in close-distance coal seams, the surrounding rock of the stopping space easily loses stability during the withdrawal of mining equipment in the working face because the lower coal se…
View article: Anti-Virus Isoindolinone alkaloids with rare oxocyclopenta[f]isoindole frameworks isolated from the stems of flue cured tobacco
Anti-Virus Isoindolinone alkaloids with rare oxocyclopenta[f]isoindole frameworks isolated from the stems of flue cured tobacco Open
Background The large scale tobacco planting in Yunnan produces a large amount of waste, including stems, roots, low grade and defective tobacco leaves. Therefore, the multipurpose utilization of the by-product of tobacco is an interesting …