Weiheng Chen
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View article: Secretome from human placenta-derived mesenchymal stem cells repairs mechanically induced meniscus injury in mice by activating the proliferation and suppressing the apoptosis of endogenous meniscus progenitor cells
Secretome from human placenta-derived mesenchymal stem cells repairs mechanically induced meniscus injury in mice by activating the proliferation and suppressing the apoptosis of endogenous meniscus progenitor cells Open
Background Meniscus diseases present certain therapeutic limitations. Although meniscectomy is the primary treatment option for meniscus injury (MI), this approach may accelerate the development of osteoarthritis and other degenerative joi…
View article: Bushen Zhuanggu Formula promotes bone repair in nontraumatic osteonecrosis of the femoral head via regulating PKC-RAS-ERK-ETS1-RANKL signaling axis
Bushen Zhuanggu Formula promotes bone repair in nontraumatic osteonecrosis of the femoral head via regulating PKC-RAS-ERK-ETS1-RANKL signaling axis Open
Background: Bushen Zhuanggu Formula (BZF), derived from the classic Yougui Pills, has shown favorable clinical efficacy in treating advanced nontraumatic osteonecrosis of the femoral head (NONFH), particularly by promoting bone repair. How…
View article: Construction and Practical Research on Intelligent Management Model of Training Rooms in Higher Vocational Colleges Driven by Artificial Intelligence
Construction and Practical Research on Intelligent Management Model of Training Rooms in Higher Vocational Colleges Driven by Artificial Intelligence Open
China’s vocational colleges have a hard time with room management, mainly due to ineffective scheduling, unused resources and not enough technology. Artificial intelligence is providing a useful answer to these difficulties with intelligen…
View article: Causal association between sarcopenia-related traits and osteoarthritis: A bidirectional 2-sample Mendelian randomization Study
Causal association between sarcopenia-related traits and osteoarthritis: A bidirectional 2-sample Mendelian randomization Study Open
Accumulating evidence from observational studies indicated that sarcopenia and osteoarthritis (OA) may interact in pathomechanism. Therefore, the present 2-sample Mendelian randomization (MR) study aimed to reveal the bidirectional causal …
View article: Comorbidity profiles and treatment patterns of osteoarthritis patients in Beijing: A cross-sectional study based on community medical records
Comorbidity profiles and treatment patterns of osteoarthritis patients in Beijing: A cross-sectional study based on community medical records Open
Background: Osteoarthritis (OA) is a chronic disabling condition and a common comorbidity in the elderly. Community health centres in China serve as a key setting for the long-term, personalized management of OA and comorbidities. Objectiv…
View article: Long‐Term Cycling Stability and Dendrite Suppression in Garnet‐Type Solid‐State Lithium Batteries via Plasma‐Induced Artificial SEI Layer Formation
Long‐Term Cycling Stability and Dendrite Suppression in Garnet‐Type Solid‐State Lithium Batteries via Plasma‐Induced Artificial SEI Layer Formation Open
The garnet‐based solid‐state‐electrolyte Li 6.5 La 3 Zr 1.5 Ta 0.5 O 12 (LLZTO) faces challenges due to its poor contact with Li‐metal, resulting in high interfacial‐resistance and dendrite growth. To address this, an SnO 2 ‐Al (SA) ultra‐…
View article: Relationship between anterior or posterior femoral head necrosis and collapse based on MRI-defined key necrotic layer sets
Relationship between anterior or posterior femoral head necrosis and collapse based on MRI-defined key necrotic layer sets Open
In MRI, the anterior side of the femoral head corresponds to the S3 region, where necrosis increases the risk of collapse by 11.4 times.
