Weihai Ying
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View article: Acupuncture for the anxiety and depression in Parkinson disease: A systematic review and network meta-analysis
Acupuncture for the anxiety and depression in Parkinson disease: A systematic review and network meta-analysis Open
Background: Parkinson disease (PD) is characterized by motor symptoms as the main clinical manifestation. Emotional symptoms such as anxiety and depression are often closely related to the severity of the disease in Parkinson disease patie…
View article: Decreased green autofluorescence in cancerous tissues is a potential biomarker for diagnosis of renal cell carcinomas
Decreased green autofluorescence in cancerous tissues is a potential biomarker for diagnosis of renal cell carcinomas Open
View article: The optimization and application of photodynamic diagnosis and autofluorescence imaging in tumor diagnosis and guided surgery: current status and future prospects
The optimization and application of photodynamic diagnosis and autofluorescence imaging in tumor diagnosis and guided surgery: current status and future prospects Open
Photodynamic diagnosis (PDD) and autofluorescence imaging (AFI) are emerging cancer diagnostic technologies that offer significant advantages over traditional white-light endoscopy in detecting precancerous lesions and early-stage cancers;…
View article: Methylene blue reduces the serum levels of interleukin-6 and inhibits STAT3 activation in the brain and the skin of lipopolysaccharide-administered mice
Methylene blue reduces the serum levels of interleukin-6 and inhibits STAT3 activation in the brain and the skin of lipopolysaccharide-administered mice Open
It is valuable to search for novel and economical agents for inhibiting STAT3 activation and blocking increases in IL-6 levels, due to the important roles of STAT3 and IL-6 in inflammation. Since Methylene Blue (MB) has shown therapeutical…
View article: Phenomic Studies on Diseases: Potential and Challenges
Phenomic Studies on Diseases: Potential and Challenges Open
View article: NAD<sup>+</sup> administration profoundly decreases UVC-induced skin damage by attenuating oxidative stress, inflammation, DNA damage and apoptosis.
NAD<sup>+</sup> administration profoundly decreases UVC-induced skin damage by attenuating oxidative stress, inflammation, DNA damage and apoptosis. Open
Ultraviolet (UV) radiation is a major cause of multiple major skin diseases including skin cancer. It is crucial to discover new agents that can produce profound protective effects on UV-produced skin damage. Using a mouse model, in this s…
View article: A Comprehensive Study of De Novo Mutations on the Protein-Protein Interaction Interfaces Provides New Insights into Developmental Delay
A Comprehensive Study of De Novo Mutations on the Protein-Protein Interaction Interfaces Provides New Insights into Developmental Delay Open
Mutations, especially those at the protein-protein interaction (PPI) interface, have been associated with various diseases. Meanwhile, though de novo mutations (DNMs) have been proven important in neuropsychiatric disorders, such as develo…
View article: A Comprehensive Study of De Novo Mutations on Protein-protein Interaction Interface Provides New Insights in Developmental Delay
A Comprehensive Study of De Novo Mutations on Protein-protein Interaction Interface Provides New Insights in Developmental Delay Open
Mutations, especially those at the protein-protein interaction (PPI) interface, have been associated with various diseases. Meanwhile, though de novo mutations (DNMs) have been proven important in neuropsychiatric disorders, such as develo…
View article: Koisio Technology-Modulated Cell Culture Media can Significantly Increase the Antioxidant Capacity of Mouse Fibroblasts
Koisio Technology-Modulated Cell Culture Media can Significantly Increase the Antioxidant Capacity of Mouse Fibroblasts Open
Oxidative stress is not only a critical common pathological factor of numerous diseases, but also an important factor in the aging process. It is highly valuable to discover novel and economic substances for enhancing the antioxidant capac…
View article: Differential Effects of Koisio Technology-Modulated Solutions on the Growth of Lung Fibroblast Cell Cultures and Lung Cancer Cell Cultures
Differential Effects of Koisio Technology-Modulated Solutions on the Growth of Lung Fibroblast Cell Cultures and Lung Cancer Cell Cultures Open
Cell growth is a crucial biological property of cells, which plays key roles in several major biological processes including organ development, tissue repair and cancer development. It is of both scientific and medical significance to disc…
View article: Koisio Technology-Modulated Cell Culture Media can Lead to Markedly Increased Intracellular ATP Levels of Fibroblast Cell Cultures
Koisio Technology-Modulated Cell Culture Media can Lead to Markedly Increased Intracellular ATP Levels of Fibroblast Cell Cultures Open
It has been reported that Koisio technology-modulated water without external additions of any substances can enter several types of aquaporins with significantly higher rate. In this study we determined the effects of Koisio technology-mod…
View article: Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation
Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation Open
Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD + /NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a …
View article: Peer Review #1 of "Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells (v0.1)"
Peer Review #1 of "Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells (v0.1)" Open
Background.Multiple studies have indicated crucial roles of NAD + deficiency in several neurological diseases and aging.It is critical to discover the mechanisms underlying the NAD + deficiency.Decreased level of Nicotinamide phosphoribosy…
View article: Peer Review #1 of "Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells (v0.2)"
Peer Review #1 of "Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells (v0.2)" Open
Background.Multiple studies have indicated crucial roles of NAD + deficiency in several neurological diseases and aging.It is critical to discover the mechanisms underlying the NAD + deficiency.Decreased level of Nicotinamide phosphoribosy…
View article: Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells
Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells Open
Background. Multiple studies have indicated crucial roles of NAD + deficiency in several neurological diseases and aging. It is critical to discover the mechanisms underlying the NAD + deficiency. A decreased level of Nicotinamide phosphor…
View article: Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study
Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study Open
Testosterone’s role in female depression is not well understood, with studies reporting conflicting results. Here, we use meta-analytical and Mendelian randomization techniques to determine whether serum testosterone levels differ between …
View article: Intracellular Oxidative Stress Levels are Significantly Associated with the Green Autofluorescence Intensity of Buthionine Sulfoximine-Treated B16-F10 Cells
Intracellular Oxidative Stress Levels are Significantly Associated with the Green Autofluorescence Intensity of Buthionine Sulfoximine-Treated B16-F10 Cells Open
Since oxidative stress is a critical common pathological factor of numerous diseases, it is critical to find biomarkers for non-invasive evaluations of the levels of oxidative stress in the body. Our previous studies have indicated that ep…
View article: Keratin 1 plays significant roles in maintaining the survival and oxidative stress state of B16-F10 melanoma cell lines.
Keratin 1 plays significant roles in maintaining the survival and oxidative stress state of B16-F10 melanoma cell lines. Open
Keratins play multiple significant biological roles in epithelium. Keratin 1 (K1)/keratin 10 (K10) heterodimer is a hallmark for keratinocyte differentiation. While keratins are absent in normal melanocyte, keratins have been found in both…
View article: Growth stage-dependent changes of the levels of keratin 1 and keratin 10 as well as skin’s green autofluorescence of the back and the ears of C57BL/6 mice under basal conditions and after UVC irradiation
Growth stage-dependent changes of the levels of keratin 1 and keratin 10 as well as skin’s green autofluorescence of the back and the ears of C57BL/6 mice under basal conditions and after UVC irradiation Open
Our previous studies have indicated that oxidative stress and inflammation can dose-dependently induce increased skin’s green autofluorescence (AF) of mice, which results at least partially from keratin 1 (K1) cleavage. Increased green AF …
View article: Inflammation mediates lung cancer-induced increase in the epidermal green autofluorescence of mice
Inflammation mediates lung cancer-induced increase in the epidermal green autofluorescence of mice Open
Skin’s autofluorescence (AF) holds great promise for non-invasive diagnosis of diseases. Our previous study has indicated that keratin-based skin’s AF holds great promise to become a novel biomarker for diagnosis of multiple major diseases…
View article: Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in PC12 cells
Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in PC12 cells Open