View article: Osteoking exerts pro‑osteogenic and anti‑adipogenic effects in promoting bone fracture healing via EGF/EGFR/HDAC1/Wnt/β‑catenin signaling
Osteoking exerts pro‑osteogenic and anti‑adipogenic effects in promoting bone fracture healing via EGF/EGFR/HDAC1/Wnt/β‑catenin signaling Open
Bone fractures, as a global public health issue, lead to disability and reduce the quality of life for patients. Chinese patent drug Osteoking has efficacy in bone fracture therapy. However, its therapeutic properties and underlying mechan…
View article: Hip joint-preserving strategies for treating osteonecrosis of the femoral head: From nonoperative to operative procedures
Hip joint-preserving strategies for treating osteonecrosis of the femoral head: From nonoperative to operative procedures Open
The incidence of ONFH is increasing, and patients are becoming younger on average. Therefore, the development of hip joint-preserving strategies to treat ONFH at earlier stages is urgently needed, particularly for young patients. However, …
View article: Tenghuang Jiangu tablet in knee osteoarthritis therapy: A prospective multicenter registry study in China
Tenghuang Jiangu tablet in knee osteoarthritis therapy: A prospective multicenter registry study in China Open
THJGT is effective and safe for treating KOA, particularly in improving stiffness symptoms.
View article: Research and design of distributed intelligent electronic pulse barring facility
Research and design of distributed intelligent electronic pulse barring facility Open
Because traditional barring facilities have difficulty in controlling the water surface and have low intelligence degree, a new type of intelligent electronic pulse barring facility was developed. The system established a dynamic charging …
View article: Garnet‐Type Solid‐State Electrolytes: Crystal‐Phase Regulation and Interface Modification for Enhanced Lithium Metal Batteries
Garnet‐Type Solid‐State Electrolytes: Crystal‐Phase Regulation and Interface Modification for Enhanced Lithium Metal Batteries Open
Due to their substantial energy density, rapid charging and discharging rates, and extended lifespan, lithium‐ion batteries have attained broad application across various industries. However, their limited theoretical capacity struggles to…
View article: Identification and Verification of Key Genes Associated with Temozolomide Resistance in Glioblastoma Based on Comprehensive Bioinformatics Analysis.
Identification and Verification of Key Genes Associated with Temozolomide Resistance in Glioblastoma Based on Comprehensive Bioinformatics Analysis. Open
PITX1, TNFRSF11B, and IGFBP2 are key genes associated with the prognosis of GBM patients with TMZ resistance. The differential expression of these genes correlates with adverse outcomes in GBM patients, suggesting that they are valuable bi…
View article: Leapfrogging the Clouds: Singapore Airlines' Innovative Transformation and Voyage to the Future
Leapfrogging the Clouds: Singapore Airlines' Innovative Transformation and Voyage to the Future Open
This paper explores Singapore Airlines (SIA) strategic response to the COVID-19 pandemic, focusing on the airline's recovery strategy, digital transformation, and innovation initiatives. Despite facing significant challenges, SIA demonstra…
View article: Factors influencing the survival status of the hip joint in post-collapse femoral head necrosis
Factors influencing the survival status of the hip joint in post-collapse femoral head necrosis Open
In ONFH, femoral head collapse does not necessarily determine a poor prognosis. Patients with mild collapse (< 3 mm) and preserved anterolateral wall are more likely to retain satisfactory hip function, making them candidates for "survival…
View article: Back Cover Image, Volume 6, Number 7, July 2024
Back Cover Image, Volume 6, Number 7, July 2024 Open
Back cover image: Traditionally, expensive precious metal based electrocatalysts have been relied upon as air electrodes for rechargeable zinc air batteries (ZABs), which have prompted researchers to innovate and develop cost-effective and…
View article: Clinical efficacy of Osteoking in knee osteoarthritis therapy: a prospective, multicenter, non-randomized controlled study in China
Clinical efficacy of Osteoking in knee osteoarthritis therapy: a prospective, multicenter, non-randomized controlled study in China Open
Background Osteoking has been extensively used for the treatment of knee osteoarthritis (KOA). However, it is lack of high-quality evidence on the clinical efficacy of Osteoking against KOA and the comparison with that of nonsteroidal anti…