Numerous studies have indicated critical roles of NAD + deficiency in both aging and multiple major diseases. It is critical to investigate the mechanisms underlying the NAD + deficiency under the pathological conditions. It has been repor…
View article: Smoking is associated with significantly increased green autofluorescence intensity and asymmetry of the skin and the fingernails of natural populations, population at-risk of developing stroke, and population of acute ischemic stroke
Smoking is associated with significantly increased green autofluorescence intensity and asymmetry of the skin and the fingernails of natural populations, population at-risk of developing stroke, and population of acute ischemic stroke Open
Tobacco smoking is an important risk factor for multiple major diseases including cancer and stroke. It is of significance to search for the biomarkers of smoking for non-invasive, rapid and economic monitoring of the pathological changes …
View article: A Mild Keratin 1 Decrease Leads to Cell Death and Increased Oxidative Stress in B16-F10 Melanoma Cell Lines
A Mild Keratin 1 Decrease Leads to Cell Death and Increased Oxidative Stress in B16-F10 Melanoma Cell Lines Open
Keratins play multiple significant biological roles in epithelium. K1 / keratin 10 (K10) heterodimer is a hallmarker for keratinocyte differentiation. While keratins are absent in normal melanocyte, keratins have been found in both melanom…
View article: Mitochondrial Electron Transport Chain Inhibition Suppresses LPS-Induced Inflammatory Responses via TREM1/STAT3 Pathway in BV2 Microglia
Mitochondrial Electron Transport Chain Inhibition Suppresses LPS-Induced Inflammatory Responses via TREM1/STAT3 Pathway in BV2 Microglia Open
Mitochondrial damage and neuroinflammation belong to two of the most important pathological factors in multiple neurological disorders. However, the effect of mitochondrial damage of microglia on microglial activation under pathological co…
View article: Epidermal green autofluorescence intensity is significantly associated with the serum levels of multiple cytokines of LPS-exposed mice
Epidermal green autofluorescence intensity is significantly associated with the serum levels of multiple cytokines of LPS-exposed mice Open
Inflammation plays various crucial pathological and physiological roles, in which a number of pro-inflammatory and anti-inflammatory cytokines are important mediators. It is of great scientific and clinical significance to search for non-i…
View article: Cryptotanshinone Attenuates Inflammatory Response of Microglial Cells via the Nrf2/HO-1 Pathway
Cryptotanshinone Attenuates Inflammatory Response of Microglial Cells via the Nrf2/HO-1 Pathway Open
Cryptotanshinone (CTN), a monomer compound extracted from the dried roots and rhizomes of Salvia miltiorrhiza Bge, has a variety of pharmacological effects. However, little research has been done on the mechanism of CTN in attenuati…
View article: SIRT2, ERK and Nrf2 Mediate NAD+ Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions
SIRT2, ERK and Nrf2 Mediate NAD+ Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions Open
NAD+ (oxidized form of nicotinamide adenine dinucleotide) administration is highly beneficial in numerous models of diseases and aging. It is becoming increasingly important to determine if NAD+ treatment may directly…
View article: Keratin-Based Epidermal Green Autofluorescence is a Common Biomarker of Organ Injury
Keratin-Based Epidermal Green Autofluorescence is a Common Biomarker of Organ Injury Open
It is critical to discover biomarkers for non-invasive evaluation of the levels of inflammation and oxidative stress in human body - two key pathological factors in numerous diseases. Our study has indicated keratin 1-based epidermal autof…
View article: The green autofluorescence intensity and asymmetry of older men is significantly higher than those of older women in their fingernails and certain regions of skin
The green autofluorescence intensity and asymmetry of older men is significantly higher than those of older women in their fingernails and certain regions of skin Open
Our recent studies have suggested that the patients of multiple diseases have characteristic Pattern of Autofluorescence (AF) in their skin and fingernails, which may become novel biomarkers for both disease diagnosis and evaluation of hea…
View article: Lipopolysaccharide (LPS) induces increased epidermal green autofluorescence of mouse
Lipopolysaccharide (LPS) induces increased epidermal green autofluorescence of mouse Open
Our recent studies have suggested that characteristic ‘Pattern of Autofluorescence (AF)’ of each disease could be a novel biomarker for non-invasive diagnosis of multiple major diseases such as acute ischemic stroke. It is necessary to det…