View article: Ar/NH<sub>3</sub> Plasma Etching of Cobalt‐Nickel Selenide Microspheres Rich in Selenium Vacancies Wrapped with Nitrogen Doped Carbon Nanotubes as Highly Efficient Air Cathode Catalysts for Zinc‐Air Batteries
Ar/NH<sub>3</sub> Plasma Etching of Cobalt‐Nickel Selenide Microspheres Rich in Selenium Vacancies Wrapped with Nitrogen Doped Carbon Nanotubes as Highly Efficient Air Cathode Catalysts for Zinc‐Air Batteries Open
This work utilizes defect engineering, heterostructure, pyridine N‐doping, and carbon supporting to enhance cobalt‐nickel selenide microspheres' performance in the oxygen electrode reaction. Specifically, microspheres mainly composed of Co…
View article: Strong Metal‐Support Interaction Modulation between Pt Nanoclusters and Mn<sub>3</sub>O<sub>4</sub> Nanosheets through Oxygen Vacancy Control to Achieve High Activities for Acidic Hydrogen Evolution
Strong Metal‐Support Interaction Modulation between Pt Nanoclusters and Mn<sub>3</sub>O<sub>4</sub> Nanosheets through Oxygen Vacancy Control to Achieve High Activities for Acidic Hydrogen Evolution Open
The optimization of metal‐support interactions is used to fabricate noble metal‐based nanoclusters with high activity for hydrogen evolution reaction (HER) in acid media. Specifically, the oxygen‐defective Mn 3 O 4 nanosheets supported Pt …
View article: Electrochemical Modeling of Fast Charging in Batteries
Electrochemical Modeling of Fast Charging in Batteries Open
The acceleration of fast charging capabilities has emerged as a pivotal objective within the realms of the battery, electric vehicle, and energy storage sectors. However, the classical electrochemical models are not able to describe voltag…
View article: Co/CoO heterojunction rich in oxygen vacancies introduced by O<sub>2</sub> plasma embedded in mesoporous walls of carbon nanoboxes covered with carbon nanotubes for rechargeable zinc–air battery
Co/CoO heterojunction rich in oxygen vacancies introduced by O<sub>2</sub> plasma embedded in mesoporous walls of carbon nanoboxes covered with carbon nanotubes for rechargeable zinc–air battery Open
Herein, Co/CoO heterojunction nanoparticles (NPs) rich in oxygen vacancies embedded in mesoporous walls of nitrogen‐doped hollow carbon nanoboxes coupled with nitrogen‐doped carbon nanotubes (P–Co/CoO V @NHCNB@NCNT) are well designed throu…
View article: Topical Chinese patent medicines for chronic musculoskeletal pain: systematic review and trial sequential analysis
Topical Chinese patent medicines for chronic musculoskeletal pain: systematic review and trial sequential analysis Open
Purpose Chronic musculoskeletal pain (CMP) is defined as persistent or recurrent pain that occurs in the joints, musculo-soft tissue, spine or bones for more than three months and is not completely curable. Although topical Chinese patent …
View article: Osteoking Promotes Bone Formation and Bone Defect Repair through ZBP1-STAT1-PKR-MLKL-mediated Necroptosis
Osteoking Promotes Bone Formation and Bone Defect Repair through ZBP1-STAT1-PKR-MLKL-mediated Necroptosis Open
Background: Osteoking has been used for fracture therapy with a satisfying clinical efficacy. However, its therapeutic properties and the underlying mechanisms remain elusive. Method: A bone defect rat model was established to evaluate the…
View article: Kinesitherapy for Knee Osteoarthritis Patients Physical and Psychological Health Based on “Traditional Chinese Exercise” Management Modalities: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Kinesitherapy for Knee Osteoarthritis Patients Physical and Psychological Health Based on “Traditional Chinese Exercise” Management Modalities: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials Open
Traditional Chinese exercise (“TCE” management modalities), including but not limited to Tai Chi, Baduanjin, and Yijinjing, has a good effect on improving the physical function of patients with knee osteoarthritis, but less attention has b…
View article: Identification and assessment of novel dynamic biomarkers for monitoring non‐traumatic osteonecrosis of the femoral head staging
Identification and assessment of novel dynamic biomarkers for monitoring non‐traumatic osteonecrosis of the femoral head staging Open
Dear Editor, How to differentially diagnose non-traumatic osteonecrosis of the femoral head (NONFH) patients during the transition from early to late stage accurately and identify the core regulators governing such a critical transition ma…